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=====Clinical manifestations=====
=====Clinical manifestations=====
* [[Adult respiratory distress syndrome]]
* [[Adult respiratory distress syndrome]]
* [[Bronchial breath sounds]]
* [[Breath sounds|Bronchial breath sounds]]
* [[Dry cough]]
* [[Dry cough]]
* [[High grade fever]]
* [[Fever|High grade fever]]
* [[Progressive dyspnea]]
* [[Dyspnea|Progressive dyspnea]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
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=====Radiographic features=====
=====Radiographic features=====
* [[Alveolar consolidation]] on chest radiograph
* [[Alveoli|Alveolar consolidation]] on chest radiograph
* [[Lobar consolidation]] on chest radiograph
* [[Consolidation (medicine)|Lobar consolidation]] on chest radiograph


----
----
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=====Clinical manifestations=====
=====Clinical manifestations=====
* Dry cough
* [[Dry cough]]
* Progressive dyspnea
* [[Dyspnea|Progressive dyspnea]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
Line 49: Line 49:
=====Radiographic features=====
=====Radiographic features=====
* Disseminated consolidation on chest radiograph
* Disseminated consolidation on chest radiograph
* [[Interstitial infiltrate]] on chest radiograph
* Interstitial infiltrate on chest radiograph
* Increased uptake on gallium scan
* Increased uptake on gallium scan


Line 57: Line 57:


=====Clinical manifestations=====
=====Clinical manifestations=====
* Dry cough
* [[Dry cough]]
* Pleuritic chest pain
* [[Pleuritic chest pain]]
* Bronchial breath sounds
* Bronchial [[breath sounds]]
* Inflammed, opaque, hypomobile tympanic membrane
* Inflamed, opaque, hypomobile [[tympanic membrane]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
* Lymphocytosis
* [[Lymphocytosis]]
* Cold agglutinins positive
* [[Cold agglutinins]] positive


=====Radiographic features=====
=====Radiographic features=====
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=====Clinical manifestations=====
=====Clinical manifestations=====
* High grade fever
* [[Fever|High grade fever]]
* Hemoptysis
* [[Hemoptysis]]
* Fine rales
* [[Rales|Fine rales]]
* Pleuritic chest pain
* [[Pleuritic chest pain]]
* Increased breath sounds
* Increased [[breath sounds]]
* Bronchial breath sounds
* Bronchial b[[Breath sounds|reath sounds]]
* Dullness on chest percussion
* Dullness on chest percussion
* Purulent sputum
* [[Sputum|Purulent sputum]]
* Shallow respiration
* [[Shallow respiration]]
* Pectoriloquy
* Pectoriloquy
* Increased tactile fremitus
* Increased [[tactile fremitus]]
* Productive cough
* [[Productive cough]]
* Egophony
* [[Egophony]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
Line 108: Line 108:
=====Clinical manifestations=====
=====Clinical manifestations=====
* Immunosuppressive state
* Immunosuppressive state
* Subcutaneous emphysema
* Subcutaneous [[emphysema]]
* Hacking cough
* [[Cough|Hacking cough]]
* Progressive dyspnea
* [[Dyspnea|Progressive dyspnea]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
* Respiratory alkalosis
* [[Respiratory alkalosis]]
* Serum beta-D-glucan elevation
* Serum beta-D-glucan elevation


Line 128: Line 128:
=====Clinical manifestations=====
=====Clinical manifestations=====
* Calf pain or swelling
* Calf pain or swelling
* Decreased pulse pressure
* Decreased [[pulse pressure]]
* Dyspnea
* [[Dyspnea]]
* Hemoptysis
* [[Hemoptysis]]
* Hyperventilation
* Hyperventilation
* Immobility
* [[Immobility]]
* Increased pulmonic component of heart sound
* Increased pulmonic component of heart sound
* Pleuritic chest pain
* [[Pleuritic chest pain]]
* Prior DVT
* Prior [[Deep vein thrombosis|DVT]]
* Pulmonary hypertension
* [[Pulmonary hypertension]]
* Right ventricular heave
* Right ventricular heave
* Right-to-left shunt
* [[Right-to-left shunt]]
* Substernal chest pain
* [[Substernal chest pain]]
* Tachypnea
* [[Tachypnea]]
* Thrombophlebitis
* [[Thrombophlebitis]]
* Venous stasis
* [[Venous stasis]]
* Bone fracture
* [[Bone fracture]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
* D-dimer elevation
* [[D-dimer]] elevation
* Hypocapnia
* [[Hypocapnia]]
* Hypoxia
* [[Hypoxia]]
* Pleural effusion (exudative or bloody)
* [[Pleural effusion]] (exudative or bloody)
* Atrial fibrillation on ECG
* [[Atrial fibrillation]] on ECG
* Right axis deviation on ECG
* [[Right axis deviation]] on ECG
* Right ventricular overload on ECG
* Right ventricular overload on ECG


Line 158: Line 158:
* Atelectasis on chest radiograph
* Atelectasis on chest radiograph
* Lobar consolidation on chest radiograph
* Lobar consolidation on chest radiograph
* Prominent pulmonary artery on chest radiograph
* Prominent [[pulmonary artery]] on chest radiograph
* Hampton's hump on chest radiograph
* [[Hampton's hump]] on chest radiograph
* Right ventricular enlargement on echocardiography
* Right ventricular enlargement on echocardiography
* Thrombus on echocardiography
* [[Thrombus]] on echocardiography
* Segmental perfusion defect on lung scan
* Segmental perfusion defect on lung scan
* V/Q mismatch on lung scan
* V/Q mismatch on lung scan
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=====Clinical manifestations=====
=====Clinical manifestations=====
* Pectoriloquy
* Pectoriloquy
* Bronchial breath sounds
* Bronchial [[breath sounds]]
* Erythema nodosum
* [[Erythema nodosum]]
* Purulent sputum
* Purulent [[sputum]]
* Shallow respiration
* [[Shallow respiration]]
* Increased tactile fremitus
* Increased [[tactile fremitus]]
* Pleuritic chest pain
* [[Pleuritic chest pain]]
* Egophony
* [[Egophony]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
* Gram-positive cocci in chains on sputum Gram stain
* [[Gram-positive cocci]] in chains on sputum [[Gram stain]]
* Respiratory alkalosis
* [[Respiratory alkalosis]]
* Pleural effusion (exudative)
* [[Pleural effusion]] (exudative)


=====Radiographic features=====
=====Radiographic features=====
* Alveolar consolidation on chest radiograph
* Alveolar consolidation on chest radiograph
* Lobar consolidation on chest radiograph
* Lobar consolidation on chest radiograph
* Empyema on chest radiograph
* [[Empyema]] on chest radiograph
* Increased uptake on gallium scan
* Increased uptake on [[gallium scan]]


----
----
Line 195: Line 195:


=====Clinical manifestations=====
=====Clinical manifestations=====
* Pleuritic chest pain
* [[Pleuritic chest pain]]
* Bronchial breath sounds
* [[Breath sounds|Bronchial breath sounds]]
* Recent influenza
* Recent [[influenza]]
* Fine rales
* Fine [[rales]]
* Bronchovesicular breath sounds
* [[Breath sounds|Bronchovesicular breath sounds]]


=====Laboratory abnormalities=====
=====Laboratory abnormalities=====
* Lymphocytosis
* [[Lymphocytosis]]
* Respiratory alkalosis
* [[Respiratory alkalosis]]


=====Radiographic features=====
=====Radiographic features=====

Revision as of 16:59, 13 June 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Legionellosis must be differentiated from other causes of fever, dyspnea, cough, and sputum production, such as bacterial pnuemonia, viral pneumonia, and other causes of atypical pneumonia.

Differential Diagnosis

The following conditions must be considered in the differential diagnosis of Legionnaires' disease: DDx [1][2][3][4][5][6][7]


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Mahshid Mir, M.D. [3]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Mahshid Mir, M.D. [5]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
  • Nonspecific
Radiographic features
  • Disseminated consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph
  • Increased uptake on gallium scan


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [6] Mahshid Mir, M.D. [7]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features
  • Alveolar consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph
  • Lobar consolidation on chest radiograph


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [8] Mahshid Mir, M.D. [9]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
  • Gram positive diplococci on sputum Gram stain
  • Pleural effusion (exudative)
  • Respiratory alkalosis
Radiographic features
  • Parenchymal hyperlucency on chest radiograph
  • Increased uptake on gallium scan
  • Unilateral diaphragm elevation on chest radiograph
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [10] Mahshid Mir, M.D. [11]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph
  • Pneumomediastinum on chest radiograph


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [12] Mahshid Mir, M.D. [13]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features
  • Normal chest radiograph
  • Atelectasis on chest radiograph
  • Lobar consolidation on chest radiograph
  • Prominent pulmonary artery on chest radiograph
  • Hampton's hump on chest radiograph
  • Right ventricular enlargement on echocardiography
  • Thrombus on echocardiography
  • Segmental perfusion defect on lung scan
  • V/Q mismatch on lung scan


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [14] Mahshid Mir, M.D. [15]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features
  • Alveolar consolidation on chest radiograph
  • Lobar consolidation on chest radiograph
  • Empyema on chest radiograph
  • Increased uptake on gallium scan


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [16] Mahshid Mir, M.D. [17]

Differential Diagnosis
DDx Alphabetic Order
A B
C D
E F
G H
I J
K L
M N
O P
Q R
S T
U V
W X
Y Z


Template:WikiDoc Sources

Clinical manifestations
Laboratory abnormalities
Radiographic features
  • Lobar consolidation on chest radiograph
  • Interstitial infiltrate on chest radiograph

References

  1. Ferri, Fred (2011). Ferri's differential diagnosis: a practical guide to the differential diagnosis of symptoms, signs, and clinical disorders. Philadelphia, PA: Elsevier/Mosby. ISBN 978-0323076999.
  2. Siegenthaler, Walter (2007). Differential diagnosis in internal medicine: from symptom to diagnosis. Stuttgart New York: Thieme. ISBN 978-1588905512.
  3. Mesko, Dusan (2002). Differential diagnosis by laboratory medicine: a quick reference for physicians. Berlin New York: Springer-Verlag. ISBN 978-3540430575.
  4. Reeder and Felson's gamuts in radiology: comprehensive lists of roentgen differential diagnosis. Place of publication not identified: Springer. 2014. ISBN 978-1475781229.
  5. Burgener, Francis (2008). Differential diagnosis in conventional radiology. Stuttgart New York: Thieme. ISBN 978-1588902757.
  6. Gattuso, Paolo (2015). Differential diagnosis in surgical pathology. Philadelphia, PA: Saunders/Elsevier. ISBN 978-1455770137.
  7. "DXplain".