MAPK1

Mitogen-activated protein kinase 1, also known as MAPK1, is a human gene.

Mitogen-activated protein kinase 1
File:PBB Protein MAPK1 image.jpg PDB rendering based on 1erk.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1erk​, 1gol​, 1pme​, 1tvo​, 1wzy​, 2erk​, 2fys​, 2gph​, 2ojg​, 2oji​, 2ojj​, 3erk​, 4erk​
Identifiers
Symbols	MAPK1 ; p38; ERK; p40; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p41; p41mapk
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37670
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAPK1 212271 at.png
File:PBB GE MAPK1 208351 s at.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Further reading

• Morishima-Kawashima M, Hasegawa M, Takio K; et al. (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging. 16 (3): 365–71, discussion 371-80. PMID 7566346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977.
• Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2: 91–6. doi:10.1080/13550280290167885. PMID 12491158.CS1 maint: Multiple names: authors list (link)
• Greenway AL, Holloway G, McPhee DA; et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. PMID 12734410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918.