Insulator (genetics)

Revision as of 18:37, 4 September 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

An insulator is a genetic boundary element that plays two distinct roles in gene expression, either as an enhancer-blocking element, or more rarely as a barrier against condensed chromatin proteins spreading onto active chromatin. The need for them arises where two adjacent genes on a chromosome have very different transcription patterns, and it is critical that the inducing or repressing mechanisms of one do not interfere with the neighbouring gene.[1]

References

  1. Burgess-Beusse, B; et al. (2002). "The insulation of genes from external enhancers and silencing chromatin". Proc. Natl Acad. Sci. USA. 9 (Suppl 4): 16433–16437. doi:10.1073/pnas.162342499. Unknown parameter |month= ignored (help)

de:Isolator (Genetik)