MPP5: Difference between revisions

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{{Infobox_gene}}
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'''MAGUK p55 subfamily member 5''' is a [[protein]] that in humans is encoded by the ''MPP5'' [[gene]].<ref name="pmid11927608">{{cite journal |vauthors=Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B | title = The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost | journal = J Cell Biol | volume = 157 | issue = 1 | pages = 161–72 |date=Apr 2002 | pmid = 11927608 | pmc = 2173254 | doi = 10.1083/jcb.200109010 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64398| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MPP5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1va8.
| PDB = {{PDB2|1va8}}, {{PDB2|1y76}}
| Name = Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
| HGNCid = 18669
| Symbol = MPP5
| AltSymbols =; FLJ12615; PALS1
| OMIM = 606958
| ECnumber =
| Homologene = 9512
| MGIid = 1927339
| GeneAtlas_image1 = PBB_GE_MPP5_219321_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64398
    | Hs_Ensembl = ENSG00000072415
    | Hs_RefseqProtein = NP_071919
    | Hs_RefseqmRNA = NM_022474
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 66777774
    | Hs_GenLoc_end = 66872288
    | Hs_Uniprot = Q8N3R9
    | Mm_EntrezGene = 56217
    | Mm_Ensembl = ENSMUSG00000021112
    | Mm_RefseqmRNA = NM_019579
    | Mm_RefseqProtein = NP_062525
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 79667764
    | Mm_GenLoc_end = 79759426
    | Mm_Uniprot = Q9JLB2
  }}
}}
'''Membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)''', also known as '''MPP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64398| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64398| accessdate = }}</ref>
| summary_text = Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64398| accessdate = }}</ref>
}}
}}
==Interactions==
MPP5 has been shown to [[Protein-protein interaction|interact]] with [[INADL]] and [[FAM71D]].<ref name=pmid11927608 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal | author=Kamberov E, Makarova O, Roh M, ''et al.'' |title=Molecular cloning and characterization of Pals, proteins associated with mLin-7. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11425-31 |year= 2000 |pmid= 10753959 |doi=  }}
*{{cite journal   |vauthors=Kamberov E, Makarova O, Roh M, etal |title=Molecular cloning and characterization of Pals, proteins associated with mLin-7. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11425–31 |year= 2000 |pmid= 10753959 |doi=10.1074/jbc.275.15.11425 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Tseng TC, Marfatia SM, Bryant PJ, ''et al.'' |title=VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 3 |pages= 249-59 |year= 2001 |pmid= 11311936 |doi=  }}
*{{cite journal   |vauthors=Tseng TC, Marfatia SM, Bryant PJ, etal |title=VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. |journal=Biochim. Biophys. Acta |volume=1518 |issue= 3 |pages= 249–59 |year= 2001 |pmid= 11311936 |doi=  10.1016/s0167-4781(01)00191-9}}
*{{cite journal | author=Roh MH, Makarova O, Liu CJ, ''et al.'' |title=The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 161-72 |year= 2002 |pmid= 11927608 |doi= 10.1083/jcb.200109010 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Makarova O, Roh MH, Liu CJ, etal |title=Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). |journal=Gene |volume=302 |issue= 1–2 |pages= 21–9 |year= 2003 |pmid= 12527193 |doi=10.1016/S0378111902010843  }}
*{{cite journal | author=Makarova O, Roh MH, Liu CJ, ''et al.'' |title=Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1). |journal=Gene |volume=302 |issue= 1-2 |pages= 21-9 |year= 2003 |pmid= 12527193 |doi= }}
*{{cite journal   |vauthors=Hurd TW, Gao L, Roh MH, etal |title=Direct interaction of two polarity complexes implicated in epithelial tight junction assembly |journal=Nat. Cell Biol. |volume=5 |issue= 2 |pages= 137–42 |year= 2003 |pmid= 12545177 |doi= 10.1038/ncb923 }}
*{{cite journal  | author=Hurd TW, Gao L, Roh MH, ''et al.'' |title=Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. |journal=Nat. Cell Biol. |volume=5 |issue= 2 |pages= 137-42 |year= 2003 |pmid= 12545177 |doi= 10.1038/ncb923 }}
*{{cite journal  |vauthors=Roh MH, Fan S, Liu CJ, Margolis B |title=The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells |journal=J. Cell Sci. |volume=116 |issue= Pt 14 |pages= 2895–906 |year= 2004 |pmid= 12771187 |doi= 10.1242/jcs.00500 }}
*{{cite journal | author=Roh MH, Fan S, Liu CJ, Margolis B |title=The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. |journal=J. Cell. Sci. |volume=116 |issue= Pt 14 |pages= 2895-906 |year= 2004 |pmid= 12771187 |doi= 10.1242/jcs.00500 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Penkert RR, DiVittorio HM, Prehoda KE |title=Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1122–7 |year= 2004 |pmid= 15475968 |doi= 10.1038/nsmb839  | pmc=2140275 }}
*{{cite journal | author=Penkert RR, DiVittorio HM, Prehoda KE |title=Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1122-7 |year= 2004 |pmid= 15475968 |doi= 10.1038/nsmb839 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Stöhr H, Molday LL, Molday RS, etal |title=Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina |journal=J. Comp. Neurol. |volume=481 |issue= 1 |pages= 31–41 |year= 2005 |pmid= 15558731 |doi= 10.1002/cne.20367 }}
*{{cite journal  | author=Stöhr H, Molday LL, Molday RS, ''et al.'' |title=Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina. |journal=J. Comp. Neurol. |volume=481 |issue= 1 |pages= 31-41 |year= 2005 |pmid= 15558731 |doi= 10.1002/cne.20367 }}
*{{cite journal  |vauthors=Feng W, Long JF, Zhang M |title=A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 19 |pages= 6861–6 |year= 2005 |pmid= 15863617 |doi= 10.1073/pnas.0409346102  | pmc=1100767 }}
*{{cite journal | author=Feng W, Long JF, Zhang M |title=A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 19 |pages= 6861-6 |year= 2005 |pmid= 15863617 |doi= 10.1073/pnas.0409346102 }}
*{{cite journal   |vauthors=Kantardzhieva A, Gosens I, Alexeeva S, etal |title=MPP5 recruits MPP4 to the CRB1 complex in photoreceptors |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 6 |pages= 2192–201 |year= 2005 |pmid= 15914641 |doi= 10.1167/iovs.04-1417 }}
*{{cite journal | author=Kantardzhieva A, Gosens I, Alexeeva S, ''et al.'' |title=MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 6 |pages= 2192-201 |year= 2005 |pmid= 15914641 |doi= 10.1167/iovs.04-1417 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=64398}}
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Latest revision as of 20:20, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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Wikidata
View/Edit Human

MAGUK p55 subfamily member 5 is a protein that in humans is encoded by the MPP5 gene.[1][2]

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM][2]

Interactions

MPP5 has been shown to interact with INADL and FAM71D.[1]

References

  1. ↑ 1.0 1.1 Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
  2. ↑ 2.0 2.1 "Entrez Gene: MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)".

Further reading



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