28S ribosomal protein S28, mitochondrial is a protein that in humans is encoded by the MRPS28gene.[1][2][3]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature.[3]
References
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O'Brien TW, Liu J, Sylvester JE, et al. (2000). "Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 275 (24): 18153–9. doi:10.1074/jbc.M909762199. PMID10751423.
Koc EC, Burkhart W, Blackburn K, et al. (2000). "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins". J. Biol. Chem. 275 (42): 32585–91. doi:10.1074/jbc.M003596200. PMID10938081.
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID11543634.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID12706105.
