MKNK1

MAP kinase interacting serine/threonine kinase 1
File:PBB Protein MKNK1 image.jpg PDB rendering based on 2hw6.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hw6​
Identifiers
Symbols	MKNK1 ; MNK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37838
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MKNK1 209467 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MAP kinase interacting serine/threonine kinase 1, also known as MKNK1, is a human gene.

Further reading

• de Carvalho MG, McCormack AL, Olson E; et al. (1996). "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes". J. Biol. Chem. 271 (12): 6987–97. PMID 8636128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMID 9155017.CS1 maint: Multiple names: authors list (link)
• Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMID 9155018.
• Börsch-Haubold AG, Bartoli F, Asselin J; et al. (1998). "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells". J. Biol. Chem. 273 (8): 4449–58. PMID 9468497.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pyronnet S, Imataka H, Gingras AC; et al. (1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. PMID 9878069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Waskiewicz AJ, Johnson JC, Penn B; et al. (1999). "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. Cell. Biol. 19 (3): 1871–80. PMID 10022874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuesta R, Laroia G, Schneider RJ (2000). "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes". Genes Dev. 14 (12): 1460–70. PMID 10859165.CS1 maint: Multiple names: authors list (link)
• Hefner Y, Borsch-Haubold AG, Murakami M; et al. (2001). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". J. Biol. Chem. 275 (48): 37542–51. doi:10.1074/jbc.M003395200. PMID 10978317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMID 11154262.CS1 maint: Multiple names: authors list (link)
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMID 11463832.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reuter TY, Medhurst AL, Waisfisz Q; et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. PMID 14499622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuesta R, Xi Q, Schneider RJ (2004). "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein". J. Virol. 78 (14): 7707–16. doi:10.1128/JVI.78.14.7707-7716.2004. PMID 15220445.CS1 maint: Multiple names: authors list (link)
• Orton KC, Ling J, Waskiewicz AJ; et al. (2004). "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk". J. Biol. Chem. 279 (37): 38649–57. doi:10.1074/jbc.M407337200. PMID 15234964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Loghlen A, González VM, Piñeiro D; et al. (2004). "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1". Exp. Cell Res. 299 (2): 343–55. doi:10.1016/j.yexcr.2004.06.006. PMID 15350534.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Worch J, Tickenbrock L, Schwäble J; et al. (2005). "The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells". Oncogene. 23 (57): 9162–72. doi:10.1038/sj.onc.1208164. PMID 15516979.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC (2005). "Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells". J. Biol. Chem. 280 (6): 4772–8. doi:10.1074/jbc.M408356200. PMID 15563472.CS1 maint: Multiple names: authors list (link)
• O'Loghlen A, González VM, Salinas M, Martín ME (2005). "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells". FEBS Lett. 578 (1–2): 31–5. doi:10.1016/j.febslet.2004.10.063. PMID 15581611.CS1 maint: Multiple names: authors list (link)