Liposarcoma pathophysiology: Difference between revisions

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Occurs most frequently at the retroperitoneum and paratesticular regions.  The particular [[histological]] finding in this type of well differentiated liposarcoma is the identification of distinctive [[stromal]] cells distributed across the tissue, and associated with lipoblasts filled with multiple [[vacuoles]].  This association forms a [[collagenous]] background of fibrillary appearance.  In certain cases the fibrous component of the [[neoplasm]] may occupy most of its mass.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
Occurs most frequently at the retroperitoneum and paratesticular regions.  The particular [[histological]] finding in this type of well differentiated liposarcoma is the identification of distinctive [[stromal]] cells distributed across the tissue, and associated with lipoblasts filled with multiple [[vacuoles]].  This association forms a [[collagenous]] background of fibrillary appearance.  In certain cases the fibrous component of the [[neoplasm]] may occupy most of its mass.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
====Adipocytic Liposarcoma====
====Adipocytic Liposarcoma====
Frequently composed by [[adipocytes]] with different cell sizes, hyperchromasia and nuclear atypia.  [[Fibrous]] septa may be identified among [[adipocytes]], containing hyperchromatic [[stromal cells]].  
Frequently composed by [[adipocytes]] with different cell sizes, hyperchromasia and nuclear atypia.  [[Fibrous]] septa may be identified among [[adipocytes]], containing hyperchromatic [[stromal cells]]. Besides these two types of cells, mono or multivacuolated lipoblasts may also be identified.  These last are characterized by the presence of single (mono) or multiple (multi) peripheral cytoplasmic vacuoles that press on the hyperchromatic nucleus.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>


In general, [[adipocytic]] [[neoplasms]] are often identified by the presence of these lipoblasts.<ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>





Revision as of 15:50, 19 September 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Pathogenesis

According to their class, each liposarcoma will have specific characteristics and pathogenesis:

Well Differentiated Liposarcoma

This type of liposarcoma occurs both at the limbs and retroperitoneum in equal frequency, and occasionally at the mediastinum and spermatic cord, representing about 45% of liposarcomas.[1]

According to the WHO classification described previously, well differentiated liposarcomas may be sub-classified into 3 types: sclerosing; adipocytic; and inflammatory.

Sclerosing Liposarcoma

Occurs most frequently at the retroperitoneum and paratesticular regions. The particular histological finding in this type of well differentiated liposarcoma is the identification of distinctive stromal cells distributed across the tissue, and associated with lipoblasts filled with multiple vacuoles. This association forms a collagenous background of fibrillary appearance. In certain cases the fibrous component of the neoplasm may occupy most of its mass.[1]

Adipocytic Liposarcoma

Frequently composed by adipocytes with different cell sizes, hyperchromasia and nuclear atypia. Fibrous septa may be identified among adipocytes, containing hyperchromatic stromal cells. Besides these two types of cells, mono or multivacuolated lipoblasts may also be identified. These last are characterized by the presence of single (mono) or multiple (multi) peripheral cytoplasmic vacuoles that press on the hyperchromatic nucleus.[1]


In general, adipocytic neoplasms are often identified by the presence of these lipoblasts.[1]


Inflammatory Liposarcoma

Dedifferentiated Liposarcoma

Myxoid Liposarcoma

Round Cell Liposarcoma

Pleomorphic Liposarcoma

Genetics

Associated Conditions

Gross Pathology

Microscopic Pathology

References

  1. 1.0 1.1 1.2 1.3 Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.


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