Listeriosis medical therapy

Revision as of 22:31, 29 July 2020 by WikiBot (talk | contribs) (Bot: Removing from Primary care)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Listeriosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Listeriosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Screening

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

MRI

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Listeriosis medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Listeriosis medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Listeriosis medical therapy

CDC on Listeriosis medical therapy

Listeriosis medical therapy in the news

Blogs on Listeriosis medical therapy

Directions to Hospitals Treating Listeriosis

Risk calculators and risk factors for Listeriosis medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

All patients with listeriosis require antibiotic therapy. Ampicillin, with or without gentamicin, is the antibiotic of choice for the treatment of listeriosis. Patients intolerant to penicillins may be managed with trimethoprim-sulfamethoxazole. Duration of therapy depends on the clinical syndrome and may range from several days in non-complicated gastroenteritis to 6 weeks in endocarditis or encephalitis. Listerial gastroenteritis is frequently self-limited among healthy adults, but a short course of oral ampicillin may be considered among immunocompromised or pregnant individuals or those who have ingested food implicated in outbreaks. Non-gastroenteritis listeriosis often require hospitalization and intravenous (IV) antibiotic therapy.

Medical Therapy

  • The table below describes the recommended duration of therapy based upon the clinical syndrome:[2][3]
Listeriosis Clinical Syndrome Duration of Antibiotic Therapy
Gastroenteritis, if indicated Several days
Listeriosis in pregnancy 2 weeks
Listeriosis in neonates 2 weeks
Meningitis 2–3 weeks
Bacteremia 2–4 weeks
Endocarditis 4–6 weeks
Non-CNS listeriosis in immunocompromised hosts 4–6 weeks
Brain abscess or rhombencephalitis 6 weeks

Antimicrobial Regimen

  • 1. Meningitis [4]
  • Preferred regimen: Ampicillin 2g IV q4-6h ± Gentamicin 1.7 mg/kg IV q8h for more than 3 weeks
  • Alternative regimen: TMP-SMX 3-5 mg/kg (trimethoprim) IV q6h for more than 3 weeks
  • 2. Bacteremia
  • Preferred regimen: Ampicillin 2g IV q4-6h ± Gentamicin 1.7 mg/kg IV q8h for 2 weeks
  • Alternative regimen: TMP-SMX 3-5 mg/kg (trimethoprim) q6h IV for 2 weeks
  • 3. Brain abscess or rhomboencephalitis
  • Preferred regimen: Ampicillin 2g IV q4-6h ± Gentamicin 1.7 mg/kg IV q8h for 4-6 weeks
  • Alternative regimen: TMP-SMX 3-5 mg/kg (trimethoprim) q6h IV for 4-6 weeks
  • 4. Gastroenteritis
  • Preferred regimen (1): Amoxicillin 2g IV q4-6h
  • Preferred regimen (2): TMP-SMX 3-5 mg/kg (trimethoprim) q6h IV for 7 days

References

  1. Gellin, B. G. (1989-03-03). "Listeriosis". JAMA: the journal of the American Medical Association. 261 (9): 1313–1320. ISSN 0098-7484. PMID 2492614. Unknown parameter |coauthors= ignored (help)
  2. Lorber, B. (1997-01). "Listeriosis". Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 24 (1): 1–9, quiz 10-11. ISSN 1058-4838. PMID 8994747. Check date values in: |date= (help)
  3. Gellin, B. G. (1989-03-03). "Listeriosis". JAMA: the journal of the American Medical Association. 261 (9): 1313–1320. ISSN 0098-7484. PMID 2492614. Unknown parameter |coauthors= ignored (help)
  4. Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.

Template:WH Template:WS