KLF10: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Krueppel-like factor 10''' is a [[protein]] that in humans is encoded by the ''KLF10'' [[gene]].<ref name="pmid8584037">{{cite journal |vauthors=Blok LJ, Grossmann ME, Perry JE, Tindall DJ | title = Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation | journal = Mol Endocrinol | volume = 9 | issue = 11 | pages = 1610–20 |date=Mar 1996 | pmid = 8584037 | pmc =  | doi =10.1210/me.9.11.1610  }}</ref><ref name="pmid9721211">{{cite journal |vauthors=Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED | title = TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters | journal = Genomics | volume = 51 | issue = 3 | pages = 408–16 |date=Oct 1998 | pmid = 9721211 | pmc =  | doi = 10.1006/geno.1998.5388 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KLF10 Kruppel-like factor 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7071| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Kruppel-like factor 10
| HGNCid = 11810
| Symbol = KLF10
| AltSymbols =; EGRA; TIEG; TIEG1
| OMIM = 601878
| ECnumber = 
| Homologene = 4135
| MGIid = 1101353
| GeneAtlas_image1 = PBB_GE_KLF10_202393_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030282 |text = bone mineralization}} {{GNF_GO|id=GO:0045672 |text = positive regulation of osteoclast differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7071
    | Hs_Ensembl = ENSG00000155090
    | Hs_RefseqProtein = NP_001027453
    | Hs_RefseqmRNA = NM_001032282
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 103730189
    | Hs_GenLoc_end = 103737127
    | Hs_Uniprot = Q13118
    | Mm_EntrezGene = 21847
    | Mm_Ensembl = ENSMUSG00000037465
    | Mm_RefseqmRNA = NM_013692
    | Mm_RefseqProtein = NP_038720
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 38239002
    | Mm_GenLoc_end = 38245298
    | Mm_Uniprot = Q3U3K0
  }}
}}
'''Kruppel-like factor 10''', also known as '''KLF10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF10 Kruppel-like factor 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7071| accessdate = }}</ref>
 
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{{PBB_Summary
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| summary_text =  
}}
}}
==See also==
==See also==
* [[Kruppel-like factors]]
* [[Kruppel-like factors]]


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Subramaniam M, Harris SA, Oursler MJ, ''et al.'' |title=Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. |journal=Nucleic Acids Res. |volume=23 |issue= 23 |pages= 4907-12 |year= 1996 |pmid= 8532536 |doi=  }}
*{{cite journal   |vauthors=Subramaniam M, Harris SA, Oursler MJ, etal |title=Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. |journal=Nucleic Acids Res. |volume=23 |issue= 23 |pages= 4907–12 |year= 1996 |pmid= 8532536 |doi=10.1093/nar/23.23.4907  | pmc=307482 }}
*{{cite journal | author=Blok LJ, Grossmann ME, Perry JE, Tindall DJ |title=Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. |journal=Mol. Endocrinol. |volume=9 |issue= 11 |pages= 1610-20 |year= 1996 |pmid= 8584037 |doi=  }}
*{{cite journal   |vauthors=Tachibana I, Imoto M, Adjei PN, etal |title=Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. |journal=J. Clin. Invest. |volume=99 |issue= 10 |pages= 2365–74 |year= 1997 |pmid= 9153278 |doi=10.1172/JCI119418  | pmc=508075 }}
*{{cite journal | author=Tachibana I, Imoto M, Adjei PN, ''et al.'' |title=Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. |journal=J. Clin. Invest. |volume=99 |issue= 10 |pages= 2365-74 |year= 1997 |pmid= 9153278 |doi= }}
*{{cite journal   |vauthors=Subramaniam M, Hefferan TE, Tau K, etal |title=Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene. |journal=J. Cell. Biochem. |volume=68 |issue= 2 |pages= 226–36 |year= 1998 |pmid= 9443078 |doi=10.1002/(SICI)1097-4644(19980201)68:2<226::AID-JCB9>3.0.CO;2-X  }}
*{{cite journal | author=Subramaniam M, Hefferan TE, Tau K, ''et al.'' |title=Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene. |journal=J. Cell. Biochem. |volume=68 |issue= 2 |pages= 226-36 |year= 1998 |pmid= 9443078 |doi=  }}
*{{cite journal   |vauthors=Cook T, Gebelein B, Mesa K, etal |title=Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25929–36 |year= 1998 |pmid= 9748269 |doi=10.1074/jbc.273.40.25929 }}
*{{cite journal | author=Fautsch MP, Vrabel A, Subramaniam M, ''et al.'' |title=TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters. |journal=Genomics |volume=51 |issue= 3 |pages= 408-16 |year= 1998 |pmid= 9721211 |doi= 10.1006/geno.1998.5388 }}
*{{cite journal   |vauthors=Hefferan TE, Reinholz GG, Rickard DJ, etal |title=Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20255–9 |year= 2000 |pmid= 10816551 |doi= 10.1074/jbc.C000135200 }}
*{{cite journal  | author=Cook T, Gebelein B, Mesa K, ''et al.'' |title=Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25929-36 |year= 1998 |pmid= 9748269 |doi=  }}
*{{cite journal  |vauthors=Gunther M, Laithier M, Brison O |title=A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. |journal=Mol. Cell. Biochem. |volume=210 |issue= 1-2 |pages= 131–42 |year= 2000 |pmid= 10976766 |doi=10.1023/A:1007177623283 }}
*{{cite journal | author=Hefferan TE, Reinholz GG, Rickard DJ, ''et al.'' |title=Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20255-9 |year= 2000 |pmid= 10816551 |doi= 10.1074/jbc.C000135200 }}
*{{cite journal   |vauthors=Antonello D, Moore PS, Zamboni G, etal |title=Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer. |journal=Cancer Lett. |volume=183 |issue= 2 |pages= 179–83 |year= 2002 |pmid= 12065093 |doi=10.1016/S0304-3835(01)00802-3  }}
*{{cite journal | author=Gunther M, Laithier M, Brison O |title=A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening. |journal=Mol. Cell. Biochem. |volume=210 |issue= 1-2 |pages= 131-42 |year= 2000 |pmid= 10976766 |doi= }}
*{{cite journal   |vauthors=Johnsen SA, Subramaniam M, Monroe DG, etal |title=Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30754–9 |year= 2002 |pmid= 12072443 |doi= 10.1074/jbc.M204812200 }}
*{{cite journal  | author=Antonello D, Moore PS, Zamboni G, ''et al.'' |title=Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer. |journal=Cancer Lett. |volume=183 |issue= 2 |pages= 179-83 |year= 2002 |pmid= 12065093 |doi= }}
*{{cite journal  |vauthors=Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC |title=TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. |journal=Oncogene |volume=21 |issue= 37 |pages= 5783–90 |year= 2002 |pmid= 12173049 |doi= 10.1038/sj.onc.1205681 }}
*{{cite journal | author=Johnsen SA, Subramaniam M, Monroe DG, ''et al.'' |title=Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30754-9 |year= 2002 |pmid= 12072443 |doi= 10.1074/jbc.M204812200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC |title=TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. |journal=Oncogene |volume=21 |issue= 37 |pages= 5783-90 |year= 2002 |pmid= 12173049 |doi= 10.1038/sj.onc.1205681 }}
*{{cite journal  |vauthors=Chrisman HR, Tindall DJ |title=Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. |journal=DNA Cell Biol. |volume=22 |issue= 3 |pages= 187–99 |year= 2003 |pmid= 12804117 |doi= 10.1089/104454903321655819 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Noti JD, Johnson AK, Dillon JD |title=The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 26948–58 |year= 2004 |pmid= 15087465 |doi= 10.1074/jbc.M310634200 }}
*{{cite journal | author=Chrisman HR, Tindall DJ |title=Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. |journal=DNA Cell Biol. |volume=22 |issue= 3 |pages= 187-99 |year= 2003 |pmid= 12804117 |doi= 10.1089/104454903321655819 }}
*{{cite journal   |vauthors=Reinholz MM, An MW, Johnsen SA, etal |title=Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. |journal=Breast Cancer Res. Treat. |volume=86 |issue= 1 |pages= 75–88 |year= 2004 |pmid= 15218362 |doi= 10.1023/B:BREA.0000032926.74216.7d }}
*{{cite journal  | author=Noti JD, Johnson AK, Dillon JD |title=The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 26948-58 |year= 2004 |pmid= 15087465 |doi= 10.1074/jbc.M310634200 }}
*{{cite journal  |vauthors=Johnsen SA, Subramaniam M, Effenberger KE, Spelsberg TC |title= The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ. |journal=Signal Transduction |volume=4 |pages= 29–35 |year= 2004 |doi= 10.1002/sita.200400032 }}
*{{cite journal | author=Reinholz MM, An MW, Johnsen SA, ''et al.'' |title=Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue. |journal=Breast Cancer Res. Treat. |volume=86 |issue= 1 |pages= 75-88 |year= 2004 |pmid= 15218362 |doi= 10.1023/B:BREA.0000032926.74216.7d }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author= Johnsen SA, Subramaniam M, Effenberger KE, and Spelsberg TC |title= The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ. |journal=Signal Transduction |volume=4 |pages= 29-35 |year= 2004 |doi= 10.1002/sita.200400032 }}
*{{cite journal  |vauthors=Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC |title= TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro. |journal=Mol. Cell. Biol. |volume=25 |pages= 1191–1199 |year= 2005 |pmid= 15657444 |doi= 10.1128/MCB.25.3.1191-1199.2005 | issue=3  | pmc=543998 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JMA, Turner RT, Oursler MJ, and Spelsberg TC |title= TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro. |journal=Mol. Cell. Biol. |volume=25 |pages= 1191-1199 |year= 2005 |pmid= 15657444 |doi= 10.1128/MCB.25.3.1191-1199.2005 }}
*{{cite journal   |vauthors=Fueki N, Sagara H, Akimoto K, etal |title=Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells. |journal=Respiration; international review of thoracic diseases |volume=74 |issue= 4 |pages= 454–9 |year= 2007 |pmid= 17377371 |doi= 10.1159/000101057 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Jin W, Di G, Li J, etal |title=TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. |journal=FEBS Lett. |volume=581 |issue= 20 |pages= 3826–32 |year= 2007 |pmid= 17659279 |doi= 10.1016/j.febslet.2007.07.008 }}
*{{cite journal | author=Fueki N, Sagara H, Akimoto K, ''et al.'' |title=Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells. |journal=Respiration; international review of thoracic diseases |volume=74 |issue= 4 |pages= 454-9 |year= 2007 |pmid= 17377371 |doi= 10.1159/000101057 }}
*{{cite journal  |vauthors=Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC |title= TIEG1: An Important Regulator of Multiple Biological Processes and Disease States. |journal=J. Cell. Biochem. |volume=102 |issue= 3 |pages= 539–548 |year= 2007 |pmid= 17729309 |doi= 10.1002/jcb.21492 }}
*{{cite journal | author=Jin W, Di G, Li J, ''et al.'' |title=TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade. |journal=FEBS Lett. |volume=581 |issue= 20 |pages= 3826-32 |year= 2007 |pmid= 17659279 |doi= 10.1016/j.febslet.2007.07.008 }}
*{{cite journal  | author= Subramaniam M, Hawse JR, Johnsen SA, and Spelsberg TC |title= TIEG1: An Important Regulator of Multiple Biological Processes and Disease States. |journal=J. Cell. Biochem. |volume=102 |issue= 3 |pages= 539-548 |year= 2007 |pmid= 17729309 |doi= 10.1002/jcb.21492 }}
}}
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{{Transcription factors}}
{{Transcription factors|g2}}
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[[Category:Transcription factors]]
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Latest revision as of 16:41, 16 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.[1][2][3]

See also

References

  1. ↑ Blok LJ, Grossmann ME, Perry JE, Tindall DJ (Mar 1996). "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation". Mol Endocrinol. 9 (11): 1610–20. doi:10.1210/me.9.11.1610. PMID 8584037.
  2. ↑ Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED (Oct 1998). "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters". Genomics. 51 (3): 408–16. doi:10.1006/geno.1998.5388. PMID 9721211.
  3. ↑ "Entrez Gene: KLF10 Kruppel-like factor 10".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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