MAPK4

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Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene.^[1]^[2]

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets.^[2]

The Arabidopsis MAPK4 is important in signalling ^[3]

References

↑ Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.
↑ ^2.0 ^2.1 "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".
↑ Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, Nielsen HB, Lacy M, Austin MJ, Parker JE, Sharma SB, Klessig DF, Martienssen R, Mattsson O, Jensen AB & Mundy J (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell. 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186.

External links

MAP Kinase Resource .

Seger R, Krebs EG (1995). "The MAPK signaling cascade". FASEB J. 9 (9): 726–35. PMID 7601337.
Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
Robinson MJ, Cobb MH (1997). "Mitogen-activated protein kinase pathways". Curr. Opin. Cell Biol. 9 (2): 180–6. doi:10.1016/S0955-0674(97)80061-0. PMID 9069255.
Gonzalez FA, Raden DL, Rigby MR, Davis RJ (1992). "Heterogeneous expression of four MAP kinase isoforms in human tissues". FEBS Lett. 304 (2–3): 170–8. doi:10.1016/0014-5793(92)80612-K. PMID 1319925.
Zhu AX, Zhao Y, Moller DE, Flier JS (1994). "Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3". Mol. Cell. Biol. 14 (12): 8202–11. PMC 359359. PMID 7969157.
Kinet S, Bernard F, Mongellaz C, et al. (2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. doi:10.1182/blood-2002-03-0819. PMID 12239168.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sun M, Wei Y, Yao L, et al. (2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3". Biochem. Biophys. Res. Commun. 340 (1): 209–14. doi:10.1016/j.bbrc.2005.12.003. PMID 16360641.
Kant S, Schumacher S, Singh MK, et al. (2007). "Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5". J. Biol. Chem. 281 (46): 35511–9. doi:10.1074/jbc.M606693200. PMID 16973613.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by expanding it.

[pmid8290275-1] Li L, Wysk M, Gonzalez FA, Davis RJ (Feb 1994). "Genomic loci of human mitogen-activated protein kinases". Oncogene. 9 (2): 647–9. PMID 8290275.

[entrez-2] 2.0 ^2.1 "Entrez Gene: MAPK4 mitogen-activated protein kinase 4".

[3] Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, Nielsen HB, Lacy M, Austin MJ, Parker JE, Sharma SB, Klessig DF, Martienssen R, Mattsson O, Jensen AB & Mundy J (2000). "Arabidopsis MAP Kinase 4 Negatively Regulates Systemic Acquired Resistance". Cell. 103 (7): 1111–1120. doi:10.1016/S0092-8674(00)00213-0. PMID 11163186.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

MAPK4

References

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