MNT (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''MNT''' (Max's Next Tango) is a Max-binding [[protein]] that is encoded by the ''MNT'' [[gene]] <ref name="ReferenceA">{{cite journal|last1=Hurlin|first1=Peter|last2=Queva|first2=Christoph|last3=Eisenman|first3=Robert|title=Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites|journal=Genes & Development|date=January 1, 1997|volume=11|issue=1|pages=44–58|pmid=9000049|doi=10.1101/gad.11.1.44}}</ref><ref name="pmid9598315">{{cite journal | vauthors = Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R | title = The human ROX gene: genomic structure and mutation analysis in human breast tumors | journal = Genomics | volume = 49 | issue = 2 | pages = 275–82 | date = Apr 1998 | pmid = 9598315 | pmc = | doi = 10.1006/geno.1998.5241 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MNT MAX binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAX binding protein
| HGNCid = 7188
| Symbol = MNT
| AltSymbols =; MAD6; MXD6; ROX
| OMIM = 603039
| ECnumber = 
| Homologene = 7842
| MGIid = 109150
| GeneAtlas_image1 = PBB_GE_MNT_204206_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007569 |text = cell aging}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4335
    | Hs_Ensembl = ENSG00000070444
    | Hs_RefseqProtein = NP_064706
    | Hs_RefseqmRNA = NM_020310
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 2234104
    | Hs_GenLoc_end = 2251162
    | Hs_Uniprot = Q99583
    | Mm_EntrezGene = 17428
    | Mm_Ensembl = ENSMUSG00000000282
    | Mm_RefseqmRNA = NM_010813
    | Mm_RefseqProtein = NP_034943
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74647119
    | Mm_GenLoc_end = 74661905
    | Mm_Uniprot = Q3UGG9
  }}
}}
'''MAX binding protein''', also known as '''MNT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MNT MAX binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[Myc]]/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain <ref name="ReferenceA"/><ref>{{cite journal|last1=Merroni|first1=G|last2=Reymond|first2=A|last3=Alcalay|first3=M|last4=Borsani|first4=G|last5=Tanigami|first5=A|last6=Tonlorenzi|first6=R|last7=Lo Nigro|first7=C|last8=Messali|first8=S|last9=Zollo|first9=M|last10=Ledbetter|first10=DH|last11=Brent|first11=R|last12=Ballabio|first12=A|last13=Carrozzo|first13=R|title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.|journal=EMBO J|date=May 15, 1997|volume=16|issue=10|pages=2892–2906|doi=10.1093/emboj/16.10.2892|pmc=1169897|pmid=9184233}}</ref>
{{PBB_Summary
| section_title =
| summary_text = The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.<ref name="entrez">{{cite web | title = Entrez Gene: MNT MAX binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MNT (gene) has been shown to [[Protein-protein interaction|interact]] with [[MLX (gene)|MLX]],<ref name=pmid11230181>{{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = Mar 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = Jul 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}</ref> [[SIN3A]]<ref name=pmid9184233>{{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | journal = The EMBO Journal | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | PMID=9184233 | doi = 10.1093/emboj/16.10.2892 | pmc=1169897}}</ref> and [[MAX (gene)|MAX]].<ref name=pmid9184233/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | journal = The EMBO Journal | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | pmid = 9184233 | pmc = 1169897 | doi = 10.1093/emboj/16.10.2892 }}
| citations =
* {{cite journal | vauthors = Hirotsune S, Pack SD, Chong SS, Robbins CM, Pavan WJ, Ledbetter DH, Wynshaw-Boris A | title = Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region | journal = Genome Research | volume = 7 | issue = 6 | pages = 625–34 | date = Jun 1997 | pmid = 9199935 | pmc = 310661 | doi = 10.1101/gr.7.6.625 }}
*{{cite journal | author=Meroni G, Reymond A, Alcalay M, ''et al.'' |title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2892-906 |year= 1997 |pmid= 9184233 |doi= 10.1093/emboj/16.10.2892 }}
* {{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = Jul 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}
*{{cite journal | author=Hirotsune S, Pack SD, Chong SS, ''et al.'' |title=Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region. |journal=Genome Res. |volume=7 |issue= 6 |pages= 625-34 |year= 1997 |pmid= 9199935 |doi=  }}
* {{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = Mar 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}
*{{cite journal  | author=Nigro CL, Venesio T, Reymond A, ''et al.'' |title=The human ROX gene: genomic structure and mutation analysis in human breast tumors. |journal=Genomics |volume=49 |issue= 2 |pages= 275-82 |year= 1998 |pmid= 9598315 |doi= 10.1006/geno.1998.5241 }}
* {{cite journal | vauthors = Stoneley M, Spencer JP, Wright SC | title = An internal ribosome entry segment in the 5' untranslated region of the mnt gene | journal = Oncogene | volume = 20 | issue = 7 | pages = 893–7 | date = Feb 2001 | pmid = 11314024 | doi = 10.1038/sj.onc.1204157 }}
*{{cite journal | author=Meroni G, Cairo S, Merla G, ''et al.'' |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266-77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634 }}
* {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7021–8 | date = Mar 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 }}
*{{cite journal | author=Cairo S, Merla G, Urbinati F, ''et al.'' |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617-27 |year= 2001 |pmid= 11230181 |doi= }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Stoneley M, Spencer JP, Wright SC |title=An internal ribosome entry segment in the 5' untranslated region of the mnt gene. |journal=Oncogene |volume=20 |issue= 7 |pages= 893-7 |year= 2001 |pmid= 11314024 |doi= 10.1038/sj.onc.1204157 }}
* {{cite journal | vauthors = Smith AG, Popov N, Imreh M, Axelson H, Henriksson M | title = Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells | journal = Journal of Cellular Biochemistry | volume = 92 | issue = 6 | pages = 1282–95 | date = Aug 2004 | pmid = 15258910 | doi = 10.1002/jcb.20121 }}
*{{cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mammalian Genome | volume = 16 | issue = 12 | pages = 942–54 | date = Dec 2005 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Guo XL, Pan L, Zhang XJ, Suo XH, Niu ZY, Zhang JY, Wang F, Dong ZR, Da W, Ohno R | title = Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia | journal = Leukemia & Lymphoma | volume = 48 | issue = 6 | pages = 1200–7 | date = Jun 2007 | pmid = 17577784 | doi = 10.1080/10428190701342018 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Smith AG, Popov N, Imreh M, ''et al.'' |title=Expression and DNA-binding activity of MYCN/Max and Mnt/Max during induced differentiation of human neuroblastoma cells. |journal=J. Cell. Biochem. |volume=92 |issue= 6 |pages= 1282-95 |year= 2005 |pmid= 15258910 |doi= 10.1002/jcb.20121 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
*{{cite journal | author=Guo XL, Pan L, Zhang XJ, ''et al.'' |title=Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. |journal=Leuk. Lymphoma |volume=48 |issue= 6 |pages= 1200-7 |year= 2007 |pmid= 17577784 |doi= 10.1080/10428190701342018 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MNT+protein,+human}}
* {{MeshName|MNT+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-17-stub}}

Latest revision as of 18:21, 8 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MNT (Max's Next Tango) is a Max-binding protein that is encoded by the MNT gene [1][2][3]

Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain [1][4]

Interactions

MNT (gene) has been shown to interact with MLX,[5][6] SIN3A[7] and MAX.[7]

References

  1. ↑ 1.0 1.1 Hurlin, Peter; Queva, Christoph; Eisenman, Robert (January 1, 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development. 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.
  2. ↑ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (Apr 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–82. doi:10.1006/geno.1998.5241. PMID 9598315.
  3. ↑ "Entrez Gene: MNT MAX binding protein".
  4. ↑ Merroni, G; Reymond, A; Alcalay, M; Borsani, G; Tanigami, A; Tonlorenzi, R; Lo Nigro, C; Messali, S; Zollo, M; Ledbetter, DH; Brent, R; Ballabio, A; Carrozzo, R (May 15, 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
  5. ↑ Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (Mar 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
  6. ↑ Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (Jul 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.
  7. ↑ 7.0 7.1 Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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