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==Famous Cases==
==Famous Cases==
*The following are a few famous cases of [[disease name]]:
*The following are a few famous cases of [[disease name]]:
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 19:58, 9 August 2017

Insulinoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Pancreatic islet cells were first described by Paul Langerhans in 1869, while he was still a medical student. Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas. In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor. In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.

Historical Perspective

  • Pancreatic islet cells were first described by Paul Langerhans in 1869, while he was still a medical student.
  • Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas.
  • In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor.
  • In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.[1]
  • Hypoglycemia was first recognized in the 19th century. In the 1920s, after the discovery of insulin and its use in the treatment of diabetics, hyperinsulinism was suspected to be a cause of hypoglycemia in non-diabetics.[2]
  • A pioneering description of hyperinsulinism as a cause of hypoglycemia was published by Seale Harris in 1924.[2]
  • The first report of a surgical cure of hypoglycemia by removing an islet cell tumour was in 1929.

Overview

Historical Perspective

Discovery

  • [Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].
  • The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
  • In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
  • In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

Outbreaks

  • There have been several outbreaks of [disease name], which are summarized below:

Landmark Events in the Development of Treatment Strategies

  • In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Impact on Cultural History

Famous Cases

References

  1. Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
  2. 2.0 2.1 Insulinoma. Wikipedia. https://en.wikipedia.org/wiki/Insulinoma. Accessed on October 5,2015

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