Levocabastine

Levocabastine
Clinical data
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	Ophthalmic, intranasal
ATC code	R01AC02 (WHO) S01GX02 (WHO);
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	3
Identifiers
	IUPAC name 1-[4-cyano-4-(4-fluorophenyl)-cyclohexyl]- 3-methyl-4-phenyl-piperidine-4- carboxylic acid;
CAS Number	79516-68-0;
PubChem CID	54385;
DrugBank	APRD01069;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C26H29FN2O2
Molar mass	420.519 g/mol

Levocabastine is a selective second-generation H₁-receptor antagonist used for allergic conjunctivitis.

Levocabastine was discovered at Janssen Pharmaceutica in 1979.

References

Pipkorn U, Bende M, Hedner J, Hedner T., A double-blind evaluation of topical levocabastine, a new specific H1 antagonist in patients with allergic conjunctivitis, Allergy. 1985 Oct;40(7):491-6.
RxList (2004). "Livostin Online, Description, Chemistry, Ingredients - Levocabastine". LIVOSTIN. RxList Inc. Retrieved 9 October. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)
Novartis Pharmaceuticals (2002). "LIVOSTIN^®" (PDF). Unknown parameter |month= ignored (help); Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Unknown parameter |accessmonthday= ignored (help)

^ "RxMed: Pharmaceutical Information - LIVOSTIN NASAL SPRAY". Retrieved 13 November. Unknown parameter |accessyear= ignored (|access-date= suggested) (help); Check date values in: |accessdate= (help)

v t e Decongestants and other nasal preparations (R01)
Topical: sympathomimetics, plain	Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine
Topical: antiallergic agents, excluding corticosteroids	Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine
Topical: corticosteroids	Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone - Ciclesonide
Topical: other nasal preparations	Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin
Systemic use: Sympathomimetics	Phenylpropanolamine - Pseudoephedrine - Phenylephrine

Clinical data

Pregnancy category	AU: B3 US: C (Risk not ruled out)
Routes of administration	Ophthalmic, intranasal^[1]
ATC code	R01AC02 (WHO) S01GX02 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life	3
Identifiers
IUPAC name 1-[4-cyano-4-(4-fluorophenyl)-cyclohexyl]- 3-methyl-4-phenyl-piperidine-4- carboxylic acid
CAS Number	79516-68-0
PubChem CID	54385
DrugBank	APRD01069
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₆H₂₉FN₂O₂
Molar mass	420.519 g/mol