Levo-transposition of the great arteries pathophysiology: Difference between revisions
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{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh@perfuse.org]; {{CZ}}; [[User:KeriShafer|Keri Shafer, M.D.]] [mailto:kshafer@bidmc.harvard.edu]; '''Assistant Editor(s)-In-Chief:''' [[Kristin Feeney|Kristin Feeney, B.S.]] [mailto:kfeeney@perfuse.org] | |||
==Overview== | |||
===Pathophysiology=== | ===Pathophysiology=== | ||
Levo-transposition of the great arteries is a defect in which [[atrial]] and ventricular morphologies are discordant, and also the morphology of each ventricle is discordant with the great artery that comes from it. In other words this anomaly is a "double discordance" with both atrioventricular and ventriculoarterial discordance, which essentially "corrects" the physiologic abnormality. The atria are in normal position and received appropriate venous return, but the atria are connected to the opposite ventricle ([[RA]] to the [[LV]] and [[LA]] to the [[RV]]). In addition the ventricles are inversely connected to the wrong great artery. | Levo-transposition of the great arteries is a defect in which [[atrial]] and ventricular morphologies are discordant, and also the morphology of each ventricle is discordant with the great artery that comes from it. In other words this anomaly is a "double discordance" with both atrioventricular and ventriculoarterial discordance, which essentially "corrects" the physiologic abnormality. The atria are in normal position and received appropriate venous return, but the atria are connected to the opposite ventricle ([[RA]] to the [[LV]] and [[LA]] to the [[RV]]). In addition the ventricles are inversely connected to the wrong great artery. | ||
Revision as of 14:59, 12 August 2011
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Levo-transposition of the great arteries Microchapters | |
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Differentiating Levo-transposition of the great arteries from other Diseases | |
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Treatment | |
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Levo-transposition of the great arteries pathophysiology On the Web | |
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American Roentgen Ray Society Images of Levo-transposition of the great arteries pathophysiology | |
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FDA on Levo-transposition of the great arteries pathophysiology | |
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CDC on Levo-transposition of the great arteries pathophysiology | |
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Levo-transposition of the great arteries pathophysiology in the news | |
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Blogs on Levo-transposition of the great arteries pathophysiology | |
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Risk calculators and risk factors for Levo-transposition of the great arteries pathophysiology | |
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Transposition of the great vessels Microchapters |
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Classification |
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Differentiating Transposition of the great vessels from other Diseases |
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Diagnosis |
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Treatment |
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Surgery |
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Case Studies |
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Levo-transposition of the great arteries pathophysiology On the Web |
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American Roentgen Ray Society Images of Levo-transposition of the great arteries pathophysiology |
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FDA on Levo-transposition of the great arteries pathophysiology |
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CDC on Levo-transposition of the great arteries pathophysiology |
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Levo-transposition of the great arteries pathophysiology in the news |
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Blogs on Levo-transposition of the great arteries pathophysiology |
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Risk calculators and risk factors for Levo-transposition of the great arteries pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]
Overview
Pathophysiology
Levo-transposition of the great arteries is a defect in which atrial and ventricular morphologies are discordant, and also the morphology of each ventricle is discordant with the great artery that comes from it. In other words this anomaly is a "double discordance" with both atrioventricular and ventriculoarterial discordance, which essentially "corrects" the physiologic abnormality. The atria are in normal position and received appropriate venous return, but the atria are connected to the opposite ventricle (RA to the LV and LA to the RV). In addition the ventricles are inversely connected to the wrong great artery.
In a normal heart, oxygen-depleted ("blue") blood is pumped from the right atrium into the right ventricle, then through the pulmonary artery to the lungs where it is oxygenated. The oxygen-rich ("red") blood then returns, via the pulmonary veins, to the left atrium from which it is pumped into the left ventricle, then through the aorta to the rest of the body, including the heart muscle itself.
With l-TGA, blue blood is pumped from the right atrium into the morphological left ventricle (which lies on the right side of the heart), then through the pulmonary artery to the lungs. The red blood then returns, via the pulmonary veins, to the left atrium from which it is pumped into the morphological right ventricle, then ejected into the aorta.
References
Acknowledgements and Initial Contributors to Page
Leida Perez, M.D.
External links
- Diagram at kumc.edu
- Diagram and description at umich.edu
- Overview at pediheart.org
- Royal Children's Hospital, Melbourne
- Mayo Clinic, Arizona - Florida - Minnesota, USA
