Interstitial nephritis laboratory findings: Difference between revisions
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{{Interstitial nephritis}} | {{Interstitial nephritis}} | ||
{{CMG}} {{AE}}{{M.B}} | {{CMG}} {{AE}}{{M.B}} | ||
== Overview == | |||
An elevated plasma creatinine, Eosinophilia and eosinophiluria, is diagnostic of [disease name]. | |||
# Increased plasma creatinine | |||
# Eosinophilia and eosinophiluria | |||
# A characteristic urine sediment | |||
# A variable degree of proteinuria | |||
# Evidence of tubulointerstitial damage | |||
# High fractional sodium excretion | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
Revision as of 06:41, 3 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
An elevated plasma creatinine, Eosinophilia and eosinophiluria, is diagnostic of [disease name].
- Increased plasma creatinine
- Eosinophilia and eosinophiluria
- A characteristic urine sediment
- A variable degree of proteinuria
- Evidence of tubulointerstitial damage
- High fractional sodium excretion
Laboratory Findings
Blood
About 23% of patients have eosinophilia. Eosinophilia, when present, can be helpful in the evaluation of tubulointerstitial nephritis. However, this finding is neither specific nor sensitive enough to establish the diagnosis. Although the true incidence of eosinophilia in acute tubulointerstitial nephritis is unknown, it is estimated to be present in approximately half of patients. Typically, eosinophilia is absent in acute tubulointerstitial nephritis that is induced by nonsteroidal anti-inflammatory drugs (NSAIDs).
Urine
Urinary findings include:
- Eosinophiluria: sensitivity is 67% and specificity is 83%.[1] The sensitivity is higher in patients with interstitial nephritis induced by methicillin or when the Hansel's stain is used.
- Isosthenuria [2]
References
- ↑ Schwarz A, Krause P, Kunzendorf U, Keller F, Distler A (2000). "The outcome of acute interstitial nephritis risk factors for the transition from acute to chronic interstitial nephritis". Clin Nephrol. 54 (3): 179–90. PMID 11020015.
- ↑ Lins R, Verpooten G, De Clerck D, De Broe M (1986). "Urinary indices in acute interstitial nephritis". Clin Nephrol. 26 (3): 131–3. PMID 3769228.