MAP3K12

Mitogen-activated protein kinase kinase kinase 12
Identifiers
Symbols	MAP3K12 ; DLK; MUK; ZPK; ZPKP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4592
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP3K12 205447 s at tn.png
File:PBB GE MAP3K12 205448 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase kinase kinase 12, also known as MAP3K12, is a human gene.

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.

Further reading

• Reddy UR, Nycum L, Slavc I, Biegel JA (1995). "Localization of the human zipper protein kinase gene (ZPK) to chromosome 12q13 by fluorescence in situ hybridization and somatic cell hybrid analysis". Genomics. 25 (2): 597–8. PMID 7790002.CS1 maint: Multiple names: authors list (link)
• Holzman LB, Merritt SE, Fan G (1995). "Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases". J. Biol. Chem. 269 (49): 30808–17. PMID 7983011.CS1 maint: Multiple names: authors list (link)
• Reddy UR, Pleasure D (1994). "Cloning of a novel putative protein kinase having a leucine zipper domain from human brain". Biochem. Biophys. Res. Commun. 202 (1): 613–20. doi:10.1006/bbrc.1994.1972. PMID 8037767.
• Hirai S, Izawa M, Osada S; et al. (1996). "Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK". Oncogene. 12 (3): 641–50. PMID 8637721.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mata M, Merritt SE, Fan G; et al. (1996). "Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin". J. Biol. Chem. 271 (28): 16888–96. PMID 8663324.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakuma H, Ikeda A, Oka S; et al. (1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J. Biol. Chem. 272 (45): 28622–9. PMID 9353328.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Merritt SE, Mata M, Nihalani D; et al. (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate". J. Biol. Chem. 274 (15): 10195–202. PMID 10187804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Reddy UR, Basu A, Bannerman P; et al. (1999). "ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation". Oncogene. 18 (31): 4474–84. doi:10.1038/sj.onc.1202813. PMID 10442638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Douziech M, Laberge G, Grondin G; et al. (1999). "Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells". J. Histochem. Cytochem. 47 (10): 1287–96. PMID 10490457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuyama K, Yoshida M, Yamashita A; et al. (2000). "MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper protein kinase". J. Biol. Chem. 275 (28): 21247–54. doi:10.1074/jbc.M001488200. PMID 10801814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hébert SS, Daviau A, Grondin G; et al. (2000). "The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis". J. Biol. Chem. 275 (42): 32482–90. doi:10.1074/jbc.M006528200. PMID 10922377.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.CS1 maint: Multiple names: authors list (link)
• Itoh A, Wang Z, Ito Y; et al. (2004). "SP3 acts as a positive regulator on the core promoter of human ZPK gene". Biochem. Biophys. Res. Commun. 313 (3): 612–8. PMID 14697235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Graves PR, Winkfield KM, Haystead TA (2005). "Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation". J. Biol. Chem. 280 (10): 9363–74. doi:10.1074/jbc.M412538200. PMID 15611134.CS1 maint: Multiple names: authors list (link)
• Robitaille H, Proulx R, Robitaille K; et al. (2005). "The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation". J. Biol. Chem. 280 (13): 12732–41. doi:10.1074/jbc.M411619200. PMID 15695824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)