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==Differential Diagnosis==
==Differential Diagnosis==
Insulinoma must be differentiated from autoimmune [[hypoglycemia]], hypoglycemia due to [[sulfonylurea]] or [[insulin]] abuse, factitious hypoglycemia, noninsulinoma pancreatogenic hypoglycemia syndrome (NIPHS), familial persistent hyperinsulinemia, and [[nesidioblastosis]].<ref name="Abboud2008">{{cite journal|last1=Abboud|first1=Bassam|title=Occult sporadic insulinoma: Localization and surgical strategy|journal=World Journal of Gastroenterology|volume=14|issue=5|year=2008|pages=657|issn=1007-9327|doi=10.3748/wjg.14.657}}</ref>
Insulinoma must be differentiated from other diseases that cause features of [[hypoglycemia]] like [[altered mental status]]/[[confusion]], profuse [[sweating]] and visual disturbances ([[Blurred vision|blurring]]/[[diplopia]]).  These are classified on the basis of laboratory findings into exogenous [[insulin]], [[oral hypoglycemic agent]]<nowiki/>s (e.g. [[sulphonylurea]]<nowiki/>s), [[nesidioblastosis]], [[insulin autoimmune hypoglycemia]].


==Epidemiology and Demographics==
==Epidemiology and Demographics==

Revision as of 14:51, 15 September 2017

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

An insulinoma is a tumour of the pancreas derived from the beta cells which while retaining the ability to synthesize and secrete insulin is autonomous of the normal feedback mechanisms. Patients present with symptomatic hypoglycemia which is ameliorated by feeding. The diagnosis of an insulinoma is usually made biochemically with low blood sugar, elevated insulin, pro-insulin and C-peptide levels and confirmed by medical imaging or angiography. The definitive treatment is surgery. Pancreatic islet cells was first described by Paul Langerhans in 1869, while he was still a medical student. Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas. In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor. In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor. On microscopic histopathological analysis, solid or gyriform patterns, usually without glands are characteristic findings of insulinoma. Insulinoma may occur as part of other genetic syndromes such as multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome. Insulinoma must be differentiated from autoimmune hypoglycemia, hypoglycemia due to sulfonylurea or insulin abuse, factitious hypoglycemia, noninsulinoma pancreatogenic hypoglycemia syndrome (NIPHS), familial persistent hyperinsulinemia, and nesidioblastosis.[1] The incidence of insulinoma is approximately 0.1 to 0.4 per 100,000 individuals worldwide. There is no racial predilection to the insulinoma. Females are more commonly affected with insulinoma than males.[2] The male to female ratio is approximately 2 to 3. The median age at diagnosis is 45.5 years.[2] Common risk factors in the development of insulinoma include family history of multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome, rural population, female gender, and age (40 years or older). According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for insulinoma.[3] If left untreated, patients with insulinoma may progress to develop autonomic symptoms, neuroglycopenenic symptoms, and symptoms of catecholaminergic response. According to The American Joint Committee on Cancer (AJCC), there are four stages of insulinoma based on the TNM staging sysytem. Symptoms of insulinoma include diaphoresis, palpitations, confusions, seizures, sweating, tachycardia, and anxiety. A positive family history of multiple endocrine neoplasia type 1 or von Hippel-Lindau syndrome may be present. Common physical examination findings of insulinoma include tachycardia, jaundice, diplopia, tremors, and altered mental status. Laboratory findings consistent with the diagnosis of insulinoma include 72h suppression test and Whipple's triad. Findings on abdominal CT scan suggestive of insulinoma include calcification and hyper attenuation on arterial phase.[4] Findings on abdominal MRI suggestive of insulinoma include signal enhancement on T1 C+ (Gd).[5] Abdominal ultrasound scan may be helpful in the diagnosis of insulinoma. Findings on ultrasound scan suggestive of insulinoma are homogeneously hypoechoic, rounded in shape, and with distinct margins.[6] Other imaging studies for insulinoma include indium-111 pentetreotide scan. Other diagnostic studies for insulinoma include intra-arterial calcium stimulation test with hepatic venous sampling. The predominant therapy for insulinoma is surgical resection. Supportive therapy for insulinoma includes octerotide, endoscopic ultrasound guided alcohol ablation, radiofrequency ablation, embolization, diazoxide and chemotherapy. Surgery is the mainstay of treatment for insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.[6][7] There is no established method for prevention of insulinoma.

Historical Perspective

In 1869, pancreatic islet cells were discovered by Paul Langerhans and the first adenoma of islets was discovered by Nicholls in 1902. Insulin was first discovered by Banting and Best in 1922. Association between hyperinsulinism and functional islet tumor was described in 1926 by Wilder. In 1927 the insulinoma was first described in Mayo clinic which was dissected in 1929 in Toronto.[8]In 1929, the first surgical cure was performed by Roscoe Graham.[9]In 1935, Whipple suggested a diagnostic criterion for the diagnosis of Insulinoma called as Whipple's triad.[9]

Pathophysiology

  • Insulinoma arises from β islet cells, which are endocrine cells that are normally involved in the production of insulin. It is thought that insulinoma is mediated by mTOR/P70S6K signaling pathway. Inhibitors of mTOR (rapamycin) or dual PI3K/mTOR (NVP-BEZ2235) thus have become new drugs for treating insulinoma. YY1 gene is mutated by T372R mutation that causes a defect in mitochondrial function for glucose stimulated insulin action which is thought to be involved in mTOR pathway.The progression to hypoglycemia is actually because of decreased glucose synthesis rather than increased use due to the direct effect of insulin on the liver. Insulinoma is transmitted in an autosomal dominant pattern when it is associated with MEN 1 syndrome.They are usually small (90%), sporadic (90%), solitary (90%) and benign (90%) tumors.On gross pathology insulinomas have a gray to red-brown appearance, encapsulated.On microscopic histopathological analysis, patterns like trabecular, gyriform, lobular and solid structures, particularly with amyloid in the fibrovascular stroma, are characteristic findings of insulinoma. It is also evaluated for the mitotic index (mitosis per 10 high power field) and immunohistochemistry staining by Chromogranin A, synaptophysin, and Ki-67 index.The structure of tumor cells observed under electron microscopy as Group A characterized by abundant well-granulated typical B cells with trabecular arrangement and Group B as scarce well -granulated typical B cells and a medullary arrangement

Causes

There are no established causes for insulinoma.

Differential Diagnosis

Insulinoma must be differentiated from other diseases that cause features of hypoglycemia like altered mental status/confusion, profuse sweating and visual disturbances (blurring/diplopia). These are classified on the basis of laboratory findings into exogenous insulin, oral hypoglycemic agents (e.g. sulphonylureas), nesidioblastosis, insulin autoimmune hypoglycemia.

Epidemiology and Demographics

The incidence of insulinoma is approximately 0.1 to 0.4 per 100,000 individuals worldwide. There is no racial predilection to the insulinoma. Females are more commonly affected with insulinoma than males.[2] The male to female ratio is approximately 2 to 3. The median age at diagnosis is 45.5 years.[2]

Risk Factors

Common risk factors in the development of insulinoma include family history of multiple endocrine neoplasia type 1 and von Hippel-Lindau syndrome, rural population, female gender, and age (40 years or older).

Screening

According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for insulinoma.[10]

Natural History, Complications and Prognosis

If left untreated, patients with insulinoma may progress to develop autonomic symptoms, neuroglycopenenic symptoms, and symptoms of catecholaminergic response.

Staging

According to The American Joint Committee on Cancer (AJCC), there are four stages of insulinoma based on the TNM staging sysytem.

History and Symptoms

Symptoms of insulinoma include diaphoresis, palpitations, confusions, seizures, sweating, tachycardia, and anxiety. A positive family history of multiple endocrine neoplasia type 1 or von Hippel-Lindau syndrome may be present.

Physical Examination

Common physical examination findings of insulinoma include tachycardia, jaundice, diplopia, tremors, and altered mental status.

Laboratory Findings

Laboratory findings consistent with the diagnosis of insulinoma include 72h suppression test and Whipple's triad.

CT

Findings on abdominal CT scan suggestive of insulinoma include calcification and hyper attenuation on arterial phase.[4]

MRI

Findings on abdominal MRI suggestive of insulinoma include signal enhancement on T1 C+ (Gd).[5]

Ultrasonography

Abdominal ultrasound scan may be helpful in the diagnosis of insulinoma. Findings on ultrasound scan suggestive of insulinoma are homogeneously hypoechoic, rounded in shape, and with distinct margins.[6]

Other Imaging Findings

Other imaging studies for insulinoma include indium-111 pentetreotide scan.

Other Diagnostic Studies

Other diagnostic studies for insulinoma include intra-arterial calcium stimulation test with hepatic venous sampling.

Medical Therapy

The predominant therapy for insulinoma is surgical resection. Supportive therapy for insulinoma includes octerotide, endoscopic ultrasound guided alcohol ablation, radiofrequency ablation, embolization, diazoxide and chemotherapy.

Surgery

Surgery is the mainstay of treatment for insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.[6][7]

Primary Prevention

There is no established method for prevention of insulinoma.

Secondary Prevention

There are no secondary preventive measures available for insulinoma.

References

  1. Abboud, Bassam (2008). "Occult sporadic insulinoma: Localization and surgical strategy". World Journal of Gastroenterology. 14 (5): 657. doi:10.3748/wjg.14.657. ISSN 1007-9327.
  2. 2.0 2.1 2.2 2.3 Vázquez Quintana E (2004). "The surgical management of insulinoma". Bol Asoc Med P R. 96 (1): 33–8. PMID 15575328.
  3. USPTF.http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=insulinoma
  4. 4.0 4.1 Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/insulinoma
  5. 5.0 5.1 Insulinoma. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. http://radiopaedia.org/articles/insulinoma accessed on 10 October, 2015.
  6. 6.0 6.1 6.2 6.3 Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y; et al. (2013). "Diagnosis and management of insulinoma". World J Gastroenterol. 19 (6): 829–37. doi:10.3748/wjg.v19.i6.829. PMC 3574879. PMID 23430217.
  7. 7.0 7.1 Inulinoma. national library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000387.htm
  8. 9.0 9.1
  9. USPTF.http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=insulinoma