General overdose information
Levofloxacin exhibits a low potential for acute toxicity. Mice, rats, dogs and monkeys exhibited
the following clinical signs after receiving a single high dose of levofloxacin: ataxia, ptosis,
decreased locomotor activity, dyspnea, prostration, tremors, and convulsions. Doses in excess of
1500 mg/kg orally and 250 mg/kg i.v. produced significant mortality in rodents. Return to top
In the event of an acute overdosage, the stomach should be emptied. The patient should be observed and appropriate hydration maintained. Levofloxacin is not efficiently removed by hemodialysis or
peritoneal dialysis. Return to top
Adapted from the FDA Package Insert.