Intensity of statin therapy in primary and secondary prevention: Difference between revisions
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==Overview== | ==Overview== | ||
The intensity of statin therapy is defined on the basis of the average expected | The intensity of statin therapy is defined on the basis of the average expected LDL response to a specific statin and dose. High-intensity statin daily therapy lowers LDL by approximately ≥50%, moderate-intensity statin lowers LDL by approximately 30% to <50%, and lower-intensity statin lowers LDL by <30%.<ref name="circ.ahajournals.org">{{Cite web | last = | first = | title = 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults | url =http://circ.ahajournals.org/content/early/2013/11/11/01.cir.0000437738.63853.7a.full.pdf+html | publisher = | date = | accessdate = 13 November 2013 }}</ref> | ||
==High-, Moderate-, and Low-Intensity Statin Therapy== | |||
==High- Moderate- and Low-Intensity Statin Therapy== | |||
{| {{table}} | {| {{table}} | ||
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| align="center" style="background:#f0f0f0;"|'''Moderate-Intensity Statin Therapy''' | | align="center" style="background:#f0f0f0;"|'''Moderate-Intensity Statin Therapy''' | ||
| align="center" style="background:#f0f0f0;"|'''Low-Intensity Statin Therapy''' | | align="center" style="background:#f0f0f0;"|'''Low-Intensity Statin Therapy''' | ||
|- | |- | ||
| valign="top" | '''Atorvastatin (40†)–80 mg''' <BR> '''Rosuvastatin 20 (40) mg''' || valign="top" | '''Atorvastatin 10 (20) mg''' <BR> '''Rosuvastatin (5) 10 mg''' <BR> '''Simvastatin 20–40 mg‡''' <BR> '''Pravastatin 40 (80) mg''' <BR> '''Lovastatin 40 mg''' <BR> Fluvastatin XL 80 mg <BR> '''Fluvastatin 40 mg bid''' <BR> Pitavastatin 2–4 mg || valign="top" |Simvastatin 10 mg <BR> '''Pravastatin 10–20 mg''' <BR> '''Lovastatin 20 mg''' <BR> Fluvastatin 20–40 mg <BR> Pitavastatin 1 mg | | valign="top" | '''Atorvastatin (40†)–80 mg''' <BR> '''Rosuvastatin 20 (40) mg''' || valign="top" | '''Atorvastatin 10 (20) mg''' <BR> '''Rosuvastatin (5) 10 mg''' <BR> '''Simvastatin 20–40 mg‡''' <BR> '''Pravastatin 40 (80) mg''' <BR> '''Lovastatin 40 mg''' <BR> Fluvastatin XL 80 mg <BR> '''Fluvastatin 40 mg bid''' <BR> Pitavastatin 2–4 mg || valign="top" |Simvastatin 10 mg <BR> '''Pravastatin 10–20 mg''' <BR> '''Lovastatin 20 mg''' <BR> Fluvastatin 20–40 mg <BR> Pitavastatin 1 mg | ||
Revision as of 19:04, 13 November 2013
Template:Hypercholesterolemia Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kashish Goel, M.D.
Overview
The intensity of statin therapy is defined on the basis of the average expected LDL response to a specific statin and dose. High-intensity statin daily therapy lowers LDL by approximately ≥50%, moderate-intensity statin lowers LDL by approximately 30% to <50%, and lower-intensity statin lowers LDL by <30%.[1]
High-, Moderate-, and Low-Intensity Statin Therapy
| High-Intensity Statin Therapy | Moderate-Intensity Statin Therapy | Low-Intensity Statin Therapy |
| Atorvastatin (40†)–80 mg Rosuvastatin 20 (40) mg |
Atorvastatin 10 (20) mg Rosuvastatin (5) 10 mg Simvastatin 20–40 mg‡ Pravastatin 40 (80) mg Lovastatin 40 mg Fluvastatin XL 80 mg Fluvastatin 40 mg bid Pitavastatin 2–4 mg |
Simvastatin 10 mg Pravastatin 10–20 mg Lovastatin 20 mg Fluvastatin 20–40 mg Pitavastatin 1 mg |
References
- ↑ "2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults". Retrieved 13 November 2013.