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{{Infobox_gene}}
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'''Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3''' is an [[enzyme]] that in humans is encoded by the ''MAGI3'' [[gene]].<ref name="pmid10997877">{{cite journal |vauthors=Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 4 | pages = 273–81 |date=Dec 2000 | pmid = 10997877 | pmc =  | doi = 10.1093/dnares/7.4.271}}</ref><ref name="pmid10748157">{{cite journal |vauthors=Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA | title = Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | journal = J Biol Chem | volume = 275 | issue = 28 | pages = 21477–85 |date=Aug 2000 | pmid = 10748157 | pmc =  | doi = 10.1074/jbc.M909741199 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=260425| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Membrane associated guanylate kinase, WW and PDZ domain containing 3
| HGNCid = 29647
| Symbol = MAGI3
| AltSymbols =; MAGI-3; MGC163281; RP4-730K3.1; dJ730K3.2
| OMIM = 
| ECnumber = 
| Homologene = 26431
| MGIid = 1923484
| Function = {{GNF_GO|id=GO:0004385 |text = guanylate kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 260425
    | Hs_Ensembl = ENSG00000081026
    | Hs_RefseqProtein = NP_066016
    | Hs_RefseqmRNA = NM_020965
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 113734894
    | Hs_GenLoc_end = 114030068
    | Hs_Uniprot =   
    | Mm_EntrezGene = 99470
    | Mm_Ensembl = ENSMUSG00000052539
    | Mm_RefseqmRNA = NM_133853
    | Mm_RefseqProtein = NP_598614
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 104144030
    | Mm_GenLoc_end = 104349088
    | Mm_Uniprot = 
  }}
}}
'''Membrane associated guanylate kinase, WW and PDZ domain containing 3''', also known as '''MAGI3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=260425| accessdate = }}</ref>


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==Interactions==
MAGI3 has been shown to [[Protein-protein interaction|interact]] with [[PTPRB]]<ref name=pmid12615970>{{cite journal |doi=10.1242/jcs.00302 |last=Adamsky |first=Konstantin |authorlink= |author2=Arnold Katya |author3=Sabanay Helena |author4=Peles Elior  |date=Apr 2003 |title=Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins |journal=J. Cell Sci. |volume=116 |issue=Pt 7 |pages=1279–89 |publisher= |location = England| issn = 0021-9533| pmid = 12615970 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PTEN (gene)|PTEN]].<ref name=pmid10748157 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Zhang H, Wang D, Sun H, ''et al.'' |title=MAGI-3 regulates LPA-induced activation of Erk and RhoA. |journal=Cell. Signal. |volume=19 |issue= 2 |pages= 261-8 |year= 2007 |pmid= 16904289 |doi= 10.1016/j.cellsig.2006.06.008 }}
*{{cite journal   |vauthors=Zhang H, Wang D, Sun H, etal |title=MAGI-3 regulates LPA-induced activation of Erk and RhoA. |journal=Cell. Signal. |volume=19 |issue= 2 |pages= 261–8 |year= 2007 |pmid= 16904289 |doi= 10.1016/j.cellsig.2006.06.008 | pmc=1995035 }}
*{{cite journal | author=He J, Bellini M, Inuzuka H, ''et al.'' |title=Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2820-7 |year= 2006 |pmid= 16316992 |doi= 10.1074/jbc.M509503200 }}
*{{cite journal   |vauthors=He J, Bellini M, Inuzuka H, etal |title=Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. |journal=J. Biol. Chem. |volume=281 |issue= 5 |pages= 2820–7 |year= 2006 |pmid= 16316992 |doi= 10.1074/jbc.M509503200 }}
*{{cite journal | author=Franklin JL, Yoshiura K, Dempsey PJ, ''et al.'' |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457-70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }}
*{{cite journal   |vauthors=Franklin JL, Yoshiura K, Dempsey PJ, etal |title=Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. |journal=Exp. Cell Res. |volume=303 |issue= 2 |pages= 457–70 |year= 2005 |pmid= 15652357 |doi= 10.1016/j.yexcr.2004.10.007 }}
*{{cite journal  | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023-30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal  |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Adamsky K, Arnold K, Sabanay H, Peles E |title=Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. |journal=J. Cell. Sci. |volume=116 |issue= Pt 7 |pages= 1279-89 |year= 2003 |pmid= 12615970 |doi=  }}
*{{cite journal  |vauthors=Adamsky K, Arnold K, Sabanay H, Peles E |title=Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins. |journal=J. Cell Sci. |volume=116 |issue= Pt 7 |pages= 1279–89 |year= 2003 |pmid= 12615970 |doi=10.1242/jcs.00302 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  |vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal | author=Thomas M, Laura R, Hepner K, ''et al.'' |title=Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. |journal=Oncogene |volume=21 |issue= 33 |pages= 5088-96 |year= 2002 |pmid= 12140759 |doi= 10.1038/sj.onc.1205668 }}
*{{cite journal   |vauthors=Thomas M, Laura R, Hepner K, etal |title=Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. |journal=Oncogene |volume=21 |issue= 33 |pages= 5088–96 |year= 2002 |pmid= 12140759 |doi= 10.1038/sj.onc.1205668 }}
*{{cite journal  | author=Laura RP, Ross S, Koeppen H, Lasky LA |title=MAGI-1: a widely expressed, alternatively spliced tight junction protein. |journal=Exp. Cell Res. |volume=275 |issue= 2 |pages= 155-70 |year= 2002 |pmid= 11969287 |doi= 10.1006/excr.2002.5475 }}
*{{cite journal  |vauthors=Laura RP, Ross S, Koeppen H, Lasky LA |title=MAGI-1: a widely expressed, alternatively spliced tight junction protein. |journal=Exp. Cell Res. |volume=275 |issue= 2 |pages= 155–70 |year= 2002 |pmid= 11969287 |doi= 10.1006/excr.2002.5475 }}
*{{cite journal  | author=Nagase T, Kikuno R, Nakayama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 4 |pages= 273-81 |year= 2001 |pmid= 10997877 |doi=  }}
*{{cite journal  | author=Wu Y, Dowbenko D, Spencer S, ''et al.'' |title=Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21477-85 |year= 2000 |pmid= 10748157 |doi= 10.1074/jbc.M909741199 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:36, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.[1][2][3]


Interactions

MAGI3 has been shown to interact with PTPRB[4] and PTEN.[2]

References

  1. ↑ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  2. ↑ 2.0 2.1 Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Aug 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J Biol Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
  3. ↑ "Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3".
  4. ↑ Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell Sci. England. 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. ISSN 0021-9533. PMID 12615970.

Further reading



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