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{{Infobox_gene}}
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''Lymphoid enhancer-binding factor 1''' ('''LEF1''') is a [[protein]] that in humans is encoded by the ''LEF1'' [[gene]].<ref name="pmid1783375">{{cite journal |vauthors=Milatovich A, Travis A, Grosschedl R, Francke U | title = Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf | journal = Genomics | volume = 11 | issue = 4 | pages = 1040–8 |date=Mar 1992 | pmid = 1783375 | pmc =  | doi =10.1016/0888-7543(91)90030-I }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_LEF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2lef.
| PDB = {{PDB2|2lef}}
| Name = Lymphoid enhancer-binding factor 1
| HGNCid = 6551
| Symbol = LEF1
| AltSymbols =; DKFZp586H0919; TCF1ALPHA
| OMIM = 153245
| ECnumber =
| Homologene = 7813
| MGIid = 96770
| GeneAtlas_image1 = PBB_GE_LEF1_221558_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_LEF1_210948_s_at_tn.png
  | GeneAtlas_image3 = PBB_GE_LEF1_221557_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003705 |text = RNA polymerase II transcription factor activity, enhancer binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008301 |text = DNA bending activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001756 |text = somitogenesis}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048468 |text = cell development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51176
    | Hs_Ensembl = ENSG00000138795
    | Hs_RefseqProtein = NP_057353
    | Hs_RefseqmRNA = NM_016269
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 109188150
    | Hs_GenLoc_end = 109309027
    | Hs_Uniprot = Q9UJU2
    | Mm_EntrezGene = 16842
    | Mm_Ensembl = ENSMUSG00000027985
    | Mm_RefseqmRNA = NM_010703
    | Mm_RefseqProtein = NP_034833
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 131099626
    | Mm_GenLoc_end = 131213476
    | Mm_Uniprot = Q3TYB0
  }}
}}
'''Lymphoid enhancer-binding factor 1''', also known as '''LEF1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
 
| section_title =
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-[[B cell|B]] and [[T cell]]s. It binds to a functionally important site in the T-cell receptor-alpha ([[TRA@|TCRA]]) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 ([[HMGB1|HMG1]]).<ref name="entrez">{{cite web | title = Entrez Gene: LEF1 lymphoid enhancer-binding factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51176| accessdate = }}</ref>
| summary_text = Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: LEF1 lymphoid enhancer-binding factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51176| accessdate = }}</ref>
 
}}
== Clinical significance ==
 
LEF1 is highly overexpressed and associated with disease progression and poor prognosis in [[B-cell chronic lymphocytic leukemia]]<ref name = "Erdfelder et al.">{{cite journal |vauthors=Erdfelder F, Hertweck M, Filipovich A, Uhrmacher S, Kreuzer KA | title = High lymphoid enhancer- binding factor-1 expression is associated with disease progression and poor prognosis in chronic lymphocytic leukemia| journal = Hematology Reports| volume = 2| issue = 1| page =  3| year = 2010 | month = | pmid = | pmc = | doi = 10.4081/hr.2010.e3| url = http://www.pagepress.org/journals/index.php/hr/article/view/hr.2010.e3 | issn = }}</ref> and other kinds of malignancies like [[colorectal cancer]].<ref name="Eskandari et.al">{{cite journal |vauthors=Eskandari E, Mahjoubi F, Motalebzadeh J |title=An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers |journal=Gene |date=30 December 2018 |volume=679 |page=150-159 |doi=10.1016/j.gene.2018.09.003 |pmid=30193961 |url=https://www.ncbi.nlm.nih.gov/pubmed/30193961}}</ref> It is also a promising potential drug target.<ref name="pmid20360943">{{cite journal |vauthors=Gandhirajan RK, Staib PA, Minke K, Gehrke I, Plickert G, Schlösser A, Schmitt EK, Hallek M, Kreuzer KA | title = Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo | journal = Neoplasia | volume = 12 | issue = 4 | pages = 326–35 |date=April 2010 | pmid = 20360943 | pmc = 2847740 | doi = 10.1593/neo.91972 }}</ref>
 
==Interactions==
Lymphoid enhancer-binding factor 1 has been shown to [[Protein-protein interaction|interact]] with:
* [[ALX4]],<ref name="pmid11696550">{{cite journal |vauthors=Boras K, Hamel PA | title = Alx4 binding to LEF-1 regulates N-CAM promoter activity | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1120–7 |date=January 2002 | pmid = 11696550 | doi = 10.1074/jbc.M109912200 }}</ref>
* [[Runt-related transcription factor 1|AML-1]],<ref name="pmid10617663">{{cite journal |vauthors=Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW | title = A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia | journal = J. Biol. Chem. | volume = 275 | issue = 1 | pages = 651–6 |date=January 2000 | pmid = 10617663 | doi =10.1074/jbc.275.1.651 }}</ref>
* [[Beta-catenin|CTNNB1]],<ref name="pmid15684397">{{cite journal |vauthors=Edlund S, Lee SY, Grimsby S, Zhang S, Aspenström P, Heldin CH, Landström M | title = Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis | journal = Mol. Cell. Biol. | volume = 25 | issue = 4 | pages = 1475–88 |date=February 2005 | pmid = 15684397 | pmc = 548008 | doi = 10.1128/MCB.25.4.1475-1488.2005 }}</ref><ref name="pmid12748295">{{cite journal |vauthors=Grueneberg DA, Pablo L, Hu KQ, August P, Weng Z, Papkoff J | title = A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway | journal = Mol. Cell. Biol. | volume = 23 | issue = 11 | pages = 3936–50 |date=June 2003 | pmid = 12748295 | pmc = 155208 | doi =10.1128/MCB.23.11.3936-3950.2003 }}</ref><ref name="pmid8757136">{{cite journal |vauthors=Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W | title = Functional interaction of beta-catenin with the transcription factor LEF-1 | journal = Nature | volume = 382 | issue = 6592 | pages = 638–42 |date=August 1996 | pmid = 8757136 | doi = 10.1038/382638a0 }}</ref><ref name="pmid10890911">{{cite journal |vauthors=Labbé E, Letamendia A, Attisano L | title = Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 15 | pages = 8358–63 |date=July 2000 | pmid = 10890911 | pmc = 26952 | doi = 10.1073/pnas.150152697 }}</ref>
* [[EP300]],<ref name="pmid12446687">{{cite journal |vauthors=Hecht A, Stemmler MP | title = Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4 | journal = J. Biol. Chem. | volume = 278 | issue = 6 | pages = 3776–85 |date=February 2003 | pmid = 12446687 | doi = 10.1074/jbc.M210081200 }}</ref>
* [[Microphthalmia-associated transcription factor|MITF]]<ref name="pmid12032083">{{cite journal |vauthors=Yasumoto K, Takeda K, Saito H, Watanabe K, Takahashi K, Shibahara S | title = Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling | journal = EMBO J. | volume = 21 | issue = 11 | pages = 2703–14 |date=June 2002 | pmid = 12032083 | pmc = 126018 | doi = 10.1093/emboj/21.11.2703 }}</ref>
* [[PIAS4]],<ref name="pmid11731474">{{cite journal |vauthors=Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R | title = PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies | journal = Genes Dev. | volume = 15 | issue = 23 | pages = 3088–103 |date=December 2001 | pmid = 11731474 | pmc = 312834 | doi =10.1101/gad.944801 }}</ref>
* [[Mothers against decapentaplegic homolog 2|SMAD2]],<ref name=pmid10890911/> and
* [[Mothers against decapentaplegic homolog 3|SMAD3]].<ref name=pmid10890911/>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin|2}}
{{PBB_Further_reading
*{{cite journal  | author=Waterman ML |title=Lymphoid enhancer factor/T cell factor expression in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1–2 |pages= 41–52 |year= 2004 |pmid= 15000148 |doi=10.1023/A:1025858928620|url=https://zenodo.org/record/895454 }}
| citations =
*{{cite journal  |vauthors=Skokowa J, Welte K |title=LEF-1 is a decisive transcription factor in neutrophil granulopoiesis |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue=  |pages= 143–51 |year= 2007 |pmid= 17360796 |doi= 10.1196/annals.1392.012 }}
*{{cite journal  | author=Waterman ML |title=Lymphoid enhancer factor/T cell factor expression in colorectal cancer. |journal=Cancer Metastasis Rev. |volume=23 |issue= 1-2 |pages= 41-52 |year= 2004 |pmid= 15000148 |doi=  }}
*{{cite journal  |vauthors=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880–94 |year= 1991 |pmid= 1827423 |doi=10.1101/gad.5.5.880 }}
*{{cite journal  | author=Skokowa J, Welte K |title=LEF-1 is a decisive transcription factor in neutrophil granulopoiesis. |journal=Ann. N. Y. Acad. Sci. |volume=1106 |issue=  |pages= 143-51 |year= 2007 |pmid= 17360796 |doi= 10.1196/annals.1392.012 }}
*{{cite journal  |vauthors=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box |journal=EMBO J. |volume=10 |issue= 1 |pages= 123–32 |year= 1991 |pmid= 1989880 |doi= | pmc=452620 }}
*{{cite journal  | author=Milatovich A, Travis A, Grosschedl R, Francke U |title=Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. |journal=Genomics |volume=11 |issue= 4 |pages= 1040-8 |year= 1992 |pmid= 1783375 |doi=  }}
*{{cite journal  |vauthors=Waterman ML, Fischer WH, Jones KA |title=A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer |journal=Genes Dev. |volume=5 |issue= 4 |pages= 656–69 |year= 1991 |pmid= 2010090 |doi=10.1101/gad.5.4.656  }}
*{{cite journal  | author=Travis A, Amsterdam A, Belanger C, Grosschedl R |title=LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected] |journal=Genes Dev. |volume=5 |issue= 5 |pages= 880-94 |year= 1991 |pmid= 1827423 |doi=  }}
*{{cite journal  |vauthors=Zhou P, Byrne C, Jacobs J, Fuchs E |title=Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate |journal=Genes Dev. |volume=9 |issue= 6 |pages= 700–13 |year= 1995 |pmid= 7537238 |doi=10.1101/gad.9.6.700 }}
*{{cite journal  | author=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123-32 |year= 1991 |pmid= 1989880 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Waterman ML, Fischer WH, Jones KA |title=A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. |journal=Genes Dev. |volume=5 |issue= 4 |pages= 656-69 |year= 1991 |pmid= 2010090 |doi=  }}
*{{cite journal  |vauthors=Prieve MG, Guttridge KL, Munguia JE, Waterman ML |title=The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7654–8 |year= 1996 |pmid= 8631802 |doi=10.1074/jbc.271.13.7654 }}
*{{cite journal  | author=Zhou P, Byrne C, Jacobs J, Fuchs E |title=Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 700-13 |year= 1995 |pmid= 7537238 |doi=  }}
*{{cite journal   |vauthors=Behrens J, von Kries JP, Kühl M, etal |title=Functional interaction of beta-catenin with the transcription factor LEF-1 |journal=Nature |volume=382 |issue= 6592 |pages= 638–42 |year= 1996 |pmid= 8757136 |doi= 10.1038/382638a0 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629–39 |year= 1997 |pmid= 9119227 |doi=10.1101/gad.11.5.629  }}
*{{cite journal | author=Prieve MG, Guttridge KL, Munguia JE, Waterman ML |title=The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7654-8 |year= 1996 |pmid= 8631802 |doi= }}
*{{cite journal  |vauthors=Bruhn L, Munnerlyn A, Grosschedl R |title=ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function |journal=Genes Dev. |volume=11 |issue= 5 |pages= 640–53 |year= 1997 |pmid= 9119228 |doi=10.1101/gad.11.5.640 }}
*{{cite journal  | author=Behrens J, von Kries JP, Kühl M, ''et al.'' |title=Functional interaction of beta-catenin with the transcription factor LEF-1. |journal=Nature |volume=382 |issue= 6592 |pages= 638-42 |year= 1996 |pmid= 8757136 |doi= 10.1038/382638a0 }}
*{{cite journal   |vauthors=Brannon M, Gomperts M, Sumoy L, etal |title=A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus |journal=Genes Dev. |volume=11 |issue= 18 |pages= 2359–70 |year= 1997 |pmid= 9308964 |doi=10.1101/gad.11.18.2359  | pmc=316518 }}
*{{cite journal  | author=Bagga R, Emerson BM |title=An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 629-39 |year= 1997 |pmid= 9119227 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Bruhn L, Munnerlyn A, Grosschedl R |title=ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. |journal=Genes Dev. |volume=11 |issue= 5 |pages= 640-53 |year= 1997 |pmid= 9119228 |doi=  }}
*{{cite journal   |vauthors=Korinek V, Barker N, Willert K, etal |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248–56 |year= 1998 |pmid= 9488439 |doi= | pmc=108837 }}
*{{cite journal | author=Brannon M, Gomperts M, Sumoy L, ''et al.'' |title=A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. |journal=Genes Dev. |volume=11 |issue= 18 |pages= 2359-70 |year= 1997 |pmid= 9308964 |doi=  }}
*{{cite journal  |vauthors=Prieve MG, Guttridge KL, Munguia J, Waterman ML |title=Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1 |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4819–32 |year= 1998 |pmid= 9671491 |doi= | pmc=109067 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Levanon D, Goldstein RE, Bernstein Y, etal |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590–5 |year= 1998 |pmid= 9751710 |doi=10.1073/pnas.95.20.11590  | pmc=21685 }}
*{{cite journal  | author=Korinek V, Barker N, Willert K, ''et al.'' |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248-56 |year= 1998 |pmid= 9488439 |doi=  }}
*{{cite journal  |vauthors=Hovanes K, Li TW, Waterman ML |title=The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1994–2003 |year= 2000 |pmid= 10756202 |doi=10.1093/nar/28.9.1994  | pmc=103301  }}
*{{cite journal | author=Prieve MG, Guttridge KL, Munguia J, Waterman ML |title=Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4819-32 |year= 1998 |pmid= 9671491 |doi=  }}
*{{cite journal  |vauthors=Labbé E, Letamendia A, Attisano L |title=Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8358–63 |year= 2000 |pmid= 10890911 |doi= 10.1073/pnas.150152697 | pmc=26952 }}
*{{cite journal  | author=Levanon D, Goldstein RE, Bernstein Y, ''et al.'' |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590-5 |year= 1998 |pmid= 9751710 |doi= }}
*{{cite journal  |vauthors=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=10.1093/nar/29.7.1410 | pmc=31284 }}
*{{cite journal  | author=Hovanes K, Li TW, Waterman ML |title=The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1994-2003 |year= 2000 |pmid= 10756202 |doi=  }}
{{Refend}}
*{{cite journal  | author=Labbé E, Letamendia A, Attisano L |title=Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8358-63 |year= 2000 |pmid= 10890911 |doi= 10.1073/pnas.150152697 }}
*{{cite journal | author=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410-9 |year= 2001 |pmid= 11266540 |doi=  }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|LEF1+protein,+human}}
* {{MeshName|LEF1+protein,+human}}


{{NLM content}}
{{PDB Gallery|geneid=51176}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]

Latest revision as of 12:11, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene.[1]

Function

Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).[2]

Clinical significance

LEF1 is highly overexpressed and associated with disease progression and poor prognosis in B-cell chronic lymphocytic leukemia[3] and other kinds of malignancies like colorectal cancer.[4] It is also a promising potential drug target.[5]

Interactions

Lymphoid enhancer-binding factor 1 has been shown to interact with:

References

  1. ↑ Milatovich A, Travis A, Grosschedl R, Francke U (Mar 1992). "Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf". Genomics. 11 (4): 1040–8. doi:10.1016/0888-7543(91)90030-I. PMID 1783375.
  2. ↑ "Entrez Gene: LEF1 lymphoid enhancer-binding factor 1".
  3. ↑ Erdfelder F, Hertweck M, Filipovich A, Uhrmacher S, Kreuzer KA (2010). "High lymphoid enhancer- binding factor-1 expression is associated with disease progression and poor prognosis in chronic lymphocytic leukemia". Hematology Reports. 2 (1): 3. doi:10.4081/hr.2010.e3.
  4. ↑ Eskandari E, Mahjoubi F, Motalebzadeh J (30 December 2018). "An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers". Gene. 679: 150-159. doi:10.1016/j.gene.2018.09.003. PMID 30193961.
  5. ↑ Gandhirajan RK, Staib PA, Minke K, Gehrke I, Plickert G, Schlösser A, Schmitt EK, Hallek M, Kreuzer KA (April 2010). "Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo". Neoplasia. 12 (4): 326–35. doi:10.1593/neo.91972. PMC 2847740. PMID 20360943.
  6. ↑ Boras K, Hamel PA (January 2002). "Alx4 binding to LEF-1 regulates N-CAM promoter activity". J. Biol. Chem. 277 (2): 1120–7. doi:10.1074/jbc.M109912200. PMID 11696550.
  7. ↑ Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW (January 2000). "A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia". J. Biol. Chem. 275 (1): 651–6. doi:10.1074/jbc.275.1.651. PMID 10617663.
  8. ↑ Edlund S, Lee SY, Grimsby S, Zhang S, Aspenström P, Heldin CH, Landström M (February 2005). "Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis". Mol. Cell. Biol. 25 (4): 1475–88. doi:10.1128/MCB.25.4.1475-1488.2005. PMC 548008. PMID 15684397.
  9. ↑ Grueneberg DA, Pablo L, Hu KQ, August P, Weng Z, Papkoff J (June 2003). "A functional screen in human cells identifies UBF2 as an RNA polymerase II transcription factor that enhances the beta-catenin signaling pathway". Mol. Cell. Biol. 23 (11): 3936–50. doi:10.1128/MCB.23.11.3936-3950.2003. PMC 155208. PMID 12748295.
  10. ↑ Behrens J, von Kries JP, Kühl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W (August 1996). "Functional interaction of beta-catenin with the transcription factor LEF-1". Nature. 382 (6592): 638–42. doi:10.1038/382638a0. PMID 8757136.
  11. ↑ 11.0 11.1 11.2 Labbé E, Letamendia A, Attisano L (July 2000). "Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8358–63. doi:10.1073/pnas.150152697. PMC 26952. PMID 10890911.
  12. ↑ Hecht A, Stemmler MP (February 2003). "Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4". J. Biol. Chem. 278 (6): 3776–85. doi:10.1074/jbc.M210081200. PMID 12446687.
  13. ↑ Yasumoto K, Takeda K, Saito H, Watanabe K, Takahashi K, Shibahara S (June 2002). "Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling". EMBO J. 21 (11): 2703–14. doi:10.1093/emboj/21.11.2703. PMC 126018. PMID 12032083.
  14. ↑ Sachdev S, Bruhn L, Sieber H, Pichler A, Melchior F, Grosschedl R (December 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. 15 (23): 3088–103. doi:10.1101/gad.944801. PMC 312834. PMID 11731474.

Further reading

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