LPP (gene)

Revision as of 20:13, 8 November 2017 by en>JCW-CleanerBot (→‎Further reading: task using AWB)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[1][2]

Function

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[2]

References

  1. Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423.
  2. 2.0 2.1 "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.