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Potassium voltage-gated channel subfamily C member 1 is a protein that in humans is encoded by the KCNC1gene.[1][2][3]
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and comprises four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.[3]
Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[5][7] Kv3.1 channels are important for the high-firing frequency of auditory and fast-spiking GABAergic interneurons, retinal ganglion cells; regulation of action potential duration in presynaptic terminals.[4][6]
Pharmacological properties
Kv3.1 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC50 values are 0.2 mM and 29 μM respectively).[5][6] This can be useful in identifying native channels.[5] The overlapping sensitivity of potassium current to both 0.5 mM TEA and 30 μM 4-AP strongly suggest an action on Kv3.1 subunits.[8]
↑Ried T, Rudy B, Vega-Saenz de Miera E, Lau D, Ward DC, Sen K (Apr 1993). "Localization of a highly conserved human potassium channel gene (NGK2-KV4; KCNC1) to chromosome 11p15". Genomics. 15 (2): 405–11. doi:10.1006/geno.1993.1075. PMID8449507.
↑Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID16382104.
↑Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of Kv3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID10414303.
↑Muona M, Berkovic SF, Dibbens LM, Oliver KL, Maljevic S, Bayly MA, Joensuu T, Canafoglia L, Franceschetti S, Michelucci R, Markkinen S, Heron SE, Hildebrand MS, Andermann E, Andermann F, Gambardella A, Tinuper P, Licchetta L, Scheffer IE, Criscuolo C, Filla A, Ferlazzo E, Ahmad J, Ahmad A, Baykan B, Said E, Topcu M, Riguzzi P, King MD, Ozkara C, Andrade DM, Engelsen BA, Crespel A, Lindenau M, Lohmann E, Saletti V, Massano J, Privitera M, Espay AJ, Kauffmann B, Duchowny M, Møller RS, Straussberg R, Afawi Z, Ben-Zeev B, Samocha KE, Daly MJ, Petrou S, Lerche H, Palotie A, Lehesjoki AE (2015). "A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy". Nature Genetics. 47 (1): 39–46. doi:10.1038/ng.3144. PMC4281260. PMID25401298.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Devaux J, Alcaraz G, Grinspan J, et al. (2003). "Kv3.1b is a novel component of CNS nodes". J. Neurosci. 23 (11): 4509–18. PMID12805291.
Xu J, Yu W, Jan YN, et al. (1995). "Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits". J. Biol. Chem. 270 (42): 24761–8. doi:10.1074/jbc.270.42.24761. PMID7559593.
Grissmer S, Ghanshani S, Dethlefs B, et al. (1992). "The Shaw-related potassium channel gene, Kv3.1, on human chromosome 11, encodes the type l K+ channel in T cells". J. Biol. Chem. 267 (29): 20971–9. PMID1400413.