Intracerebral metastases natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
Line 26: Line 26:
*The primary tumor-specific prognosis of intracerebral metastases are tabulated below:<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref>
*The primary tumor-specific prognosis of intracerebral metastases are tabulated below:<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref>


{|  style="border: 0px; font-size: 90%; margin: 3px; width:1000px"
{|  style="border: 0px; font-size: 90%; margin: 3px; width:1200px"
|valign=top|
|valign=top|
|+
|+
! style="background: #4479BA; width: 500px;" | {{fontcolor|#FFF|Primary}}
! style="background: #4479BA; width: 700px;" | {{fontcolor|#FFF|Primary}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Median survival (months)}}
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Median survival (months)}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|95% C.I.}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|95% C.I.}}

Revision as of 23:33, 16 November 2015

Intracerebral metastases Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Intracerebral Metastases from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Intracerebral metastases natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Intracerebral metastases natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Intracerebral metastases natural history, complications and prognosis

CDC on Intracerebral metastases natural history, complications and prognosis

Intracerebral metastases natural history, complications and prognosis in the news

Blogs on Intracerebral metastases natural history, complications and prognosis

Directions to Hospitals Treating Intracerebral metastases

Risk calculators and risk factors for Intracerebral metastases natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

If left untreated, patients with intracerebral metastases may progress to develop seizures, altered mental status, hemiplegia, focal neurological deficits, hemorrhage, brain herniation, coma, and death.[1][2] Common complications of intracerebral metastases include brain herniation, hemorrhage, coma, and stroke. Depending on the type of the primary cancer, the age of the patient, absence or presence of extracranial metastases, and the number of metastatic sites in the brain at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor. The median survival time of all patients with intracerebral metastases is 2.3 months.[3][4]

Natural History

If left untreated, patients with intracerebral metastases may progress to develop seizures, altered mental status, hemiplegia, focal neurological deficits, hemorrhage, brain herniation, coma, and death.[1][2]

Complications

Common complications of intracerebral metastases include:[2]

Prognosis

  • Depending on the type of primary cancer, the age of the patient, absence or presence of extracranial metastases, and the number of metastatic sites in the brain at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor.[3][4]
  • The median survival time of all patients with intracerebral metastases is 2.3 months.
  • The primary tumor-specific prognosis of intracerebral metastases are tabulated below:[4]
Primary Median survival (months) 95% C.I.
Non-small cell lung cancer 7 6.53 - 7.50
Small cell lung cancer 4.9 4.30 - 6.20
Melanoma 6.74 5.90 - 7.57
Renal cell carcinoma 9.63 7.66 - 10.91
Breast cancer 11.93 9.69 - 12.85
Gastrointestinal cancer 5.36 4.30 - 6.30
Unknown 6.37 5.22 - 7.49
  • However, in some patients such as those with no extracranial metastases, the prognosis is much better with the median survival rate of upto 13.5 months.[3]
  • Favorable prognostic factors (median survival time of 13.5 months) for intracerebral metastases include:[3][5]
  • No extracranial metastases
  • Age less than 65 years
  • Single site of metastasis in the brain
  • Responsive to steroid treatment
  • No impairment of neurocognitive function
  • Supratentorial location
  • Female gender

References

  1. 1.0 1.1 Clinical presentation of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 9, 2015
  2. 2.0 2.1 2.2 Andrew B. Lassman & Lisa M. DeAngelis (2003). "Brain metastases". Neurologic clinics. 21 (1): 1–23. PMID 12690643. Unknown parameter |month= ignored (help)
  3. 3.0 3.1 3.2 3.3 Prognosis of brain metastasis. Wikipedia 2015. https://en.wikipedia.org/wiki/Brain_metastasis. Accessed on November 9, 2015
  4. 4.0 4.1 4.2 Khuntia, Deepak (2015). "Contemporary Review of the Management of Brain Metastasis with Radiation". Advances in Neuroscience. 2015: 1–13. doi:10.1155/2015/372856. ISSN 2356-6787.
  5. Fabi, Alessandra; Felici, Alessandra; Metro, Giulio; Mirri, Alessandra; Bria, Emilio; Telera, Stefano; Moscetti, Luca; Russillo, Michelangelo; Lanzetta, Gaetano; Mansueto, Giovanni; Pace, Andrea; Maschio, Marta; Vidiri, Antonello; Sperduti, Isabella; Cognetti, Francesco; Carapella, Carmine M (2011). "Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center". Journal of Experimental & Clinical Cancer Research. 30 (1): 10. doi:10.1186/1756-9966-30-10. ISSN 1756-9966.


Template:WikiDoc Sources