KCNJ14

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External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
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Wikidata
View/Edit Human

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as K_ir2.4, is a human gene.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Töpert C, Döring F, Wischmeyer E, et al. (1998). "Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei". J. Neurosci. 18 (11): 4096–105. PMID 9592090.
• Töpert C, Döring F, Derst C, et al. (2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)". Mamm. Genome. 11 (3): 247–9. doi:10.1007/s003350010047. PMID 10723734.
• Hughes BA, Kumar G, Yuan Y, et al. (2000). "Cloning and functional expression of human retinal kir2.4, a pH-sensitive inwardly rectifying K(+) channel". Am. J. Physiol., Cell Physiol. 279 (3): C771–84. PMID 10942728.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fang Y, Schram G, Romanenko VG, et al. (2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". Am. J. Physiol., Cell Physiol. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.
• Tennant BP, Cui Y, Tinker A, Clapp LH (2007). "Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits". J. Membr. Biol. 213 (1): 19–29. doi:10.1007/s00232-006-0037-y. PMC 1973150. PMID 17347781.

External links

• KCNJ14+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.