KCNU1

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Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.^[1]

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.^[2]^[3]^[4]

References

↑ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
↑ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
↑ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
↑ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid9452476-1] Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.

[Wei-2] Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.

[pmid16940554-3] Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.

[pmid16940555-4] Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

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[2]

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KCNU1

References

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