KLK7

Kallikrein-related peptidase 7
Identifiers
Symbols	KLK7 ; PRSS6; SCCE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37998
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLK7 205778 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein-related peptidase 7, also known as KLK7, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis. Alternative splicing of this gene results in two transcript variants encoding the same protein.

Further reading

• Skytt A, Strömqvist M, Egelrud T (1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme". Biochem. Biophys. Res. Commun. 211 (2): 586–9. doi:10.1006/bbrc.1995.1853. PMID 7794273.CS1 maint: Multiple names: authors list (link)
• Hansson L, Strömqvist M, Bäckman A; et al. (1994). "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase". J. Biol. Chem. 269 (30): 19420–6. PMID 8034709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Scorilas A, Magklara A; et al. (2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation". Gene. 254 (1–2): 119–28. PMID 10974542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gan L, Lee I, Smith R; et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dong Y, Kaushal A, Brattsand M; et al. (2004). "Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers". Clin. Cancer Res. 9 (5): 1710–20. PMID 12738725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Talieri M, Diamandis EP, Gourgiotis D; et al. (2004). "Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma". Thromb. Haemost. 91 (1): 180–6. doi:10.1267/THRO04010180. PMID 14691584.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diamandis EP, Scorilas A, Kishi T; et al. (2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia". Clin. Biochem. 37 (3): 230–7. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Caubet C, Jonca N, Brattsand M; et al. (2004). "Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7". J. Invest. Dermatol. 122 (5): 1235–44. doi:10.1111/j.0022-202X.2004.22512.x. PMID 15140227.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vasilopoulos Y, Cork MJ, Murphy R; et al. (2004). "Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis". J. Invest. Dermatol. 123 (1): 62–6. doi:10.1111/j.0022-202X.2004.22708.x. PMID 15191543.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Santin AD, Cane' S, Bellone S; et al. (2004). "The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells". Gynecol. Oncol. 94 (2): 283–8. doi:10.1016/j.ygyno.2004.05.023. PMID 15297163.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishida-Yamamoto A, Deraison C, Bonnart C; et al. (2005). "LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum". J. Invest. Dermatol. 124 (2): 360–6. doi:10.1111/j.0022-202X.2004.23583.x. PMID 15675955.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Planque C, de Monte M, Guyetant S; et al. (2005). "KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer". Biochem. Biophys. Res. Commun. 329 (4): 1260–6. doi:10.1016/j.bbrc.2005.02.100. PMID 15766562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Descargues P, Deraison C, Prost C; et al. (2006). "Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome". J. Invest. Dermatol. 126 (7): 1622–32. doi:10.1038/sj.jid.5700284. PMID 16628198.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol. Chem. 387 (6): 635–824. 2006. doi:10.1515/BC.2006.081. PMID 16800723.
• Lundwall A, Band V, Blaber M; et al. (2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol. Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamasaki K, Schauber J, Coda A; et al. (2006). "Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin". FASEB J. 20 (12): 2068–80. doi:10.1096/fj.06-6075com. PMID 17012259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Debela M, Hess P, Magdolen V; et al. (2007). "Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7". Proc. Natl. Acad. Sci. U.S.A. 104 (41): 16086–91. doi:10.1073/pnas.0707811104. PMID 17909180.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)