MRAS

Muscle RAS oncogene homolog
File:PBB Protein MRAS image.jpg PDB rendering based on 1x1r.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x1r​, 1x1s​
Identifiers
Symbols	MRAS ; FLJ42964; M-RAs; R-RAS3; RRAS3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7424
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MRAS 206538 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Muscle RAS oncogene homolog, also known as MRAS, is a human gene.

Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]

Further reading

• Matsumoto K, Asano T, Endo T (1997). "Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton". Oncogene. 15 (20): 2409–17. doi:10.1038/sj.onc.1201416. PMID 9395237.CS1 maint: Multiple names: authors list (link)
• Kimmelman A, Tolkacheva T, Lorenzi MV; et al. (1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Quilliam LA, Castro AF, Rogers-Graham KS; et al. (1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". J. Biol. Chem. 274 (34): 23850–7. PMID 10446149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Louahed J, Grasso L, De Smet C; et al. (1999). "Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones". Blood. 94 (5): 1701–10. PMID 10477695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ehrhardt GR, Leslie KB, Lee F; et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. PMID 10498616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimmelman AC, Osada M, Chan AM (2000). "R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells". Oncogene. 19 (16): 2014–22. doi:10.1038/sj.onc.1203530. PMID 10803462.CS1 maint: Multiple names: authors list (link)
• Rebhun JF, Castro AF, Quilliam LA (2001). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.CS1 maint: Multiple names: authors list (link)
• Gao X, Satoh T, Liao Y; et al. (2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J. Biol. Chem. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M; et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimmelman AC, Nuñez Rodriguez N, Chan AM (2002). "R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade". Mol. Cell. Biol. 22 (16): 5946–61. PMID 12138204.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitin NY, Ramocki MB, Zullo AJ; et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roberts AE, Araki T, Swanson KD; et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshikawa Y, Satoh T, Tamura T; et al. (2007). "The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes". Mol. Biol. Cell. 18 (8): 2949–59. doi:10.1091/mbc.E07-03-0250. PMID 17538012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)