Liposarcoma CT: Difference between revisions

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==Overview==
==Overview==
CT imaging is one of the most important tests for the diagnosis of liposarcoma. CT should assess the size, location and depth of the liposarcoma, as well as the lymph node involvement and distant metastasis.  CT findings can be correlated with the histopathological subtype.
CT imaging is crucial for the diagnosis of liposarcoma. CT scan may detect regions of lipid and non-lipid components that correlate with histological subtypes of liposarcoma. CT imaging may demonstrate the size, location, and depth of a liposarcoma, as well as [[lymph node]] involvement and distant [[metastasis]].  CT findings may be correlated with the [[histopathological]] subtype.


==CT Scan==
==CT Scan==
* The appearance and morphologic relationship in the CT imaging of lipid and non-lipid components frequently allows the identification of the specific histologic subtype of liposarcoma.<ref name="KimMurakami1996">{{cite journal|last1=Kim|first1=T|last2=Murakami|first2=T|last3=Oi|first3=H|last4=Tsuda|first4=K|last5=Matsushita|first5=M|last6=Tomoda|first6=K|last7=Fukuda|first7=H|last8=Nakamura|first8=H|title=CT and MR imaging of abdominal liposarcoma.|journal=American Journal of Roentgenology|volume=166|issue=4|year=1996|pages=829–833|issn=0361-803X|doi=10.2214/ajr.166.4.8610559}}</ref>
* A CT image commonly detects areas of focal or diffuse infiltration of lipid and non-lipid components.
* A CT image commonly detects focal or diffuse areas of lipid and non-lipid components.
 
* CT scan is also used to determine the stage of the disease assessing the presence of lymph nodes and distant metastasis.<ref name="KumarasamyGayer2011">{{cite journal|last1=Kumarasamy|first1=Narmadan A.|last2=Gayer|first2=Gabriela|title=Retroperitoneal Sarcomas|journal=Seminars in Ultrasound, CT and MRI|volume=32|issue=5|year=2011|pages=422–432|issn=08872171|doi=10.1053/j.sult.2011.06.002}}</ref>
* The appearance and morphologic relationship between the lipid and non-lipid components of a liposarcoma on CT scan frequently help in identifying the specific histologic subtype of liposarcoma.<ref name="KimMurakami1996">{{cite journal|last1=Kim|first1=T|last2=Murakami|first2=T|last3=Oi|first3=H|last4=Tsuda|first4=K|last5=Matsushita|first5=M|last6=Tomoda|first6=K|last7=Fukuda|first7=H|last8=Nakamura|first8=H|title=CT and MR imaging of abdominal liposarcoma.|journal=American Journal of Roentgenology|volume=166|issue=4|year=1996|pages=829–833|issn=0361-803X|doi=10.2214/ajr.166.4.8610559}}</ref>
* CT scan also determines the size and depth of the tumor, stage of the disease, presence of lymphadenopathy, and evidence of distal metastasis.<ref name="KumarasamyGayer2011">{{cite journal|last1=Kumarasamy|first1=Narmadan A.|last2=Gayer|first2=Gabriela|title=Retroperitoneal Sarcomas|journal=Seminars in Ultrasound, CT and MRI|volume=32|issue=5|year=2011|pages=422–432|issn=08872171|doi=10.1053/j.sult.2011.06.002}}</ref>


====CT Findings According to the Liposarcoma Subtype====
====CT Findings According to the Liposarcoma Subtype====
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| style="padding: 5px 5px; background: #F5F5F5;" colspan=7|<small> Table adapted from CT Manifestations in Histologic Subtypes of Retroperitoneal Liposarcoma<ref>{{Cite journal
| style="padding: 5px 5px; background: #F5F5F5;" colspan=7|<small> Table adapted from Lu J, Qin Q, Zhan LL, et al. Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma. ''Asian Pac J Cancer Prev''. 2014;15(15):6041-6.<ref>{{Cite journal
| author = [[Jing Lu]], [[Qin Qin]], [[Liang-Liang Zhan]], [[Xi Yang]], [[Qing Xu]], [[Jing Yu]], [[Li-Na Dou]], [[Hao Zhang]], [[Yan Yang]], [[Xiao-Chen Chen]], [[Yue-Hua Yang]], [[Hong-Yan Cheng]] & [[Xin-Chen Sun]]
| author = [[Jing Lu]], [[Qin Qin]], [[Liang-Liang Zhan]], [[Xi Yang]], [[Qing Xu]], [[Jing Yu]], [[Li-Na Dou]], [[Hao Zhang]], [[Yan Yang]], [[Xiao-Chen Chen]], [[Yue-Hua Yang]], [[Hong-Yan Cheng]] & [[Xin-Chen Sun]]
  | title = Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma
  | title = Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma
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  | pmid = 25124571
  | pmid = 25124571
}}</ref> </small>
}}</ref> </small>
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|[[Image:Liposarcoma 02.jpg|thumb|300px]]
|[[Image:Liposarcoma-001.jpg|thumb|300px]]
|[[Image:Liposarcoma-003.jpg|thumb|300px]]
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|[[Image:Liposarcoma-004.jpg|thumb|300px]]
|[[Image:Liposarcoma-005.jpg|thumb|300px]]
|[[Image:Myxoid-liposarcoma -001.jpg|thumb|300px]]
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{|
[[Image:Myxoid-liposarcoma -002.jpg|thumb||left|300px]]
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Latest revision as of 16:53, 27 May 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Overview

CT imaging is crucial for the diagnosis of liposarcoma. CT scan may detect regions of lipid and non-lipid components that correlate with histological subtypes of liposarcoma. CT imaging may demonstrate the size, location, and depth of a liposarcoma, as well as lymph node involvement and distant metastasis. CT findings may be correlated with the histopathological subtype.

CT Scan

  • A CT image commonly detects areas of focal or diffuse infiltration of lipid and non-lipid components.
  • The appearance and morphologic relationship between the lipid and non-lipid components of a liposarcoma on CT scan frequently help in identifying the specific histologic subtype of liposarcoma.[1]
  • CT scan also determines the size and depth of the tumor, stage of the disease, presence of lymphadenopathy, and evidence of distal metastasis.[2]

CT Findings According to the Liposarcoma Subtype

Subtypes Density Margins Fat Content Nodular muscle-density area in tumor Calcifications Necrotic or cystic areas
Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) Fat Smooth regular > 65% ++ Few/none +
Dedifferentiated liposarcoma (DDL) Mixed Rough irregular 30-60% +++ Few/none ++
Myxoid/round cell liposarcoma (ML/RCL) Mixed Rough irregular 25-50% + Common +++
Pleomorphic liposarcoma (PL) Soft tissue Incomplete irregular 6-25% + Few/none +
Mixed-type liposarcoma Mixed Smooth regular 30-60% ++ Common +
Table adapted from Lu J, Qin Q, Zhan LL, et al. Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma. Asian Pac J Cancer Prev. 2014;15(15):6041-6.[3]

References

  1. Kim, T; Murakami, T; Oi, H; Tsuda, K; Matsushita, M; Tomoda, K; Fukuda, H; Nakamura, H (1996). "CT and MR imaging of abdominal liposarcoma". American Journal of Roentgenology. 166 (4): 829–833. doi:10.2214/ajr.166.4.8610559. ISSN 0361-803X.
  2. Kumarasamy, Narmadan A.; Gayer, Gabriela (2011). "Retroperitoneal Sarcomas". Seminars in Ultrasound, CT and MRI. 32 (5): 422–432. doi:10.1053/j.sult.2011.06.002. ISSN 0887-2171.
  3. Jing Lu, Qin Qin, Liang-Liang Zhan, Xi Yang, Qing Xu, Jing Yu, Li-Na Dou, Hao Zhang, Yan Yang, Xiao-Chen Chen, Yue-Hua Yang, Hong-Yan Cheng & Xin-Chen Sun (2014). "Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma". Asian Pacific journal of cancer prevention : APJCP. 15 (15): 6041–6046. PMID 25124571.


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