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{{Infobox_gene}}
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'''Kallikrein-11''' is a [[protein]] that in humans is encoded by the ''KLK11'' [[gene]].<ref name="pmid9765601">{{cite journal |vauthors=Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S | title = cDNA cloning and expression of a novel serine protease, TLSP | journal = Biochim Biophys Acta | volume = 1399 | issue = 2–3 | pages = 225–8 |date=Oct 1998 | pmid = 9765601 | pmc = | doi =  10.1016/s0167-4781(98)00116-x}}</ref><ref name="pmid10662548">{{cite journal |vauthors=Yousef GM, Scorilas A, Diamandis EP | title = Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family | journal = Genomics | volume = 63 | issue = 1 | pages = 88–96 |date=Apr 2000 | pmid = 10662548 | pmc =  | doi = 10.1006/geno.1999.6072 }}</ref><ref name="pmid16800724">{{cite journal |vauthors=Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM | title = A comprehensive nomenclature for serine proteases with homology to tissue kallikreins | journal = Biol Chem | volume = 387 | issue = 6 | pages = 637–41 |date=Jun 2006 | pmid = 16800724 | pmc = | doi = 10.1515/BC.2006.082 }}</ref><ref name="pmid16800723">{{cite journal | title = Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005 | journal = Biol Chem | volume = 387 | issue = 6 | pages = 635–824 |date=Jun 2006 | pmid = 16800723 | pmc = | doi = 10.1515/BC.2006.081 | last1 = Diamandis | first1 = Eleftherios P. | last2 = Deperthes | first2 = David | last3 =  Lundwall | first3 = Åke }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLK11 kallikrein-related peptidase 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11012| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kallikrein-related peptidase 11
| HGNCid = 6359
| Symbol = KLK11
| AltSymbols =; MGC33060; PRSS20; TLSP
| OMIM = 604434
| ECnumber =
| Homologene = 27048
| MGIid = 1929977
  | GeneAtlas_image1 = PBB_GE_KLK11_205470_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11012
    | Hs_Ensembl = ENSG00000167757
    | Hs_RefseqProtein = NP_006844
    | Hs_RefseqmRNA = NM_006853
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 56217301
    | Hs_GenLoc_end = 56223107
    | Hs_Uniprot = Q9UBX7
    | Mm_EntrezGene = 56538
    | Mm_Ensembl = ENSMUSG00000067616
    | Mm_RefseqmRNA = NM_019974
    | Mm_RefseqProtein = NP_064358
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 43642659
    | Mm_GenLoc_end = 43647300
    | Mm_Uniprot = Q14BZ7
  }}
}}
'''Kallikrein-related peptidase 11''', also known as '''KLK11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLK11 kallikrein-related peptidase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11012| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.<ref name="entrez">{{cite web | title = Entrez Gene: KLK11 kallikrein-related peptidase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11012| accessdate = }}</ref>
| summary_text = Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Yoshida S, Taniguchi M, Suemoto T, ''et al.'' |title=cDNA cloning and expression of a novel serine protease, TLSP. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 2-3 |pages= 225-8 |year= 1998 |pmid= 9765601 |doi=  }}
*{{cite journal   |vauthors=Mitsui S, Yamada T, Okui A, etal |title=A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 205–11 |year= 2000 |pmid= 10872828 |doi= 10.1006/bbrc.2000.2761 }}
*{{cite journal  | author=Yousef GM, Scorilas A, Diamandis EP |title=Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. |journal=Genomics |volume=63 |issue= 1 |pages= 88-96 |year= 2000 |pmid= 10662548 |doi= 10.1006/geno.1999.6072 }}
*{{cite journal   |vauthors=Gan L, Lee I, Smith R, etal |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region |journal=Gene |volume=257 |issue= 1 |pages= 119–30 |year= 2001 |pmid= 11054574 |doi=10.1016/S0378-1119(00)00382-6 }}
*{{cite journal  | author=Mitsui S, Yamada T, Okui A, ''et al.'' |title=A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 205-11 |year= 2000 |pmid= 10872828 |doi= 10.1006/bbrc.2000.2761 }}
*{{cite journal   |vauthors=Nakamura T, Mitsui S, Okui A, etal |title=Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines |journal=Prostate |volume=49 |issue= 1 |pages= 72–8 |year= 2002 |pmid= 11550212 |doi=10.1002/pros.1119 }}
*{{cite journal | author=Gan L, Lee I, Smith R, ''et al.'' |title=Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. |journal=Gene |volume=257 |issue= 1 |pages= 119-30 |year= 2001 |pmid= 11054574 |doi=  }}
*{{cite journal   |vauthors=Diamandis EP, Okui A, Mitsui S, etal |title=Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma |journal=Cancer Res. |volume=62 |issue= 1 |pages= 295–300 |year= 2002 |pmid= 11782391 |doi=  }}
*{{cite journal | author=Nakamura T, Mitsui S, Okui A, ''et al.'' |title=Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines. |journal=Prostate |volume=49 |issue= 1 |pages= 72-8 |year= 2002 |pmid= 11550212 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Diamandis EP, Okui A, Mitsui S, ''et al.'' |title=Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 295-300 |year= 2002 |pmid= 11782391 |doi=  }}
*{{cite journal   |vauthors=Nakamura T, Mitsui S, Okui A, etal |title=Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate |journal=Prostate |volume=54 |issue= 4 |pages= 299–305 |year= 2003 |pmid= 12539228 |doi= 10.1002/pros.10191 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nakamura T, Stephan C, Scorilas A, etal |title=Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues |journal=Urology |volume=61 |issue= 5 |pages= 1042–6 |year= 2003 |pmid= 12736044 |doi=10.1016/S0090-4295(02)02443-3 }}
*{{cite journal | author=Nakamura T, Mitsui S, Okui A, ''et al.'' |title=Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate. |journal=Prostate |volume=54 |issue= 4 |pages= 299-305 |year= 2003 |pmid= 12539228 |doi= 10.1002/pros.10191 }}
*{{cite journal   |vauthors=Borgoño CA, Fracchioli S, Yousef GM, etal |title=Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma |journal=Int. J. Cancer |volume=106 |issue= 4 |pages= 605–10 |year= 2003 |pmid= 12845660 |doi= 10.1002/ijc.11296 }}
*{{cite journal | author=Nakamura T, Stephan C, Scorilas A, ''et al.'' |title=Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues. |journal=Urology |volume=61 |issue= 5 |pages= 1042-6 |year= 2003 |pmid= 12736044 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Borgoño CA, Fracchioli S, Yousef GM, ''et al.'' |title=Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma. |journal=Int. J. Cancer |volume=106 |issue= 4 |pages= 605-10 |year= 2003 |pmid= 12845660 |doi= 10.1002/ijc.11296 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Shigemasa K, Gu L, Tanimoto H, etal |title=Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer |journal=Clin. Cancer Res. |volume=10 |issue= 8 |pages= 2766–70 |year= 2004 |pmid= 15102682 |doi=10.1158/1078-0432.CCR-03-0269 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Diamandis EP, Borgoño CA, Scorilas A, etal |title=Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients |journal=Clin. Biochem. |volume=37 |issue= 9 |pages= 823–9 |year= 2005 |pmid= 15329323 |doi= 10.1016/j.clinbiochem.2004.04.009 }}
*{{cite journal | author=Shigemasa K, Gu L, Tanimoto H, ''et al.'' |title=Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 8 |pages= 2766-70 |year= 2004 |pmid= 15102682 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Diamandis EP, Borgoño CA, Scorilas A, ''et al.'' |title=Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients. |journal=Clin. Biochem. |volume=37 |issue= 9 |pages= 823-9 |year= 2005 |pmid= 15329323 |doi= 10.1016/j.clinbiochem.2004.04.009 }}
*{{cite journal  |vauthors=Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A |title=Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer |journal=Clin. Chim. Acta |volume=357 |issue= 2 |pages= 190–5 |year= 2005 |pmid= 15893744 |doi= 10.1016/j.cccn.2005.03.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Planque C, Aïnciburu M, Heuzé-Vourc'h N, etal |title=Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 783–8 |year= 2006 |pmid= 16800740 |doi= 10.1515/BC.2006.098 }}
*{{cite journal  | author=Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A |title=Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer. |journal=Clin. Chim. Acta |volume=357 |issue= 2 |pages= 190-5 |year= 2005 |pmid= 15893744 |doi= 10.1016/j.cccn.2005.03.026 }}
*{{cite journal   |vauthors=Mitsui S, Nakamura T, Okui A, etal |title=Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin |journal=FEBS J. |volume=273 |issue= 16 |pages= 3678–86 |year= 2006 |pmid= 16911518 |doi= 10.1111/j.1742-4658.2006.05372.x }}
*{{cite journal | author= |title=Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 635-824 |year= 2006 |pmid= 16800723 |doi= 10.1515/BC.2006.081 }}
*{{cite journal  | author=Lundwall A, Band V, Blaber M, ''et al.'' |title=A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 637-41 |year= 2006 |pmid= 16800724 |doi= 10.1515/BC.2006.082 }}
*{{cite journal  | author=Planque C, Aïnciburu M, Heuzé-Vourc'h N, ''et al.'' |title=Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues. |journal=Biol. Chem. |volume=387 |issue= 6 |pages= 783-8 |year= 2006 |pmid= 16800740 |doi= 10.1515/BC.2006.098 }}
*{{cite journal | author=Mitsui S, Nakamura T, Okui A, ''et al.'' |title=Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin. |journal=FEBS J. |volume=273 |issue= 16 |pages= 3678-86 |year= 2006 |pmid= 16911518 |doi= 10.1111/j.1742-4658.2006.05372.x }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=S01.257 S01.257]
 
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{{gene-19-stub}}

Latest revision as of 06:32, 2 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.[1][2][3][4][5]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.[5]

References

  1. ↑ Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (Oct 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochim Biophys Acta. 1399 (2–3): 225–8. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.
  2. ↑ Yousef GM, Scorilas A, Diamandis EP (Apr 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.
  3. ↑ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.
  4. ↑ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723.
  5. ↑ 5.0 5.1 "Entrez Gene: KLK11 kallikrein-related peptidase 11".

Further reading

External links

  • The MEROPS online database for peptidases and their inhibitors: S01.257



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