MLLT10: Difference between revisions

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Identifiers
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Latest revision as of 06:38, 4 September 2017

Protein AF-10 is a protein that in humans is encoded by the MLLT10 gene.^[1]^[2]

Interactions

MLLT10 has been shown to interact with SS18.^[3]

References

↑ Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. PMID 7888665.
↑ "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".
↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP (1998). "Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides". Leukemia. 12 (9): 1404–10. doi:10.1038/sj.leu.2401109. PMID 9737689.
Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V (2000). "Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation". J. Mol. Biol. 299 (2): 369–78. doi:10.1006/jmbi.2000.3766. PMID 10860745.
Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V (2000). "Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia". Br. J. Haematol. 110 (3): 547–51. doi:10.1046/j.1365-2141.2000.02212.x. PMID 10997963.
de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.
Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD (2002). "The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex". Blood. 99 (1): 275–81. doi:10.1182/blood.V99.1.275. PMID 11756182.
Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS (2002). "Characterization and potential function of a novel testis-specific nucleoporin BS-63". Mol. Reprod. Dev. 61 (1): 126–34. doi:10.1002/mrd.1139. PMID 11774384.
Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM (2002). "Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia". Cancer Genet. Cytogenet. 135 (2): 187–91. doi:10.1016/S0165-4608(01)00644-6. PMID 12127405.
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E (2002). "ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation". Mol. Cell. 10 (5): 1119–28. doi:10.1016/S1097-2765(02)00740-2. PMID 12453419.
Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM (2003). "The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions". Mol. Cell. Biol. 23 (1): 119–30. doi:10.1128/MCB.23.1.119-130.2003. PMC 140655. PMID 12482966.
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y (2005). "hDOT1L links histone methylation to leukemogenesis". Cell. 121 (2): 167–78. doi:10.1016/j.cell.2005.02.020. PMID 15851025.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[pmid7888665-1] Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD (Apr 1995). "A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia". Blood. 85 (6): 1435–41. PMID 7888665.

[entrez-2] "Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10".

[pmid11423977-3] Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Protein AF-10''' is a [[protein]] that in humans is encoded by the ''MLLT10'' [[gene]].<ref name="pmid7888665">{{cite journal | vauthors = Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD | title = A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia | journal = Blood | volume = 85 | issue = 6 | pages = 1435–41  | date = Apr 1995 | pmid = 7888665 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8028| accessdate = }}</ref>
-| update_page = yes
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-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
- | HGNCid = 16063
- | Symbol = MLLT10
- | AltSymbols =; AF10; DKFZp686E10210; MGC75086
- | OMIM = 602409
- | ECnumber =
- | Homologene = 20973
- | MGIid = 1329038
- | GeneAtlas_image1 = PBB_GE_MLLT10_216503_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8028
-    | Hs_Ensembl = ENSG00000078403
-    | Hs_RefseqProtein = NP_001009569
-    | Hs_RefseqmRNA = NM_001009569
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 21863100
-    | Hs_GenLoc_end = 22072565
-    | Hs_Uniprot = P55197
-    | Mm_EntrezGene = 17354
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA = NM_010804
-    | Mm_RefseqProtein = NP_034934
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10''', also known as '''MLLT10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8028| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+MLLT10 has been shown to [[Protein-protein interaction|interact]] with [[SS18]].<ref name=pmid11423977>{{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9  | date = May 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Silliman CC, McGavran L, Wei Q, Miller LA, Li S, Hunger SP | title = Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides | journal = Leukemia | volume = 12 | issue = 9 | pages = 1404–10 | year = 1998 | pmid = 9737689 | doi = 10.1038/sj.leu.2401109 }}
-| citations =
+* {{cite journal | vauthors = Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V | title = Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation | journal = J. Mol. Biol. | volume = 299 | issue = 2 | pages = 369–78 | year = 2000 | pmid = 10860745 | doi = 10.1006/jmbi.2000.3766 }}
-*{{cite journal  | author=Chaplin T, Ayton P, Bernard OA, ''et al.'' |title=A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. |journal=Blood |volume=85 |issue= 6 |pages= 1435-41 |year= 1995 |pmid= 7888665 |doi=  }}
+* {{cite journal | vauthors = Lillington DM, Jaju RJ, Shankar AG, Neat M, Kearney L, Young BD, Saha V | title = Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia | journal = Br. J. Haematol. | volume = 110 | issue = 3 | pages = 547–51 | year = 2000 | pmid = 10997963 | doi = 10.1046/j.1365-2141.2000.02212.x }}
-*{{cite journal  | author=Silliman CC, McGavran L, Wei Q, ''et al.'' |title=Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides. |journal=Leukemia |volume=12 |issue= 9 |pages= 1404-10 |year= 1998 |pmid= 9737689 |doi=  }}
+* {{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9 | year = 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}
-*{{cite journal  | author=Linder B, Newman R, Jones LK, ''et al.'' |title=Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. |journal=J. Mol. Biol. |volume=299 |issue= 2 |pages= 369-78 |year= 2000 |pmid= 10860745 |doi= 10.1006/jmbi.2000.3766 }}
+* {{cite journal | vauthors = Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD | title = The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex | journal = Blood | volume = 99 | issue = 1 | pages = 275–81 | year = 2002 | pmid = 11756182 | doi = 10.1182/blood.V99.1.275 }}
-*{{cite journal  | author=Lillington DM, Jaju RJ, Shankar AG, ''et al.'' |title=Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia. |journal=Br. J. Haematol. |volume=110 |issue= 3 |pages= 547-51 |year= 2000 |pmid= 10997963 |doi=  }}
+* {{cite journal | vauthors = Cai Y, Gao Y, Sheng Q, Miao S, Cui X, Wang L, Zong S, Koide SS | title = Characterization and potential function of a novel testis-specific nucleoporin BS-63 | journal = Mol. Reprod. Dev. | volume = 61 | issue = 1 | pages = 126–34 | year = 2002 | pmid = 11774384 | doi = 10.1002/mrd.1139 }}
-*{{cite journal  | author=de Bruijn DR, dos Santos NR, Thijssen J, ''et al.'' |title=The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. |journal=Oncogene |volume=20 |issue= 25 |pages= 3281-9 |year= 2001 |pmid= 11423977 |doi= 10.1038/sj.onc.1204419 }}
+* {{cite journal | vauthors = Roll P, Zattara-Cannoni H, Bustos-Bernard MC, Curtillet C, Michel G, Vagner-Capodano AM | title = Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia | journal = Cancer Genet. Cytogenet. | volume = 135 | issue = 2 | pages = 187–91 | year = 2002 | pmid = 12127405 | doi = 10.1016/S0165-4608(01)00644-6 }}
-*{{cite journal  | author=Debernardi S, Bassini A, Jones LK, ''et al.'' |title=The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. |journal=Blood |volume=99 |issue= 1 |pages= 275-81 |year= 2002 |pmid= 11756182 |doi=  }}
+* {{cite journal | vauthors = Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E | title = ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation | journal = Mol. Cell | volume = 10 | issue = 5 | pages = 1119–28 | year = 2002 | pmid = 12453419 | doi = 10.1016/S1097-2765(02)00740-2 }}
-*{{cite journal  | author=Cai Y, Gao Y, Sheng Q, ''et al.'' |title=Characterization and potential function of a novel testis-specific nucleoporin BS-63. |journal=Mol. Reprod. Dev. |volume=61 |issue= 1 |pages= 126-34 |year= 2002 |pmid= 11774384 |doi= 10.1002/mrd.1139 }}
+* {{cite journal | vauthors = Perrin L, Bloyer S, Ferraz C, Agrawal N, Sinha P, Dura JM | title = The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions | journal = Mol. Cell. Biol. | volume = 23 | issue = 1 | pages = 119–30 | year = 2003 | pmid = 12482966 | pmc = 140655 | doi = 10.1128/MCB.23.1.119-130.2003 }}
-*{{cite journal  | author=Roll P, Zattara-Cannoni H, Bustos-Bernard MC, ''et al.'' |title=Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia. |journal=Cancer Genet. Cytogenet. |volume=135 |issue= 2 |pages= 187-91 |year= 2002 |pmid= 12127405 |doi=  }}
+* {{cite journal | vauthors = Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y | title = hDOT1L links histone methylation to leukemogenesis | journal = Cell | volume = 121 | issue = 2 | pages = 167–78 | year = 2005 | pmid = 15851025 | doi = 10.1016/j.cell.2005.02.020 }}
-*{{cite journal  | author=Nakamura T, Mori T, Tada S, ''et al.'' |title=ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. |journal=Mol. Cell |volume=10 |issue= 5 |pages= 1119-28 |year= 2003 |pmid= 12453419 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Perrin L, Bloyer S, Ferraz C, ''et al.'' |title=The leucine zipper motif of the Drosophila AF10 homologue can inhibit PRE-mediated repression: implications for leukemogenic activity of human MLL-AF10 fusions. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 119-30 |year= 2003 |pmid= 12482966 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
-*{{cite journal  | author=Okada Y, Feng Q, Lin Y, ''et al.'' |title=hDOT1L links histone methylation to leukemogenesis. |journal=Cell |volume=121 |issue= 2 |pages= 167-78 |year= 2005 |pmid= 15851025 |doi= 10.1016/j.cell.2005.02.020 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-10-stub}}

MLLT10: Difference between revisions

Latest revision as of 06:38, 4 September 2017

Interactions

References

Further reading

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