MAGEA2

Melanoma antigen family A, 2
Identifiers
Symbols	MAGEA2 ; MAGE2; MAGEA2A; MGC131923; MAGEA2; MGC16973
External IDs	Template:OMIM5 HomoloGene: 18781
Gene ontology
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Melanoma antigen family A, 2, also known as MAGEA2, is a human gene.

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Further reading

• van der Bruggen P, Traversari C, Chomez P; et al. (1992). "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science. 254 (5038): 1643–7. PMID 1840703.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brasseur F, Rimoldi D, Liénard D; et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80. PMID 7591235.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Plaen E, Arden K, Traversari C; et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. PMID 7927540.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaugler B, Van den Eynde B, van der Bruggen P; et al. (1994). "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30. PMID 8113684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Smet C, Lurquin C, van der Bruggen P; et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9. PMID 8276455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zakut R, Topalian SL, Kawakami Y; et al. (1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 (1): 5–8. PMID 8416750.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rogner UC, Wilke K, Steck E; et al. (1996). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mallon AM, Platzer M, Bate R; et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. PMID 10854409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagao T, Higashitsuji H, Nonoguchi K; et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. PMID 12525503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Monte M, Simonatto M, Peche LY; et al. (2006). "MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents". Proc. Natl. Acad. Sci. U.S.A. 103 (30): 11160–5. doi:10.1073/pnas.0510834103. PMID 16847267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wischnewski F, Friese O, Pantel K, Schwarzenbach H (2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Mol. Cancer Res. 5 (7): 749–59. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.CS1 maint: Multiple names: authors list (link)