Interstitial nephritis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.

Overview

The majority of patients with interstitial nephritis are asymptomatic. However, nonspecific signs and symptoms may present depending upon underlying etiology and timing of presentation. Non specific symptoms include nausea, vomiting, malaise, and oliguria. Hematuria though not so common is also seen in some patients with interstitial nephritis. Other symptoms of interstitial nephritis include hypersensitivity reaction, such as rash, fever, and eosinophilia.

History

Patients with TIN may have a positive history of:

  • Drugs consumption especially antibiotic as well NSAIDS
  • Previous history of allergic drug reaction
  • Infections
  • Systemic disease including sarcoidosis, Sjogren's syndrome, systemic lupus erythematosus (SLE).

Symptoms

Common Symptoms

Common symptoms of interstitial nephritis include:

  • Nausea
  • Vomiting
  • Malaise
  • Oliguria
  • Fever
  • Rash

Less Common Symptoms

Less common symptoms of interstitial nephritis include:

  • Gross hematuria[1]
  • Proteinuria[2]

References

  1. Praga M, González E. Acute interstitial nephritis. Kidney Int 2010; 77:956
  2. Praga M, González E. Acute interstitial nephritis. Kidney Int 2010; 77:956

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