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{{ | '''Mediator of RNA polymerase II transcription subunit 7''' is an [[enzyme]] that in humans is encoded by the ''MED7'' [[gene]].<ref name="pmid9989412">{{cite journal |vauthors=Ryu S, Zhou S, Ladurner AG, Tjian R | title = The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1 | journal = Nature | volume = 397 | issue = 6718 | pages = 446–50 |date=Feb 1999 | pmid = 9989412 | pmc = | doi = 10.1038/17141 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9443| accessdate = }}</ref> | ||
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| summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.<ref name="entrez">{{cite web | title = Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa| url = | | summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.<ref name="entrez">{{cite web | title = Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9443| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sato S, Tomomori-Sato C, Parmely TJ, etal |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }} | ||
*{{cite journal | *{{cite journal |vauthors=Tomomori-Sato C, Sato S, Parmely TJ, etal |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sato S, Tomomori-Sato C, Banks CA, etal |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123–7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Ryu S, Tjian R |title=Purification of transcription cofactor complex CRSP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7137–42 |year= 1999 |pmid= 10377381 |doi=10.1073/pnas.96.13.7137 | pmc=22029 }} | ||
*{{cite journal | *{{cite journal |vauthors=Näär AM, Beaurang PA, Zhou S, etal |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jiang YW, Veschambre P, Erdjument-Bromage H, etal |title=Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8538–43 |year= 1998 |pmid= 9671713 |doi=10.1073/pnas.95.15.8538 | pmc=21111 }} | ||
*{{cite journal |vauthors=Myers LC, Gustafsson CM, Bushnell DA, etal |title=The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. |journal=Genes Dev. |volume=12 |issue= 1 |pages= 45–54 |year= 1998 |pmid= 9420330 |doi=10.1101/gad.12.1.45 | pmc=316402 }} | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Latest revision as of 06:21, 4 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene.[1][2]
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.[2]
References
- ↑ Ryu S, Zhou S, Ladurner AG, Tjian R (Feb 1999). "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1". Nature. 397 (6718): 446–50. doi:10.1038/17141. PMID 9989412.
- ↑ 2.0 2.1 "Entrez Gene: CRSP9 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa".
Further reading
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Mol. Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
- Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
- Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP". Proc. Natl. Acad. Sci. U.S.A. 96 (13): 7137–42. doi:10.1073/pnas.96.13.7137. PMC 22029. PMID 10377381.
- Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
- Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8538–43. doi:10.1073/pnas.95.15.8538. PMC 21111. PMID 9671713.
- Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain". Genes Dev. 12 (1): 45–54. doi:10.1101/gad.12.1.45. PMC 316402. PMID 9420330.
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