Irritable bowel syndrome causes: Difference between revisions
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==Overview== | ==Overview== | ||
There is no definite cause that has been established for irritable bowel syndrome (IBS). However, | There is no definite cause that has been established for [[irritable bowel syndrome]] ([[Irritable bowel syndrome|IBS]]). However, an interplay of several factors contribute to the development of [[Irritable bowel syndrome|IBS]] such as [[Emotion|emotional]] disturbances, [[Stress (medicine)|stress]], adverse early life events, history of [[inflammatory bowel disease]], and acute [[Gastrointestinal tract|gastrointestinal]] [[Infection|infections]]. Less common causes of IBS include [[genetics]] and [[Hormone|hormonal]] changes. | ||
==Causes== | ==Causes== | ||
Irritable bowel syndrome (IBS) results from a complex interaction among multiple factors. These may include [[Psychological Science (journal)|psychological]], [[Epidemiology|epidemiological]], [[Genetics|genetic]], and [[Infection|infectious]] factors. To review these factors in detail, '''[[Irritable bowel syndrome risk factors|click here]].''' | [[Irritable bowel syndrome]] ([[Irritable bowel syndrome|IBS]]) results from a complex interaction among multiple factors. These may include [[Psychological Science (journal)|psychological]], [[Epidemiology|epidemiological]], [[Genetics|genetic]], and [[Infection|infectious]] factors. To review these factors in detail, '''[[Irritable bowel syndrome risk factors|click here]].''' | ||
===Genetic Causes=== | ===Genetic Causes=== | ||
Genetic causes of inflammatory bowel disease (IBS) include:<ref name="pmid26525775">{{cite journal |vauthors=Makker J, Chilimuri S, Bella JN |title=Genetic epidemiology of irritable bowel syndrome |journal=World J. Gastroenterol. |volume=21 |issue=40 |pages=11353–61 |year=2015 |pmid=26525775 |pmc=4616211 |doi=10.3748/wjg.v21.i40.11353 |url=}}</ref><ref name="pmid21602989">{{cite journal |vauthors=Tanaka Y, Kanazawa M, Fukudo S, Drossman DA |title=Biopsychosocial model of irritable bowel syndrome |journal=J Neurogastroenterol Motil |volume=17 |issue=2 |pages=131–9 |year=2011 |pmid=21602989 |pmc=3093004 |doi=10.5056/jnm.2011.17.2.131 |url=}}</ref> | Genetic causes of inflammatory bowel disease (IBS) include:<ref name="pmid26525775">{{cite journal |vauthors=Makker J, Chilimuri S, Bella JN |title=Genetic epidemiology of irritable bowel syndrome |journal=World J. Gastroenterol. |volume=21 |issue=40 |pages=11353–61 |year=2015 |pmid=26525775 |pmc=4616211 |doi=10.3748/wjg.v21.i40.11353 |url=}}</ref><ref name="pmid21602989">{{cite journal |vauthors=Tanaka Y, Kanazawa M, Fukudo S, Drossman DA |title=Biopsychosocial model of irritable bowel syndrome |journal=J Neurogastroenterol Motil |volume=17 |issue=2 |pages=131–9 |year=2011 |pmid=21602989 |pmc=3093004 |doi=10.5056/jnm.2011.17.2.131 |url=}}</ref> | ||
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*Other [[Gene|genes]] such as [[Tumour necrosis factor|tumor necrosis factor]] alpha (TNFα) and genes coding for superfamily member 15 (''TNFSF15'') are also involved. | *Other [[Gene|genes]] such as [[Tumour necrosis factor|tumor necrosis factor]] alpha (TNFα) and genes coding for superfamily member 15 (''TNFSF15'') are also involved. | ||
*SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-[[Gut flora|microbiota]] interaction (TLR9, IL-6 and CDH1), [[Immunity (medical)|immune]] activation, and [[Epithelium|epithelial]] barriers. | *[[Single nucleotide polymorphism|SNPs (Single Nucleotide Polymorphisms)]] in [[Gene|genes]] play an important role in host-[[Gut flora|microbiota]] interaction (TLR9, IL-6 and CDH1), [[Immunity (medical)|immune]] activation, and [[Epithelium|epithelial]] barriers. | ||
*Genes involved in the regulation of [[Liver|hepatic]] [[bile acid]] synthesis such as a functional Klothoβ gene variant are mutated in IBS patients. | *Genes involved in the [[Regulation of gene expression|regulation]] of [[Liver|hepatic]] [[bile acid]] synthesis such as a functional ''Klothoβ'' [[gene]] variant are [[Mutation|mutated]] in [[Irritable bowel syndrome|IBS]] [[Patient|patients]]. | ||
*Genome wide DNA methylation profiling is different in IBS patients, especially involving [[Gene|genes]] linked to [[neuropeptide]] [[hormone]] function and [[oxidative stress]]. | *[[Genome]] wide [[DNA methylation]] profiling is different in [[Irritable bowel syndrome|IBS]] patients, especially involving [[Gene|genes]] linked to [[neuropeptide]] [[hormone]] function and [[oxidative stress]]. | ||
==References== | ==References== | ||
Revision as of 00:43, 31 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no definite cause that has been established for irritable bowel syndrome (IBS). However, an interplay of several factors contribute to the development of IBS such as emotional disturbances, stress, adverse early life events, history of inflammatory bowel disease, and acute gastrointestinal infections. Less common causes of IBS include genetics and hormonal changes.
Causes
Irritable bowel syndrome (IBS) results from a complex interaction among multiple factors. These may include psychological, epidemiological, genetic, and infectious factors. To review these factors in detail, click here.
Genetic Causes
Genetic causes of inflammatory bowel disease (IBS) include:[1][2]
- IBS is caused by a mutation of type V (alpha subunit) of SCN5A-encoded voltage gated sodium channel gene.
- Other genes such as tumor necrosis factor alpha (TNFα) and genes coding for superfamily member 15 (TNFSF15) are also involved.
- SNPs (Single Nucleotide Polymorphisms) in genes play an important role in host-microbiota interaction (TLR9, IL-6 and CDH1), immune activation, and epithelial barriers.
- Genes involved in the regulation of hepatic bile acid synthesis such as a functional Klothoβ gene variant are mutated in IBS patients.
- Genome wide DNA methylation profiling is different in IBS patients, especially involving genes linked to neuropeptide hormone function and oxidative stress.
References
- ↑ Makker J, Chilimuri S, Bella JN (2015). "Genetic epidemiology of irritable bowel syndrome". World J. Gastroenterol. 21 (40): 11353–61. doi:10.3748/wjg.v21.i40.11353. PMC 4616211. PMID 26525775.
- ↑ Tanaka Y, Kanazawa M, Fukudo S, Drossman DA (2011). "Biopsychosocial model of irritable bowel syndrome". J Neurogastroenterol Motil. 17 (2): 131–9. doi:10.5056/jnm.2011.17.2.131. PMC 3093004. PMID 21602989.