MIP (gene)

Major intrinsic protein of lens fiber
File:PBB Protein MIP image.jpg PDB rendering based on 1sor.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1sor​, 1ymg​, 2b6o​, 2b6p​, 2c32​
Identifiers
Symbols	MIP ; LIM1; AQP0; MIP26; MP26
External IDs	Template:OMIM5 Template:MGI HomoloGene: 40627
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MIP 220863 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Major intrinsic protein of lens fiber, also known as MIP, is a human gene.

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.

Further reading

• Chepelinsky AB, Piatigorsky J, Pisano MM; et al. (1991). "Lens protein gene expression: alpha-crystallins and MIP". Lens and eye toxicity research. 8 (2–3): 319–44. PMID 1911643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Griffin CS, Shiels A (1992). "In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14". Cytogenet. Cell Genet. 61 (1): 8–9. PMID 1505237.
• Girsch SJ, Peracchia C (1992). "Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26". Curr. Eye Res. 10 (9): 839–49. PMID 1790714.
• Pisano MM, Chepelinsky AB (1992). "Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens". Genomics. 11 (4): 981–90. PMID 1840563.
• Lampe PD, Johnson RG (1991). "Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes". Eur. J. Biochem. 194 (2): 541–7. PMID 2176601.
• Manenti S, Dunia I, Benedetti EL (1990). "Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated". FEBS Lett. 262 (2): 356–8. PMID 2335219.CS1 maint: Multiple names: authors list (link)
• Peracchia C, Girsch SJ (1991). "Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26". Lens and eye toxicity research. 6 (4): 613–21. PMID 2487274.
• Saito F, Sasaki S, Chepelinsky AB; et al. (1994). "Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH". Cytogenet. Cell Genet. 68 (1–2): 45–8. PMID 7525161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mulders SM, Preston GM, Deen PM; et al. (1995). "Water channel properties of major intrinsic protein of lens". J. Biol. Chem. 270 (15): 9010–16. PMID 7536742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jarvis LJ, Louis CF (1996). "Purification and oligomeric state of the major lens fiber cell membrane proteins". Curr. Eye Res. 14 (9): 799–808. PMID 8529419.
• Wang XY, Ohtaka-Maruyama C, Pisano MM; et al. (1996). "Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene". Gene. 167 (1–2): 321–5. PMID 8566800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Prabhakaram M, Katz ML, Ortwerth BJ (1997). "Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes". Mech. Ageing Dev. 91 (1): 65–78. PMID 8910261.CS1 maint: Multiple names: authors list (link)
• Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.CS1 maint: Multiple names: authors list (link)
• Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB (1998). "Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene". Nucleic Acids Res. 26 (2): 407–14. PMID 9421492.CS1 maint: Multiple names: authors list (link)
• Dunia I, Recouvreur M, Nicolas P; et al. (1998). "Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling". J. Cell. Sci. 111 ( Pt 15): 2109–20. PMID 9664032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schey KL, Fowler JG, Shearer TR, David L (1999). "Modifications to rat lens major intrinsic protein in selenite-induced cataract". Invest. Ophthalmol. Vis. Sci. 40 (3): 657–67. PMID 10067969.CS1 maint: Multiple names: authors list (link)
• Schey KL, Little M, Fowler JG, Crouch RK (2000). "Characterization of human lens major intrinsic protein structure". Invest. Ophthalmol. Vis. Sci. 41 (1): 175–82. PMID 10634618.CS1 maint: Multiple names: authors list (link)
• Berry V, Francis P, Kaushal S; et al. (2000). "Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q". Nat. Genet. 25 (1): 15–7. doi:10.1038/75538. PMID 10802646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)