MAF (gene)
| V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | MAF ; MGC71685 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 74552 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MAF 206363 at tn.png | |||||||||||
| File:PBB GE MAF 209347 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
MAF (V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)), is a transcription factor, but also denotes the human gene encoding it.[1]
Types
One type, MafA, also known as RIPE3b1[2], promotes pancreatic development, as well as insulin gene transcription[3]
References
- ↑ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)".
- ↑ Olbrot M, Rud J, Moss LG, Sharma A (2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6737–42. doi:10.1073/pnas.102168499. PMID 12011435.
- ↑ Melloul et al., Diabetologica, 45, 309-326, year 2002. Regulation of insulin gene transcription
Further reading
- Kerppola TK, Curran T (1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun". Oncogene. 9 (3): 675–84. PMID 8108109.
- Kurschner C, Morgan JI (1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochem. Biophys. Res. Commun. 231 (2): 333–9. doi:10.1006/bbrc.1997.6097. PMID 9070273.
- Hedge SP, Kumar A, Kurschner C, Shapiro LH (1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Mol. Cell. Biol. 18 (5): 2729–37. PMID 9566892.
- Chesi M, Bergsagel PL, Shonukan OO; et al. (1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Blood. 91 (12): 4457–63. PMID 9616139.
- Christodoulopoulos P, Cameron L, Nakamura Y; et al. (2001). "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression". J. Allergy Clin. Immunol. 107 (4): 586–91. doi:10.1067/mai.2001.114883. PMID 11295643.
- Jamieson RV, Perveen R, Kerr B; et al. (2002). "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma". Hum. Mol. Genet. 11 (1): 33–42. PMID 11772997.
- Chen Q, Dowhan DH, Liang D; et al. (2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
- Dhakshinamoorthy S, Jaiswal AK (2002). "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene. 21 (34): 5301–12. doi:10.1038/sj.onc.1205642. PMID 12149651.
- Cousins DJ, Lee TH, Staynov DZ (2002). "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines". J. Immunol. 169 (5): 2498–506. PMID 12193719.
- Huang W, Lu N, Eberspaecher H, De Crombrugghe B (2003). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". J. Biol. Chem. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice". Mol. Vis. 9: 288–94. PMID 12835653.
- Grimbert P, Valanciute A, Audard V; et al. (2003). "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization". J. Exp. Med. 198 (5): 797–807. doi:10.1084/jem.20030566. PMID 12939343.
- Valanciuté A, le Gouvello S, Solhonne B; et al. (2004). "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome". J. Immunol. 172 (1): 688–98. PMID 14688382.
- Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (2004). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance". Leuk. Lymphoma. 44 (10): 1761–6. PMID 14692531.
- Hurt EM, Wiestner A, Rosenwald A; et al. (2004). "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma". Cancer Cell. 5 (2): 191–9. PMID 14998494.
- Cao S, Liu J, Song L, Ma X (2005). "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages". J. Immunol. 174 (6): 3484–92. PMID 15749884.
- Morito N, Yoh K, Fujioka Y; et al. (2006). "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human". Cancer Res. 66 (2): 812–9. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013.
- Vanita V, Singh D, Robinson PN; et al. (2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family". Am. J. Med. Genet. A. 140 (6): 558–66. doi:10.1002/ajmg.a.31126. PMID 16470690.
External links
- MAF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.