MLX (gene): Difference between revisions
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'''Max-like protein X''' is a [[protein]] that in humans is encoded by the ''MLX'' [[gene]].<ref name="pmid8973301">{{cite journal |vauthors=Bjerknes M, Cheng H | title = TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor | journal = Gene | volume = 181 | issue = 1–2 | pages = 7–11 |date=January 1997 | pmid = 8973301 | pmc = | doi =10.1016/S0378-1119(96)00376-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref> | |||
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| summary_text = The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form | | summary_text = The product of this gene belongs to the family of [[basic helix-loop-helix]] [[leucine zipper]] (bHLH-Zip) [[transcription factors]]. These factors form [[heterodimer]]s with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely [[Mad1]] and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" /> | ||
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==Interactions== | |||
MLX (gene) has been shown to [[Protein-protein interaction|interact]] with [[MNT (gene)|MNT]],<ref name=pmid11230181>{{cite journal |last=Cairo |first=S |authorlink= |author2=Merla G |author3=Urbinati F |author4=Ballabio A |author5=Reymond A |date=March 2001 |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue=6 |pages=617–27 |publisher= |location = England| issn = 0964-6906| pmid = 11230181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal |last=Meroni |first=G |authorlink= |author2=Cairo S |author3=Merla G |author4=Messali S |author5=Brent R |author6=Ballabio A |author7=Reymond A |date=July 2000 |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue=29 |pages=3266–77 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10918583 |doi = 10.1038/sj.onc.1203634 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MXD1]]<ref name=pmid11230181/><ref name=pmid10918583/> and [[MLXIPL]].<ref name=pmid11230181/> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Rommens JM | * {{cite journal | author=Rommens JM |title=Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21 |journal=Genomics |volume=28 |issue= 3 |pages= 530–42 |year= 1996 |pmid= 7490091 |doi=10.1006/geno.1995.1185 |name-list-format=vanc| author2=Durocher F | author3=McArthur J | display-authors=3 | last4=Tonin | first4=Patricia | last5=Leblanc | first5=Jean-François | last6=Allen | first6=Todd | last7=Samson | first7=Carolle | last8=Ferri | first8=Lorenzo | last9=Narod | first9=Steven }} | ||
*{{cite journal | | * {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | author=Hillier LD | * {{cite journal | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |name-list-format=vanc| author2=Lennon G | author3=Becker M | display-authors=3 | last4=Bonaldo | first4=M F | last5=Chiapelli | first5=B | last6=Chissoe | first6=S | last7=Dietrich | first7=N | last8=Dubuque | first8=T | last9=Favello | first9=A }} | ||
* {{cite journal |vauthors=Billin AN, Eilers AL, Queva C, Ayer DE |title=Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36344–50 |year= 2000 |pmid= 10593926 |doi=10.1074/jbc.274.51.36344 }} | |||
*{{cite journal | | * {{cite journal | author=Meroni G |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266–77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634 |name-list-format=vanc| author2=Cairo S | author3=Merla G | display-authors=3 | last4=Messali | first4=Silvia | last5=Brent | first5=Roger | last6=Ballabio | first6=Andrea | last7=Reymond | first7=Alexandre }} | ||
*{{cite journal | author=Meroni G | * {{cite journal | author=Billin AN |title=MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8845–54 |year= 2000 |pmid= 11073985 |doi=10.1128/MCB.20.23.8845-8854.2000 | pmc=86535 |name-list-format=vanc| author2=Eilers AL | author3=Coulter KL | display-authors=3 | last4=Logan | first4=J. S. | last5=Ayer | first5=D. E. }} | ||
*{{cite journal | author=Billin AN | * {{cite journal | author=Cairo S |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617–27 |year= 2001 |pmid= 11230181 |doi=10.1093/hmg/10.6.617 |name-list-format=vanc| author2=Merla G | author3=Urbinati F | display-authors=3 | last4=Ballabio | first4=A | last5=Reymond | first5=A }} | ||
*{{cite journal | author=Cairo S | * {{cite journal | author=Eilers AL |title=A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8514–26 |year= 2003 |pmid= 12446771 |doi=10.1128/MCB.22.24.8514-8526.2002 | pmc=139889 |name-list-format=vanc| author2=Sundwall E | author3=Lin M | display-authors=3 | last4=Sullivan | first4=A. A. | last5=Ayer | first5=D. E. }} | ||
*{{cite journal | author=Eilers AL | * {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Strausberg RL | * {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Ota T | * {{cite journal |vauthors=Merla G, Howald C, Antonarakis SE, Reymond A |title=The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3 |journal=Hum. Mol. Genet. |volume=13 |issue= 14 |pages= 1505–14 |year= 2005 |pmid= 15163635 |doi= 10.1093/hmg/ddh163 }} | ||
*{{cite journal | | * {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Gerhard DS | * {{cite journal |vauthors=Ma L, Tsatsos NG, Towle HC |title=Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 12019–27 |year= 2005 |pmid= 15664996 |doi= 10.1074/jbc.M413063200 }} | ||
*{{cite journal | | * {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
*{{cite journal | author=Rual JF | * {{cite journal | author=Sans CL |title=MondoA-Mlx Heterodimers Are Candidate Sensors of Cellular Energy Status: Mitochondrial Localization and Direct Regulation of Glycolysis |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4863–71 |year= 2006 |pmid= 16782875 |doi= 10.1128/MCB.00657-05 | pmc=1489152 |name-list-format=vanc| author2=Satterwhite DJ | author3=Stoltzman CA | display-authors=3 | last4=Breen | first4=K. T. | last5=Ayer | first5=D. E. }} | ||
*{{cite journal | author=Sans CL | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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* {{MeshName|MLX+protein,+human}} | * {{MeshName|MLX+protein,+human}} | ||
{{NLM content}} | |||
{{Transcription factors|g1}} | |||
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[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
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Revision as of 06:39, 4 September 2017
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Entrez |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
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Wikidata | |||||||
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Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]
Interactions
MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]
References
- ↑ Bjerknes M, Cheng H (January 1997). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
- ↑ 2.0 2.1 "Entrez Gene: MLX MAX-like protein X".
- ↑ 3.0 3.1 3.2 Cairo, S; Merla G; Urbinati F; Ballabio A; Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. England. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. ISSN 0964-6906. PMID 11230181.
- ↑ 4.0 4.1 Meroni, G; Cairo S; Merla G; Messali S; Brent R; Ballabio A; Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. ENGLAND. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. ISSN 0950-9232. PMID 10918583.
Further reading
- Rommens JM, Durocher F, McArthur J, et al. (1996). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Billin AN, Eilers AL, Queva C, Ayer DE (2000). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.
- Meroni G, Cairo S, Merla G, et al. (2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.
- Billin AN, Eilers AL, Coulter KL, et al. (2000). "MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network". Mol. Cell. Biol. 20 (23): 8845–54. doi:10.1128/MCB.20.23.8845-8854.2000. PMC 86535. PMID 11073985.
- Cairo S, Merla G, Urbinati F, et al. (2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Hum. Mol. Genet. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
- Eilers AL, Sundwall E, Lin M, et al. (2003). "A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex". Mol. Cell. Biol. 22 (24): 8514–26. doi:10.1128/MCB.22.24.8514-8526.2002. PMC 139889. PMID 12446771.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Merla G, Howald C, Antonarakis SE, Reymond A (2005). "The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3". Hum. Mol. Genet. 13 (14): 1505–14. doi:10.1093/hmg/ddh163. PMID 15163635.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ma L, Tsatsos NG, Towle HC (2005). "Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes". J. Biol. Chem. 280 (12): 12019–27. doi:10.1074/jbc.M413063200. PMID 15664996.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sans CL, Satterwhite DJ, Stoltzman CA, et al. (2006). "MondoA-Mlx Heterodimers Are Candidate Sensors of Cellular Energy Status: Mitochondrial Localization and Direct Regulation of Glycolysis". Mol. Cell. Biol. 26 (13): 4863–71. doi:10.1128/MCB.00657-05. PMC 1489152. PMID 16782875.
External links
- MLX+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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