LPP (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Lipoma-preferred partner''' is a [[protein]] that in humans is encoded by the ''LPP'' [[gene]].<ref name="pmid8812423">{{cite journal |vauthors=Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ | title = LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family | journal = Genomics | volume = 36 | issue = 1 | pages = 118–29 |date=Feb 1997 | pmid = 8812423 | pmc = | doi = 10.1006/geno.1996.0432 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4026| accessdate = }}</ref>
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = LIM domain containing preferred translocation partner in lipoma
| HGNCid = 6679
| Symbol = LPP
| AltSymbols =;
| OMIM = 600700
| ECnumber = 
| Homologene = 4075
| MGIid = 2441849
| GeneAtlas_image1 = PBB_GE_LPP_202821_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4026
    | Hs_Ensembl = ENSG00000145012
    | Hs_RefseqProtein = NP_005569
    | Hs_RefseqmRNA = NM_005578
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 189606603
    | Hs_GenLoc_end = 190074961
    | Hs_Uniprot = Q93052
    | Mm_EntrezGene = 210126
    | Mm_Ensembl = ENSMUSG00000033306
    | Mm_RefseqmRNA = NM_178665
    | Mm_RefseqProtein = NP_848780
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 24308839
    | Mm_GenLoc_end = 24896379
    | Mm_Uniprot = Q8BFW7
  }}
}}
'''LIM domain containing preferred translocation partner in lipoma''', also known as '''LPP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4026| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Lipoma-preferred partner is a subfamily of [[LIM domain]] proteins that are characterized by an [[N-terminus|N-terminal]] proline rich region and three [[C-terminus|C-terminal]] LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-[[cell adhesion]] and [[motility|cell motility]]. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of [[fusion protein]]s that may promote tumor growth.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Schoenmakers EF |title=Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours |journal=Nat. Genet. |volume=10 |issue= 4 |pages= 436–44 |year= 1995 |pmid= 7670494 |doi= 10.1038/ng0895-436  |name-list-format=vanc| author2=Wanschura S  | author3=Mols R | display-authors=3  | last4=Bullerdiek  | first4=Jörn  | last5=Van Den Berghe  | first5=Herman  | last6=Van De Ven  | first6=Wim J.M. }}
| citations =
*{{cite journal  |vauthors=Petit MM, Swarts S, Bridge JA, Van de Ven WJ |title=Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma |journal=Cancer Genet. Cytogenet. |volume=106 |issue= 1 |pages= 18–23 |year= 1998 |pmid= 9772904 |doi=10.1016/S0165-4608(98)00038-7 }}
*{{cite journal  | author=Schoenmakers EF, Wanschura S, Mols R, ''et al.'' |title=Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. |journal=Nat. Genet. |volume=10 |issue= 4 |pages= 436-44 |year= 1995 |pmid= 7670494 |doi= 10.1038/ng0895-436 }}
*{{cite journal  | author=Petit MM |title=LPP, an Actin Cytoskeleton Protein Related to Zyxin, Harbors a Nuclear Export Signal and Transcriptional Activation Capacity |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 117–29 |year= 2000 |pmid= 10637295 |doi=  10.1091/mbc.11.1.117| pmc=14761 |name-list-format=vanc| author2=Fradelizi J  | author3=Golsteyn RM  | display-authors=3 | last4=Ayoubi  | first4=TA  | last5=Menichi  | first5=B  | last6=Louvard  | first6=D  | last7=Van De Ven  | first7=WJ  | last8=Friederich  | first8=E }}
*{{cite journal | author=Petit MM, Mols R, Schoenmakers EF, ''et al.'' |title=LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. |journal=Genomics |volume=36 |issue= 1 |pages= 118-29 |year= 1997 |pmid= 8812423 |doi= 10.1006/geno.1996.0432 }}
*{{cite journal  |vauthors=Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J |title=An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15) |journal=Genes Chromosomes Cancer |volume=29 |issue= 4 |pages= 363–6 |year= 2001 |pmid= 11066083 |doi=10.1002/1098-2264(2000)9999:9999<1::AID-GCC1043>3.0.CO;2-N  }}
*{{cite journal  | author=Petit MM, Swarts S, Bridge JA, Van de Ven WJ |title=Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. |journal=Cancer Genet. Cytogenet. |volume=106 |issue= 1 |pages= 18-23 |year= 1998 |pmid= 9772904 |doi=  }}
*{{cite journal  | author=Harrington JJ |title=Creation of genome-wide protein expression libraries using random activation of gene expression |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 |name-list-format=vanc| author2=Sherf B  | author3=Rundlett S  | display-authors=3  | last4=Jackson  | first4=P. David  | last5=Perry  | first5=Rob  | last6=Cain  | first6=Scott  | last7=Leventhal  | first7=Christina  | last8=Thornton  | first8=Mark  | last9=Ramachandran | first9=Rakesh }}
*{{cite journal  | author=Petit MM, Fradelizi J, Golsteyn RM, ''et al.'' |title=LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. |journal=Mol. Biol. Cell |volume=11 |issue= 1 |pages= 117-29 |year= 2000 |pmid= 10637295 |doi=  }}
*{{cite journal  | author=Dahéron L |title=Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23) |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 382–9 |year= 2001 |pmid= 11433529 |doi= 10.1002/gcc.1157 |name-list-format=vanc| author2=Veinstein A  | author3=Brizard F | display-authors=3  | last4=Drabkin  | first4=Harry  | last5=Lacotte  | first5=Laurence  | last6=Guilhot  | first6=François  | last7=Larsen  | first7=Christian Jacques  | last8=Brizard  | first8=André  | last9=Roche | first9=Joelle }}
*{{cite journal | author=Rogalla P, Lemke I, Kazmierczak B, Bullerdiek J |title=An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). |journal=Genes Chromosomes Cancer |volume=29 |issue= 4 |pages= 363-6 |year= 2001 |pmid= 11066083 |doi=  }}
*{{cite journal  |vauthors=Lemke I, Rogalla P, Bullerdiek J |title=A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas |journal=Cytogenet. Cell Genet. |volume=95 |issue= 3–4 |pages= 153–6 |year= 2002 |pmid= 12063392 |doi=10.1159/000059338  }}
*{{cite journal  | author=Harrington JJ, Sherf B, Rundlett S, ''et al.'' |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440-5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107 }}
*{{cite journal  |vauthors=Petit MM, Meulemans SM, Van de Ven WJ |title=The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2157–68 |year= 2003 |pmid= 12441356 |doi= 10.1074/jbc.M206106200 }}
*{{cite journal  | author=Dahéron L, Veinstein A, Brizard F, ''et al.'' |title=Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23). |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 382-9 |year= 2001 |pmid= 11433529 |doi= 10.1002/gcc.1157 }}
*{{cite journal  | author=Lemke I |title=Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 2 |pages= 160–4 |year= 2003 |pmid= 12505264 |doi=10.1016/S0165-4608(02)00595-2  |name-list-format=vanc| author2=Rogalla P  | author3=Grundmann F  | display-authors=3  | last4=Kunze  | first4=Wolf-Peter  | last5=Haupt  | first5=Rolf  | last6=Bullerdiek  | first6=Jörn  }}
*{{cite journal | author=Lemke I, Rogalla P, Bullerdiek J |title=A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas. |journal=Cytogenet. Cell Genet. |volume=95 |issue= 3-4 |pages= 153-6 |year= 2002 |pmid= 12063392 |doi=  }}
*{{cite journal  | author=Salomon AR |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100  | pmc=141014 |name-list-format=vanc| author2=Ficarro SB  | author3=Brill LM  | display-authors=3  | last4=Brinker  | first4=A  | last5=Phung  | first5=QT  | last6=Ericson  | first6=C  | last7=Sauer  | first7=K  | last8=Brock  | first8=A  | last9=Horn  | first9=DM }}
*{{cite journal  | author=Petit MM, Meulemans SM, Van de Ven WJ |title=The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. |journal=J. Biol. Chem. |volume=278 |issue= 4 |pages= 2157-68 |year= 2003 |pmid= 12441356 |doi= 10.1074/jbc.M206106200 }}
*{{cite journal  |vauthors=Li B, Zhuang L, Reinhard M, Trueb B |title=The lipoma preferred partner LPP interacts with alpha-actinin |journal=J. Cell Sci. |volume=116 |issue= Pt 7 |pages= 1359–66 |year= 2003 |pmid= 12615977 |doi=10.1242/jcs.00309  }}
*{{cite journal | author=Lemke I, Rogalla P, Grundmann F, ''et al.'' |title=Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 2 |pages= 160-4 |year= 2003 |pmid= 12505264 |doi=  }}
*{{cite journal  | author=Gorenne I |title=LPP, a LIM protein highly expressed in smooth muscle |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 3 |pages= C674–85 |year= 2003 |pmid= 12760907 |doi= 10.1152/ajpcell.00608.2002 |name-list-format=vanc| author2=Nakamoto RK  | author3=Phelps CP  | display-authors=3  | last4=Beckerle  | first4=MC  | last5=Somlyo  | first5=AV  | last6=Somlyo  | first6=AP }}
*{{cite journal  | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal  | author=Brill LM |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d  |name-list-format=vanc| author2=Salomon AR  | author3=Ficarro SB  | display-authors=3  | last4=Mukherji  | first4=Mridul  | last5=Stettler-Gill  | first5=Michelle  | last6=Peters  | first6=Eric C. }}
*{{cite journal  | author=Li B, Zhuang L, Reinhard M, Trueb B |title=The lipoma preferred partner LPP interacts with alpha-actinin. |journal=J. Cell. Sci. |volume=116 |issue= Pt 7 |pages= 1359-66 |year= 2003 |pmid= 12615977 |doi= }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046  |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Gorenne I, Nakamoto RK, Phelps CP, ''et al.'' |title=LPP, a LIM protein highly expressed in smooth muscle. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 3 |pages= C674-85 |year= 2003 |pmid= 12760907 |doi= 10.1152/ajpcell.00608.2002 }}
*{{cite journal  | author=Petit MM |title=The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus |journal=BMC Cell Biol. |volume=6 |pages= 1 |year= 2006 |pmid= 15649318 |doi= 10.1186/1471-2121-6-1  | pmc=546208  |name-list-format=vanc| author2=Meulemans SM  | author3=Alen P  | display-authors=3  | last4=Ayoubi  | first4=Torik AY  | last5=Jansen  | first5=Erik  | last6=Van De Ven  | first6=Wim JM }}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal  | author=Zhang Y |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200  |name-list-format=vanc| author2=Wolf-Yadlin A  | author3=Ross PL  | display-authors=3  | last4=Pappin  | first4=DJ  | last5=Rush  | first5=J  | last6=Lauffenburger  | first6=DA  | last7=White  | first7=FM }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Tao WA |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776  |name-list-format=vanc| author2=Wollscheid B  | author3=O'Brien R  | display-authors=3  | last4=Eng  | first4=Jimmy K  | last5=Li  | first5=Xiao-jun  | last6=Bodenmiller  | first6=Bernd  | last7=Watts  | first7=Julian D  | last8=Hood  | first8=Leroy  | last9=Aebersold  | first9=Ruedi }}
*{{cite journal | author=Petit MM, Meulemans SM, Alen P, ''et al.'' |title=The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 1 |year= 2006 |pmid= 15649318 |doi= 10.1186/1471-2121-6-1 }}
*{{cite journal  |vauthors=von Ahsen I, Rogalla P, Bullerdiek J |title=Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15) |journal=Cancer Genet. Cytogenet. |volume=163 |issue= 1 |pages= 68–70 |year= 2006 |pmid= 16271958 |doi= 10.1016/j.cancergencyto.2005.02.023 }}
*{{cite journal  | author=Zhang Y, Wolf-Yadlin A, Ross PL, ''et al.'' |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell Proteomics |volume=4 |issue= 9 |pages= 1240-50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 }}
*{{cite journal  | author=Kubo T |title=Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 476–81 |year= 2006 |pmid= 16375854 |doi= 10.1016/j.bbrc.2005.12.042  |name-list-format=vanc| author2=Matsui Y  | author3=Goto T  | display-authors=3  | last4=Yukata  | first4=Kiminori  | last5=Yasui  | first5=Natsuo }}
*{{cite journal  | author=Tao WA, Wollscheid B, O'Brien R, ''et al.'' |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591-8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal | author=von Ahsen I, Rogalla P, Bullerdiek J |title=Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). |journal=Cancer Genet. Cytogenet. |volume=163 |issue= 1 |pages= 68-70 |year= 2006 |pmid= 16271958 |doi= 10.1016/j.cancergencyto.2005.02.023 }}
*{{cite journal  | author=Kubo T, Matsui Y, Goto T, ''et al.'' |title=Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. |journal=Biochem. Biophys. Res. Commun. |volume=340 |issue= 2 |pages= 476-81 |year= 2006 |pmid= 16375854 |doi= 10.1016/j.bbrc.2005.12.042 }}
}}
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Latest revision as of 20:13, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lipoma-preferred partner is a protein that in humans is encoded by the LPP gene.[1][2]

Function

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease related chromosomal translocations which result in the expression of fusion proteins that may promote tumor growth.[2]

References

  1. ↑ Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ (Feb 1997). "LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family". Genomics. 36 (1): 118–29. doi:10.1006/geno.1996.0432. PMID 8812423.
  2. ↑ 2.0 2.1 "Entrez Gene: LPP LIM domain containing preferred translocation partner in lipoma".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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