LTBP2

Latent transforming growth factor beta binding protein 2
Identifiers
Symbols	LTBP2 ; C14orf141; LTBP3; MSTP031
External IDs	Template:OMIM5 Template:MGI HomoloGene: 369
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LTBP2 204682 at tn.png
File:PBB GE LTBP2 gnf1h00588 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Latent transforming growth factor beta binding protein 2, also known as LTBP2, is a human gene.

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

Further reading

• Chambaz EM, Souchelnitskiy S, Pellerin S; et al. (1996). "Transforming growth factors-beta s: a multifunctional cytokine family. Implication in the regulation of adrenocortical cell endocrine functions". Horm. Res. 45 (3–5): 222–6. PMID 8964588.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Munger JS, Harpel JG, Gleizes PE; et al. (1997). "Latent transforming growth factor-beta: structural features and mechanisms of activation". Kidney Int. 51 (5): 1376–82. PMID 9150447.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taipale J, Saharinen J, Keski-Oja J (1998). "Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion". Adv. Cancer Res. 75: 87–134. PMID 9709808.CS1 maint: Multiple names: authors list (link)
• Saharinen J, Hyytiäinen M, Taipale J, Keski-Oja J (2000). "Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action". Cytokine Growth Factor Rev. 10 (2): 99–117. PMID 10743502.CS1 maint: Multiple names: authors list (link)
• Oklü R, Hesketh R (2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem. J. 352 Pt 3: 601–10. PMID 11104663.
• Li X, Yin W, Pérez-Jurado L; et al. (1995). "Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2)". Mamm. Genome. 6 (1): 42–5. PMID 7719025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morén A, Olofsson A, Stenman G; et al. (1995). "Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein". J. Biol. Chem. 269 (51): 32469–78. PMID 7798248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bashir MM, Han MD, Abrams WR; et al. (1996). "Analysis of the human gene encoding latent transforming growth factor-beta-binding protein-2". Int. J. Biochem. Cell Biol. 28 (5): 531–42. PMID 8697098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hyytiäinen M, Taipale J, Heldin CH, Keski-Oja J (1998). "Recombinant latent transforming growth factor beta-binding protein 2 assembles to fibroblast extracellular matrix and is susceptible to proteolytic processing and release". J. Biol. Chem. 273 (32): 20669–76. PMID 9685426.CS1 maint: Multiple names: authors list (link)
• Saharinen J, Keski-Oja J (2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. PMID 10930463.
• Wu X, Blanck A, Norstedt G; et al. (2002). "Identification of genes with higher expression in human uterine leiomyomas than in the corresponding myometrium". Mol. Hum. Reprod. 8 (3): 246–54. PMID 11870232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heilig R, Eckenberg R, Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vehviläinen P, Hyytiäinen M, Keski-Oja J (2003). "Latent transforming growth factor-beta-binding protein 2 is an adhesion protein for melanoma cells". J. Biol. Chem. 278 (27): 24705–13. doi:10.1074/jbc.M212953200. PMID 12716902.CS1 maint: Multiple names: authors list (link)
• Hirani R, Hanssen E, Gibson MA (2007). "LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein". Matrix Biol. 26 (4): 213–23. doi:10.1016/j.matbio.2006.12.006. PMID 17293099.CS1 maint: Multiple names: authors list (link)