KLK12

Kallikrein-related peptidase 12
Identifiers
Symbols	KLK12 ; DKFZp686H1078; KLK-L5; KLKL5; MGC42603
External IDs	Template:OMIM5 Template:MGI HomoloGene: 44690
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE KLK12 220782 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein-related peptidase 12, also known as KLK12, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.

Further reading

• Diamandis EP, Yousef GM, Luo LY; et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. PMID 10675891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID 10652563.CS1 maint: Multiple names: authors list (link)
• Harvey TJ, Hooper JD, Myers SA; et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. doi:10.1006/bbrc.2000.3448. PMID 11006094.CS1 maint: Multiple names: authors list (link)
• Gan L, Lee I, Smith R; et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Magklara A, Diamandis EP (2001). "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer". Genomics. 69 (3): 331–41. doi:10.1006/geno.2000.6346. PMID 11056051.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shinmura K, Tao H, Yamada H; et al. (2005). "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity". Hum. Mutat. 24 (3): 273–4. doi:10.1002/humu.9270. PMID 15300858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol. Chem. 387 (6): 635–824. 2006. doi:10.1515/BC.2006.081. PMID 16800723.
• Lundwall A, Band V, Blaber M; et al. (2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol. Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Memari N, Jiang W, Diamandis EP, Luo LY (2007). "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)". Biol. Chem. 388 (4): 427–35. doi:10.1515/BC.2007.049. PMID 17391064.CS1 maint: Multiple names: authors list (link)