Kupffer cell

Revision as of 16:44, 9 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

WikiDoc Resources for Kupffer cell

Articles

Most recent articles on Kupffer cell

Most cited articles on Kupffer cell

Review articles on Kupffer cell

Articles on Kupffer cell in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Kupffer cell

Images of Kupffer cell

Photos of Kupffer cell

Podcasts & MP3s on Kupffer cell

Videos on Kupffer cell

Evidence Based Medicine

Cochrane Collaboration on Kupffer cell

Bandolier on Kupffer cell

TRIP on Kupffer cell

Clinical Trials

Ongoing Trials on Kupffer cell at Clinical Trials.gov

Trial results on Kupffer cell

Clinical Trials on Kupffer cell at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Kupffer cell

NICE Guidance on Kupffer cell

NHS PRODIGY Guidance

FDA on Kupffer cell

CDC on Kupffer cell

Books

Books on Kupffer cell

News

Kupffer cell in the news

Be alerted to news on Kupffer cell

News trends on Kupffer cell

Commentary

Blogs on Kupffer cell

Definitions

Definitions of Kupffer cell

Patient Resources / Community

Patient resources on Kupffer cell

Discussion groups on Kupffer cell

Patient Handouts on Kupffer cell

Directions to Hospitals Treating Kupffer cell

Risk calculators and risk factors for Kupffer cell

Healthcare Provider Resources

Symptoms of Kupffer cell

Causes & Risk Factors for Kupffer cell

Diagnostic studies for Kupffer cell

Treatment of Kupffer cell

Continuing Medical Education (CME)

CME Programs on Kupffer cell

International

Kupffer cell en Espanol

Kupffer cell en Francais

Business

Kupffer cell in the Marketplace

Patents on Kupffer cell

Experimental / Informatics

List of terms related to Kupffer cell

Kupffer cells, also known as Browicz-Kupffer cells, are specialized macrophages located in the liver that form part of the reticuloendothelial system (aka: mononuclear phagocyte system). The cells were first observed by Karl Wilhelm von Kupffer in 1876.[1] The scientist called them "sternzellen" (star cells or stellate cells) but thought falsely that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. In 1898, after several years of research, Tadeusz Browicz, a polish sciencist, identified them correctly as macrophages. [2][3]

Their development begins in the bone marrow with the genesis of promonocytes and monoblasts into monocytes and then on to peripheral blood monocytes completing their differentiation into Kupffer cells.[4]

The primary function of Kupffer cells is to recycle old red blood cells that no longer are functional. The red blood cell is broken down by phagocytic action and the hemoglobin molecule is split. The globin chains are reutilized while the iron containing portion or heme is further broken down into iron which is reutilized and bilirubin, which is conjugated with glucuronic acid within hepatocytes and secreted into the bile.

Helmy et al. identified a receptor present in Kupffer cells, the complement receptor of the immunoglobulin family (CRIg). Mice without CRIg could not clear complement system-coated pathogens. CRIg is conserved in mice and humans and is a critical component of the innate immune system.[5]

References

  1. Haubrich WS. Kupffer of Kupffer cells. Gastroenterology 2004;127:16. PMID 15236167.
  2. Szymanska R, Schmidt-Pospula M. Studies of liver's reticuloendothelial cells by Tadeusz Browicz and Karl Kupffer. A historical outline. Arch Hist Med (Warsz). 1979;42(3):331-6. PMID 386989.
  3. Stachura J, Galazka K. History and current status of Polish gastroenterological pathology. J Physiol Pharmacol. 2003 Dec;54 Suppl 3:183-92. PMID 15075472.
  4. Naito M, Hasegawa G, Takahashi K. Development, differentiation, and maturation of Kupffer cells. Microsc Res Tech 1997;39:350-64. PMID 9407545.
  5. Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, Scales S, Ghilardi N, van Lookeren Campagne M (2006). "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens". Cell. 124 (5): 915–27. PMID 16530040.

External links


Template:Blood

de:Kupffer-Sternzelle it:Cellula di Kupffer fi:Kupfferin solu


Template:WikiDoc Sources