MLF1: Difference between revisions

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{{Infobox_gene}}
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'''Myeloid leukemia factor 1''' is a [[protein]] that in humans is encoded by the ''MLF1'' [[gene]].<ref name="pmid8570204">{{cite journal |vauthors=Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW | title = The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1 | journal = Oncogene | volume = 12 | issue = 2 | pages = 265–75 |date=Mar 1996 | pmid = 8570204 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLF1 myeloid leukemia factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4291| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Myeloid leukemia factor 1
| HGNCid = 7125
| Symbol = MLF1
| AltSymbols =;
| OMIM = 601402
| ECnumber = 
| Homologene = 7839
| MGIid = 1341819
| GeneAtlas_image1 = PBB_GE_MLF1_204783_at_tn.png
| GeneAtlas_image2 = PBB_GE_MLF1_204784_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0002318 |text = myeloid progenitor cell differentiation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4291
    | Hs_Ensembl = ENSG00000178053
    | Hs_RefseqProtein = NP_071888
    | Hs_RefseqmRNA = NM_022443
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 159771677
    | Hs_GenLoc_end = 159807713
    | Hs_Uniprot = P58340
    | Mm_EntrezGene = 17349
    | Mm_Ensembl = ENSMUSG00000048416
    | Mm_RefseqmRNA = NM_001039543
    | Mm_RefseqProtein = NP_001034632
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 67462026
    | Mm_GenLoc_end = 67487932
    | Mm_Uniprot = Q3V042
  }}
}}
'''Myeloid leukemia factor 1''', also known as '''MLF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLF1 myeloid leukemia factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4291| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Yoneda-Kato N, Look AT, Kirstein MN, ''et al.'' |title=The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. |journal=Oncogene |volume=12 |issue= 2 |pages= 265-75 |year= 1996 |pmid= 8570204 |doi=  }}
*{{cite journal   |vauthors=Lim R, Winteringham LN, Williams JH, etal |title=MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40997–1008 |year= 2002 |pmid= 12176995 |doi= 10.1074/jbc.M206041200 }}
*{{cite journal  | author=Lim R, Winteringham LN, Williams JH, ''et al.'' |title=MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40997-1008 |year= 2002 |pmid= 12176995 |doi= 10.1074/jbc.M206041200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Arber DA, Chang KL, Lyda MH, etal |title=Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. |journal=Hum. Pathol. |volume=34 |issue= 8 |pages= 809–13 |year= 2003 |pmid= 14506644 |doi=10.1016/S0046-8177(03)00251-X }}
*{{cite journal | author=Arber DA, Chang KL, Lyda MH, ''et al.'' |title=Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia. |journal=Hum. Pathol. |volume=34 |issue= 8 |pages= 809-13 |year= 2003 |pmid= 14506644 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Hanissian SH, Akbar U, Teng B, etal |title=cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. |journal=Oncogene |volume=23 |issue= 20 |pages= 3700–7 |year= 2004 |pmid= 15116101 |doi= 10.1038/sj.onc.1207448 }}
*{{cite journal | author=Hanissian SH, Akbar U, Teng B, ''et al.'' |title=cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. |journal=Oncogene |volume=23 |issue= 20 |pages= 3700-7 |year= 2004 |pmid= 15116101 |doi= 10.1038/sj.onc.1207448 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Yoneda-Kato N, Tomoda K, Umehara M, etal |title=Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. |journal=EMBO J. |volume=24 |issue= 9 |pages= 1739–49 |year= 2005 |pmid= 15861129 |doi= 10.1038/sj.emboj.7600656 | pmc=1142586 }}
*{{cite journal | author=Yoneda-Kato N, Tomoda K, Umehara M, ''et al.'' |title=Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3. |journal=EMBO J. |volume=24 |issue= 9 |pages= 1739-49 |year= 2005 |pmid= 15861129 |doi= 10.1038/sj.emboj.7600656 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Yoneda-Kato N, Kato JY |title=Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. |journal=Mol. Cell. Biol. |volume=28 |issue= 1 |pages= 422–34 |year= 2008 |pmid= 17967869 |doi= 10.1128/MCB.02335-06 | pmc=2223285 }}
*{{cite journal  | author=Yoneda-Kato N, Kato JY |title=Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformation. |journal=Mol. Cell. Biol. |volume=28 |issue= 1 |pages= 422-34 |year= 2008 |pmid= 17967869 |doi= 10.1128/MCB.02335-06 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:37, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myeloid leukemia factor 1 is a protein that in humans is encoded by the MLF1 gene.[1][2]


References

  1. ↑ Yoneda-Kato N, Look AT, Kirstein MN, Valentine MB, Raimondi SC, Cohen KJ, Carroll AJ, Morris SW (Mar 1996). "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1". Oncogene. 12 (2): 265–75. PMID 8570204.
  2. ↑ "Entrez Gene: MLF1 myeloid leukemia factor 1".

Further reading



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