LMO2
| LIM domain only 2 (rhombotin-like 1) | |||||||||||
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| Symbols | LMO2 ; RBTN2; RBTNL1; RHOM2; TTG2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4072 | ||||||||||
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| File:PBB GE LMO2 204249 s at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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LIM domain only 2 (rhombotin-like 1), also known as LMO2, is a human gene.
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.[1]
References
Further reading
- Royer-Pokora B, Loos U, Ludwig WD (1991). "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)". Oncogene. 6 (10): 1887–93. PMID 1923511.
- Boehm T, Foroni L, Kaneko Y; et al. (1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4367–71. PMID 2034676.
- Boehm T, Spillantini MG, Sofroniew MV; et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression". Oncogene. 6 (5): 695–703. PMID 2052354.
- Dong WF, Xu Y, Hu QL; et al. (1995). "Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1". Leukemia. 9 (11): 1812–7. PMID 7475267.
- Osada H, Grutz G, Axelson H; et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. PMID 7568177.
- Sánchez-García I, Axelson H, Rabbitts TH (1995). "Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2". Oncogene. 10 (7): 1301–6. PMID 7731680.
- Wadman I, Li J, Bash RO; et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. PMID 7957052.
- Valge-Archer VE, Osada H, Warren AJ; et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. PMID 8078932.
- Wilkinson DA, Neale GA, Mao S; et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. PMID 9001422.
- Mao S, Neale GA, Goorha RM (1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene. 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143.
- Osada H, Grutz GG, Axelson H; et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 Suppl 3: 307–12. PMID 9209374.
- Wadman IA, Osada H, Grütz GG; et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins". EMBO J. 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMID 9214632.
- Visvader JE, Mao X, Fujiwara Y; et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. PMID 9391090.
- Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425.
- Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. PMID 9736723.
- Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3". Mol. Cell. Biol. 18 (12): 6939–50. PMID 9819382.
- Bach I, Rodriguez-Esteban C, Carrière C; et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247.
- Vitelli L, Condorelli G, Lulli V; et al. (2000). "A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts". Mol. Cell. Biol. 20 (14): 5330–42. PMID 10866689.
- Davenport J, Neale GA, Goorha R (2000). "Identification of genes potentially involved in LMO2-induced leukemogenesis". Leukemia. 14 (11): 1986–96. PMID 11069036.
- Sum EY, Peng B, Yu X; et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
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