MEF2C

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MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)
File:PBB Protein MEF2C image.jpg
PDB rendering based on 1c7u.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols MEF2C ;
External IDs Template:OMIM5 Template:MGI HomoloGene: 31087
RNA expression pattern
File:PBB GE MEF2C 209199 s at tn.png
File:PBB GE MEF2C 207968 s at tn.png
File:PBB GE MEF2C 209200 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C), also known as MEF2C, is a transcription factor in the Mef2 family.[1][2] The Mef2c gene is necessary for proper embryonic development: mice without a functional copy of the Mef2c gene die before birth and have abnormalities in the heart and vascular system.[3]


See also

References

  1. ↑ Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C". Mol Cell Biol. 16 (6): 2627–36. PMID 8649370.
  2. ↑ "Entrez Gene: MEF2C myocyte enhancer factor 2C".
  3. ↑ Bi W, Drake CJ, Schwarz JJ (1999). "The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF". Developmental Biology. 211 (2): 255–67. PMID 10395786.

Further reading

  • Leifer D, Krainc D, Yu YT; et al. (1993). "MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1546–50. PMID 7679508.
  • McDermott JC, Cardoso MC, Yu YT; et al. (1993). "hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors". Mol. Cell. Biol. 13 (4): 2564–77. PMID 8455629.
  • Hobson GM, Krahe R, Garcia E; et al. (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–11. doi:10.1006/geno.1995.9007. PMID 8575763.
  • Krainc D, Haas M, Ward DC; et al. (1996). "Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved". Genomics. 29 (3): 809–11. doi:10.1006/geno.1995.9927. PMID 8575784.
  • Molkentin JD, Li L, Olson EN (1996). "Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity". J. Biol. Chem. 271 (29): 17199–204. PMID 8663403.
  • Black BL, Ligon KL, Zhang Y, Olson EN (1996). "Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family". J. Biol. Chem. 271 (43): 26659–63. PMID 8900141.
  • Gradwohl G, Fode C, Guillemot F (1997). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.
  • Sartorelli V, Huang J, Hamamori Y, Kedes L (1997). "Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C". Mol. Cell. Biol. 17 (2): 1010–26. PMID 9001254.
  • Han J, Jiang Y, Li Z; et al. (1997). "Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation". Nature. 386 (6622): 296–9. doi:10.1038/386296a0. PMID 9069290.
  • Kato Y, Kravchenko VV, Tapping RI; et al. (1998). "BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C". EMBO J. 16 (23): 7054–66. doi:10.1093/emboj/16.23.7054. PMID 9384584.
  • Krainc D, Bai G, Okamoto S; et al. (1998). "Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1". J. Biol. Chem. 273 (40): 26218–24. PMID 9748305.
  • Yang CC, Ornatsky OI, McDermott JC; et al. (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. PMID 9753748.
  • Swanson BJ, Jäck HM, Lyons GE (1998). "Characterization of myocyte enhancer factor 2 (MEF2) expression in B and T cells: MEF2C is a B cell-restricted transcription factor in lymphocytes". Mol. Immunol. 35 (8): 445–58. PMID 9798649.
  • Zhao M, New L, Kravchenko VV; et al. (1999). "Regulation of the MEF2 family of transcription factors by p38". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528.
  • Wilson-Rawls J, Molkentin JD, Black BL, Olson EN (1999). "Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C". Mol. Cell. Biol. 19 (4): 2853–62. PMID 10082551.
  • Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors". Mol. Cell. Biol. 19 (6): 4028–38. PMID 10330143.
  • Wang AH, Bertos NR, Vezmar M; et al. (1999). "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor". Mol. Cell. Biol. 19 (11): 7816–27. PMID 10523670.
  • Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. doi:10.1073/pnas.080064097. PMID 10737771.
  • Morin S, Charron F, Robitaille L, Nemer M (2000). "GATA-dependent recruitment of MEF2 proteins to target promoters". EMBO J. 19 (9): 2046–55. doi:10.1093/emboj/19.9.2046. PMID 10790371.
  • Wu Z, Woodring PJ, Bhakta KS; et al. (2000). "p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps". Mol. Cell. Biol. 20 (11): 3951–64. PMID 10805738.

External links


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