Liquefactive necrosis

Revision as of 16:55, 9 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Liquefactive necrosis
This is a low-power photomicrograph of lung tissue containing a large abscess. The center of the abscess contains necrotic debris (1) and there is a rim of viable inflammatory cells (arrows) surrounding this abscess.
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

WikiDoc Resources for Liquefactive necrosis

Articles

Most recent articles on Liquefactive necrosis

Most cited articles on Liquefactive necrosis

Review articles on Liquefactive necrosis

Articles on Liquefactive necrosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Liquefactive necrosis

Images of Liquefactive necrosis

Photos of Liquefactive necrosis

Podcasts & MP3s on Liquefactive necrosis

Videos on Liquefactive necrosis

Evidence Based Medicine

Cochrane Collaboration on Liquefactive necrosis

Bandolier on Liquefactive necrosis

TRIP on Liquefactive necrosis

Clinical Trials

Ongoing Trials on Liquefactive necrosis at Clinical Trials.gov

Trial results on Liquefactive necrosis

Clinical Trials on Liquefactive necrosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Liquefactive necrosis

NICE Guidance on Liquefactive necrosis

NHS PRODIGY Guidance

FDA on Liquefactive necrosis

CDC on Liquefactive necrosis

Books

Books on Liquefactive necrosis

News

Liquefactive necrosis in the news

Be alerted to news on Liquefactive necrosis

News trends on Liquefactive necrosis

Commentary

Blogs on Liquefactive necrosis

Definitions

Definitions of Liquefactive necrosis

Patient Resources / Community

Patient resources on Liquefactive necrosis

Discussion groups on Liquefactive necrosis

Patient Handouts on Liquefactive necrosis

Directions to Hospitals Treating Liquefactive necrosis

Risk calculators and risk factors for Liquefactive necrosis

Healthcare Provider Resources

Symptoms of Liquefactive necrosis

Causes & Risk Factors for Liquefactive necrosis

Diagnostic studies for Liquefactive necrosis

Treatment of Liquefactive necrosis

Continuing Medical Education (CME)

CME Programs on Liquefactive necrosis

International

Liquefactive necrosis en Espanol

Liquefactive necrosis en Francais

Business

Liquefactive necrosis in the Marketplace

Patents on Liquefactive necrosis

Experimental / Informatics

List of terms related to Liquefactive necrosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Liquefactive necrosis (or colliquative necrosis) is a type of necrosis which is characteristic of focal bacterial or fungal infections. In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes, resulting in a soft, circumscribed lesion consisting of pus and the fluid remains of necrotic tissue. After the removal of cell debris by white blood cells, a fluid filled space is left. It is generally associated with abscess formation and is commonly found in the central nervous system.

For unclear reasons, hypoxic death of cells within the central nervous system also results in liquefactive necrosis.(Brain Infarction => Emollition) This is a process in which lysosomes turn tissues into soup as a result of lysosomal release of digestive enzymes in the face of bacterial onslaught. Loss of tissue architecture means that the tissue is essentially liquefied.

Pathological Findings: Case #1: Lung: Liquefactive necrosis

Clinical Summary

A 67-year-old male with advanced colon cancer developed obstruction of the bowel and underwent palliative surgery to remove an 8-cm portion of colon containing the obstruction. During the surgery the patient had several episodes of hypotension. After surgery he did not regain consciousness and required ventilator support. Four days after surgery, the patient developed a fever and his white blood cell count was found to be 15,256 cells/cmm. Thus, he was started on broad-spectrum antibiotics. A chest x-ray demonstrated infiltrates in both lungs, which worsened over the next several days. His overall condition continued to deteriorate and he died 12 days after surgery.

Autopsy Findings

At autopsy, metastatic colon cancer was found throughout the abdominal cavity and invading into the liver. The lungs were markedly consolidated and had several focal abscesses that were 2 to 4 cm in diameter. Liquefied material poured out from inside these abscesses when the lungs were sliced.

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology




Template:Pathology Template:WH Template:WS