MNT (gene): Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
MNT (Max's Next Tango) is a Max-binding [[protein]] that is encoded by the ''MNT'' [[gene]] <ref>{{cite journal|last1=Hurlin|first1=Peter|last2=Queva|first2=Christoph|last3=Eisenman|first3=Robert|title=Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites|journal=Genes & Development|date=January 1, 1997|volume=11|issue=1|page=44-58|pmid=9000049}}</ref><ref name="pmid9598315">{{cite journal | vauthors = Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R | title = The human ROX gene: genomic structure and mutation analysis in human breast tumors | journal = Genomics | volume = 49 | issue = 2 | pages = 275–82 | date = Apr 1998 | pmid = 9598315 | pmc =  | doi = 10.1006/geno.1998.5241 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MNT MAX binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335| accessdate = }}</ref>
'''MNT''' (Max's Next Tango) is a Max-binding [[protein]] that is encoded by the ''MNT'' [[gene]] <ref name="ReferenceA">{{cite journal|last1=Hurlin|first1=Peter|last2=Queva|first2=Christoph|last3=Eisenman|first3=Robert|title=Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites|journal=Genes & Development|date=January 1, 1997|volume=11|issue=1|pages=44–58|pmid=9000049|doi=10.1101/gad.11.1.44}}</ref><ref name="pmid9598315">{{cite journal | vauthors = Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R | title = The human ROX gene: genomic structure and mutation analysis in human breast tumors | journal = Genomics | volume = 49 | issue = 2 | pages = 275–82 | date = Apr 1998 | pmid = 9598315 | pmc =  | doi = 10.1006/geno.1998.5241 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MNT MAX binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4335| accessdate = }}</ref>


== Function ==
== Function ==


The [[Myc]]/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain <ref>{{cite journal|last1=Hurlin|first1=Peter|last2=Queva|first2=Christoph|last3=Eisenman|first3=Robert|title=Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites|journal=Genes & Development|date=January 1, 1997|volume=11|issue=1|page=44-58|pmid=9000049}}</ref><ref>{{cite journal|last1=Merroni|first1=G|last2=Reymond|first2=A|last3=Alcalay|first3=M|last4=Borsani|first4=G|last5=Tanigami|first5=A|last6=Tonlorenzi|first6=R|last7=Lo Nigro|first7=C|last8=Messali|first8=S|last9=Zollo|first9=M|last10=Ledbetter|first10=DH|last11=Brent|first11=R|last12=Ballabio|first12=A|last13=Carrozzo|first13=R|title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.|journal=EMBO J|date=May 15, 1997|volume=16|issue=10|pages=2892-2906|doi=10.1093/emboj/16.10.2892|pmc=1169897}}</ref>
The [[Myc]]/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain <ref name="ReferenceA"/><ref>{{cite journal|last1=Merroni|first1=G|last2=Reymond|first2=A|last3=Alcalay|first3=M|last4=Borsani|first4=G|last5=Tanigami|first5=A|last6=Tonlorenzi|first6=R|last7=Lo Nigro|first7=C|last8=Messali|first8=S|last9=Zollo|first9=M|last10=Ledbetter|first10=DH|last11=Brent|first11=R|last12=Ballabio|first12=A|last13=Carrozzo|first13=R|title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.|journal=EMBO J|date=May 15, 1997|volume=16|issue=10|pages=2892–2906|doi=10.1093/emboj/16.10.2892|pmc=1169897|pmid=9184233}}</ref>


== Interactions ==
== Interactions ==


MNT (gene) has been shown to [[Protein-protein interaction|interact]] with [[MLX (gene)|MLX]],<ref name=pmid11230181>{{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = Mar 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = Jul 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}</ref> [[SIN3A]]<ref name=pmid9184233>{{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | journal = The EMBO Journal | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | PMID=9184233 | doi = 10.1093/emboj/16.10.2892 }}</ref> and [[MAX (gene)|MAX]].<ref name=pmid9184233/>
MNT (gene) has been shown to [[Protein-protein interaction|interact]] with [[MLX (gene)|MLX]],<ref name=pmid11230181>{{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = Mar 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = Jul 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}</ref> [[SIN3A]]<ref name=pmid9184233>{{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor | journal = The EMBO Journal | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | PMID=9184233 | doi = 10.1093/emboj/16.10.2892 | pmc=1169897}}</ref> and [[MAX (gene)|MAX]].<ref name=pmid9184233/>


== References ==
== References ==

Latest revision as of 18:21, 8 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

MNT (Max's Next Tango) is a Max-binding protein that is encoded by the MNT gene [1][2][3]

Function

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA and recruiting Sin3 corepressor proteins through its N-terminal Sin3-interaction domain [1][4]

Interactions

MNT (gene) has been shown to interact with MLX,[5][6] SIN3A[7] and MAX.[7]

References

  1. ↑ 1.0 1.1 Hurlin, Peter; Queva, Christoph; Eisenman, Robert (January 1, 1997). "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites". Genes & Development. 11 (1): 44–58. doi:10.1101/gad.11.1.44. PMID 9000049.
  2. ↑ Lo Nigro C, Venesio T, Reymond A, Meroni G, Alberici P, Cainarca S, Enrico F, Stack M, Ledbetter DH, Liscia DS, Ballabio A, Carrozzo R (Apr 1998). "The human ROX gene: genomic structure and mutation analysis in human breast tumors". Genomics. 49 (2): 275–82. doi:10.1006/geno.1998.5241. PMID 9598315.
  3. ↑ "Entrez Gene: MNT MAX binding protein".
  4. ↑ Merroni, G; Reymond, A; Alcalay, M; Borsani, G; Tanigami, A; Tonlorenzi, R; Lo Nigro, C; Messali, S; Zollo, M; Ledbetter, DH; Brent, R; Ballabio, A; Carrozzo, R (May 15, 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–2906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
  5. ↑ Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (Mar 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
  6. ↑ Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (Jul 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.
  7. ↑ 7.0 7.1 Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". The EMBO Journal. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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