LATS2

LATS, large tumor suppressor, homolog 2 (Drosophila)
Identifiers
Symbols	LATS2 ; FLJ13161; KPM
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56678
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LATS2 gnf1h02724 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

LATS, large tumor suppressor, homolog 2 (Drosophila), also known as LATS2, is a human gene.

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Further reading

• Yabuta N, Fujii T, Copeland NG; et al. (2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor". Oncogene. 19 (27): 3101–9. doi:10.1038/sj.onc.1203659. PMID 10871863.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Pei J, Xia H; et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition". Oncogene. 22 (28): 4398–405. doi:10.1038/sj.onc.1206603. PMID 12853976.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powzaniuk M, McElwee-Witmer S, Vogel RL; et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor". Mol. Endocrinol. 18 (8): 2011–23. doi:10.1210/me.2004-0065. PMID 15131260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Toji S, Yabuta N, Hosomi T; et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383–97. doi:10.1111/j.1356-9597.2004.00732.x. PMID 15147269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ke H, Pei J, Ni Z; et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res. 298 (2): 329–38. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan EH, Nousiainen M, Chalamalasetty RB; et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi Y, Miyoshi Y, Takahata C; et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers". Clin. Cancer Res. 11 (4): 1380–5. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Abe Y, Ohsugi M, Haraguchi K; et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Voorhoeve PM, le Sage C, Schrier M; et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors". Cell. 124 (6): 1169–81. doi:10.1016/j.cell.2006.02.037. PMID 16564011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aylon Y, Michael D, Shmueli A; et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization". Genes Dev. 20 (19): 2687–700. doi:10.1101/gad.1447006. PMID 17015431.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang Z, Li X, Hu J; et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)