Interstitial nephritis history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
The majority of patients with TIN from any cause are asymptomatic; however, vague nonspicific signs and symptoms depend on whether the disease is acute or chronic may present.
Nevertheless, presence of symptoms or signs of a hypersensitivity reaction, such as rash, fever, and eosinophilia in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN.
In the chronic condition patients may experience symptoms such as nausea, vomiting, fatigue, and weight loss; as well features of electrolyte imbalances such as hyperkalemia, and metabolic acidosis may present.
History and Symptoms
- The majority of patients with TIN are asymptomatic.[1] however, when the nonspicific signs and symptoms do occur they are widely varied and can occur rapidly or gradually.[2][3][4][5][6] When caused by an allergic-type reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),[3] rash (15% of patients),[3] and eosinophilia (23% of patients).
- Some people experience dysuria, and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include hyperkalemia, metabolic acidosis, and kidney failure.
History
Patients with TIN may have a positive history of:
- Drugs consumption especially antibiotic as well NSAIDS
- Previous history of allergic drug reaction
- infections
- Systemic disease including sarcoidosis, Sjögren's syndrome, systemic lupus erythematosus (SLE),
Common Symptoms
Common symptoms of TIN include:
- The acute or subacute onset of nausea, vomiting, and malaise owing to acute renal dysfunction
- Oliguria
- .Fever
- Rash
Less Common Symptoms
Less common symptoms of TIN include:
References
- ↑ Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician 2003; 67:2527
- ↑ Rossert J (2001). "Drug-induced acute interstitial nephritis". Kidney Int. 60 (2): 804–17. doi:10.1046/j.1523-1755.2001.060002804.x. PMID 11473672.
- ↑ 3.0 3.1 3.2 .
- ↑ Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J (1983). "Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy". Q J Med. 52 (206): 194–211. PMID 6604293.
- ↑ Handa S (1986). "Drug-induced acute interstitial nephritis: report of 10 cases". CMAJ. 135 (11): 1278–81. PMID 3779558.
- ↑ Buysen J, Houthoff H, Krediet R, Arisz L (1990). "Acute interstitial nephritis: a clinical and morphological study in 27 patients". Nephrol Dial Transplant. 5 (2): 94–9. PMID 2113219.
- ↑ Praga M, González E. Acute interstitial nephritis. Kidney Int 2010; 77:956
- ↑ Praga M, González E. Acute interstitial nephritis. Kidney Int 2010; 77:956