Klinefelter's syndrome historical perspective

Revision as of 15:04, 15 August 2012 by C Michael Gibson (talk | contribs) (→‎Historical Perspective)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Klinefelter's syndrome Microchapters


Patient Information


Historical Perspective


Differentiating Klinefelter's Syndrome from other Diseases

Epidemiology and Demographics

Natural History, Complications and Prognosis


History and Symptoms

Physical Examination

Laboratory Findings


Medical Therapy


Klinefelter's syndrome historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides


American Roentgen Ray Society Images of Klinefelter's syndrome historical perspective

All Images
Echo & Ultrasound
CT Images

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Klinefelter's syndrome historical perspective

CDC on Klinefelter's syndrome historical perspective

Klinefelter's syndrome historical perspective in the news

Blogs on Klinefelter's syndrome historical perspective

Directions to Hospitals Treating Klinefelter's syndrome

Risk calculators and risk factors for Klinefelter's syndrome historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Historical Perspective

The syndrome is named after Dr. Harry Klinefelter, an endocrinologist at Massachusetts General Hospital in Boston, MA, who first described it in 1942.[1]

The first published report of a man with a 47,XXY karyotype was by Patricia A. Jacobs and Dr. J.A. Strong at Western General Hospital in Edinburgh, Scotland in 1959.[2] This karyotype was found in a 24-year-old man who had signs of Klinefelter's syndrome. Dr. Jacobs described her discovery of this first reported human or mammalian chromosome aneuploidy in her 1981 William Allan Memorial Award address.[3]


  1. Klinefelter, HF Jr; Reifenstein, EC Jr; Albright (1942), "Syndrome characterized by gynecomastia, aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone.", J Clin Endocrinol Metab, 2: 615–624, PMID too early to be indexed ''too early to be indexed'' Check |pmid= value (help). Klinefelter, HF (1986), "Klinefelter's syndrome: historical background and development.", South Med J, 79 (45): 1089–1093, PMID 3529433 talks about the history of the development of the literature.
  2. Jacobs PA, Strong JA (1959). "A case of human intersexuality having a possible XXY sex-determining mechanism". Nature. 183 (4657): 302–3. doi:10.1038/183302a0. PMID 13632697. Unknown parameter |month= ignored (help)
  3. Jacobs PA (1982). "The William Allan Memorial Award address: human population cytogenetics: the first twenty-five years". Am J Hum Genet. 34 (5): 689–98. PMID 6751075. Unknown parameter |month= ignored (help)

Template:WH Template:WS